CAS: 1859053-21-6; 8-Fluoro-5-(4-((Methylamino)Methyl)Phenyl)-2,3,4,6-Tetrahydro-1H-Azepino[5,4,3-Cd]Indol-1-One ((1S,4R)-7,7-Dimethyl-2-Oxobicyclo[2.2.1]Heptan-1-yl)Methanesulfonate

Methyl N-[[4-(6-Fluoro-3-Oxido-10-Aza-3-Azoniatricyclo[6.4.1.04,13]Trideca-1(13),5,7-Trien-10-yl)Phenyl]Methyl]-N-Methylcarbamate 以88的收率获得瑞卡帕布樟脑磺酸盐
参考文献: Method Of Preparing Poly(Adp-Ribose) Polymerases Inhibitors[fr] Procede De Preparation D'Inhibiteurs De Poly(Adp-Ribose) Polymerases
标题: Method Of Preparing Poly(Adp-Ribose) Polymerases Inhibitors[fr] Procede De Preparation D'Inhibiteurs De Poly(Adp-Ribose) Polymerases
摘要:该发明涉及一种新的,汇聚的方法制备聚(Adp-核糖)聚合酶的小分子抑制剂,例如8-氟-2-{4-[(甲基氨基)甲基]苯基}-1,3,4,5-四氢-6H-氮杂[5,4,3-Cd]吲哚-6-酮,通过关键的sonogashira偶联反应和cul促进的吲哚形成.

专利信息

专利号:US-2022118094-A1
优先权日:2019-02-21
标题:Synthesis of biomimetic cell wall structure
发明人：WANG YONG; SHI PENG
权利人:PENN STATE RES FOUND
摘要:The present invention relates generally to methods of generating a biomimetic cell wall (BCW) on a target surface, compositions comprising the BCW, and methods of use of the compositions, including biomedical applications of the BCW coated compositions.

专利号:US-2023391824-A1
优先权日:2021-02-08
标题:Rationale, design, synthesis and validation of a small molecule anticancer agent
发明人：JAIN MOHIT; NARENDRAN ARUMUGAVADIVEL
权利人:NARENDRAN ARUMUGAVADIVEL
摘要:LIN28 is an RNA binding protein that binds and inhibits the expression and maturation of Iet7 microRNA that carries key tumor suppressor functions. Thus, LIN28 is a feasible and effective molecular target for directed inhibition with the potential to provide therapeutic benefit to a diverse group of aggressive malignancies. The present disclosure relates generally to the Rationale, Design, Synthesis and Validation of a Novel Small Molecule Inhibitor of LIN28, coined Compound of formula (I), for the Treatment of Adult and Pediatric Malignancies. In addition, indications of this agent to block cancer metastasis, inhibit cancer stem cells to prevent relapse, and to synergize with immunotherapy, chemotherapy and radiotherapy are also been described.

专利号:WO-2025023769-A1
优先权日:2023-07-25
标 题:Novel synthesis method of 18f-rucaparib
发明人：CHEON CHEOL-HONG; PARK JINJAE; SEO JUAN
权利人:UNIV KOREA RES & BUS FOUND
摘要:The present invention relates to a method for efficiently preparing rucaparib for a PET image. More specifically, the present invention relates to an improved preparation method for synthesizing [18F]-rucaparib in excellent yield by means of a pathway for synthesizing a pinacol boronate derivative, which is a key intermediate, by using, as a starting material, a 2-iodoaniline derivative prepared by a novel synthesis method.

专利号:WO-2025137620-A1
优先权日:2023-12-21
标题:Methods for high quality and high accuracy methylation sequencing
发明人：KENNEDY ANDREW
权利人:GUARDANT HEALTH INC
摘要:Provided herein are methods and compositions for calibrating one or more base calling metrics in a sequencing by synthesis reaction, and for calling at least a portion of nucleobases in a converted region of a DNA molecule using the one or more calibrated base calling metrics. Provided herein are also methods for determining the likelihood that a subject has a disease or condition, such as cancer.

专利号:EP-4288444-A1
优先权日:2021-02-08
标题:Rationale, design, synthesis and validation of a small molecule anticancer agent

专利号:WO-2022165606-A1
优先权日:2021-02-08
标 题:Rationale, design, synthesis and validation of a small molecule anticancer agent