CAS: 15690-57-0; Trans-Clomiphene

上下游产品

(Z)-4-(2-Chloro-1,2-Diphenylethenyl) Methoxybenzene 72474-42-1
Cis-1-Chloro-2-(4-Hydroxyphenyl)-1,2-Diphenylethylene 72474-40-9
Deschloro Clomiphene

2-二乙氨基氯乙烷盐酸盐置于tris-(Dibenzylideneacetone)Dipalladium(0),Copper(L) Iodide,三苯胂,Sodium Ethanolate,Lithium Chloride,Copper Dichloride体系中,用 乙醇 用作溶剂,化学反应 130.0H,反应生成恩氯米芬
参考文献:克罗米芬和他莫昔芬的立体有择合成二苯乙炔的锡铜
标题:克罗米芬和他莫昔芬的立体有择合成二苯乙炔的锡铜
摘要:摘要 二苯乙炔的立体有择反式-锡铜反应得到 1,2-二金属芪,通过钯催化与芳基碘偶联可将其加工成克罗米芬或他莫昔芬.
Doi:10.1080/00397919508011484

专利信息

专利号:US-11873305-B2
优先权日:2020-06-30
标题 :Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds
发明人：ZHANG HAIMING; XU JIE; WUITSCHIK GEORG; ANGELAUD REMY; HEROLD SEBASTIAN; STUTZ ALFRED; BRUETSCH TOBIAS; BURKHARD JOHANNES
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are processes for the preparation of indolyl intermediates using Wenker Synthesis for the total synthesis of SERD compounds useful in the treatment of cancer.

专利号:US-5817751-A
优先权日:1994-06-23
标 题 :Method for synthesis of diketopiperazine and diketomorpholine derivatives
发明人：SZARDENINGS ANNA KATRIN; CAMPBELL DAVID
权利人:AFFYMAX TECH NV
摘要:The present invention relates to the areas of organic and medicinal chemistry. More specifically, the present invention is concerned with combinatorial and solid phase methods for the synthesis of diverse diketopiperazine derivatives, and the use of such methods to create libraries of diverse diketopiperazine derivatives. The present invention has application in the areas of chemical synthesis, the screening for new diketopiperazine derivatives having beneficial medical properties and the use of such screening to provide compositions and methods including diketopiperazine derivatives for treating disease.

专利号:US-4895939-A
优先权日:1986-02-24
标题:High percentage β-yield synthesis of carbapenem intermediates
发明人：MARTEL ALAIN; DARIS JEAN-PAUL; CORBEIL JACQUES
权利人:BRISTOL MYERS CO
摘要:Disclosed herein is a novel high beta -yield producing novel intermediates of the formula where R4 is useful in the synthesis of 1- beta -alkyl carbapenems.

专利号:US-9902699-B2
优先权日:2012-10-24
标题 :Synthesis of tetrahydroisoquinolines from 2-methyl-1-phenyl substituted indenes
发明人：ROSOCHA GREGORY; BATEY ROBERT
权利人:ROSOCHA GREGORY; Gregory Rosocha
摘要:A procedure for the synthesis of tetrahydroisoquinolines from 2-methyl-1-phenyl substituted indene is described. The process involves the use of osmium tetroxide to cleave the indene double bond forming the keto aldehyde product, which is then combined with a substituted amine forming the substituted isoquinoline. Isoquinolines can be useful as industrial products in the chemical, agrochemical, oil and gas industry, as well as useful as medicaments in the pharmaceutical industry.

专利号:US-5633373-A
优先权日:1989-07-07
标 题 :Enantioselective synthesis of antifolates
发明人：BARNETT CHARLES J; WILSON THOMAS M
权利人:LILLY CO ELI
摘要:A process and intermediates for the enantioselective synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid are disclosed.

专利号:US-5446203-A
优先权日:1992-08-25
标题:Synthesis of haloenones and aryl or alkyl substituted enones or alkenes
发明人：MCNELIS EDWARD
权利人:UNIV NEW YORK
摘要:Alternative methods for synthesizing haloenones and haloakenes and their use as starting materials for synthesis of substituted or unsubstituted alkyl and aryl substituted enones and alkenes, including tamoxifen and tamoxifen analogs, using such haloenones and haloalkenes.