月桂酸置于氯化亚砜体系中,用 乙醚 用作溶剂,化学反应生成N-甲基十二胺
参考文献:Dodecanoic Acid Derivatives: Synthesis,Antimicrobial Evaluation And Development Of One-Target And Multi-Target Qsar Models
标题:Dodecanoic Acid Derivatives: Synthesis,Antimicrobial Evaluation And Development Of One-Target And Multi-Target Qsar Models
摘要:In This Study A Series Of Dodecanoic Acid Derivatives (1-30) Were Synthesized And Evaluated For In Vitro Antimicrobial Activity Against The Panel Of Gram Positive,Gram Negative Bacterial And Fungal Strains. 4-Nitro Phenyl Dodecanoate (4) And Quinolin-8-Yl Dodecanoate (5) Emerged As Most Effective Antibacterial Agents,And 1-(4-Benzylpiperazin-1-yl) Dodecan-1-One (15) Was Found To Be The Most Effective Antifungal Agent Amongst The Synthesized Dodecanoic Acid Derivatives. Quantitative Structure Activity Relationship (Qsar) Studies Performed By The Development Of One-Target And Multi-Target Models Indicated That Multi-Target Model Was Effective In Describing The Antimicrobial Activity Of Dodecanoic Acid Derivatives As Well Demonstrated The Importance Of Topological Parameter,Zero-Order Molecular Connectivity Index ((0)Chi).
Doi:10.1007/s00044-010-9383-5