专利号:US-5817613-A 优先权日:1995-12-13 标题:Amino nitrile intermediate for the preparation of 2-hydroxyethyl iminodiacetic acid 发明人:ATHEY PHILLIP S; WILSON DAVID A; CRUMP DRUCE K 权利人:DOW CHEMICAL CO 摘要:A novel intermediate useful in the synthesis of 2-hydroxyethyl iminodiacetic acid is disclosed. The intermediate can be formed by contacting 2-hydroxyethyl amine with glycolonitrile to form an aminonitrile which can be hydrolyzed and contacted with additional glycolonitrile to form the nitrile intermediate which can be converted to 2-hydroxylethyl iminodiacetic acid via hydrolysis.
专利号:US-5481018-A 优先权日:1995-03-31 标题:Amino nitrile intermediate for the preparation of alanine diacetic acid 发明人:ATHEY PHILLIP S; WILSON DAVID A; CRUMP DRUCE K 权利人:DOW CHEMICAL CO 摘要:A novel intermediate useful in the synthesis of alpha-alanine diacetic acid or its salts is disclosed. The intermediate can be formed by contacting alanine with glycolonitrile under alkaline conditions or glycine with lactonitrile to form an aminonitrile which can be hydrolyzed and then contacted with additional glycolonitrile to form the nitrile intermediate which can be converted to alpha-alanine diacetic acid via hydrolysis.
专利号:US-5488130-A 优先权日:1995-03-31 标 题:Amino nitrile intermediate for the preparation of 2-hydroxypropyl iminodiacetic acid 发明人:ATHEY PHILLIP S; CRUMP DRUCE K; WILSON DAVID A 权利人:DOW CHEMICAL CO 摘要:A novel intermediate useful in the synthesis of 2-hydroxypropyl iminodiacetic acid is disclosed. The intermediate can be formed by contacting 2-hydroxypropyl amine with glycolonitrile to form an aminonitrile which can be hydrolyzed and contacted with additional glycolonitrile to form the nitrile intermediate which can be converted to 2-hydroxylpropyl iminodiacetic acid via hydrolysis.
专利号:US-12007376-B2 优先权日:2014-02-26 标题 :Method for determining a concentration of a synthesis component in a radiopharmaceutical sample 发明人:LEBEDEV ARTEM Y; ELIZAROV ARKADIJ M 权利人:TRACE ABILITY INC 摘要:A method for determining a concentration of a synthesis component in a radiopharmaceutical sample comprises providing an indicator, a metal or a metal complex, contacting the radiopharmaceutical sample with the indicator, metal or metal complex for a period of time sufficient to obtain an interaction, measuring an optical characteristic of the interacted components, and determining a concentration of the synthesis component in the radiopharmaceutical sample based on the measured optical characteristic.
专利号:JP-H11502834-A 优先权日:1995-03-31 标 题:Amino nitrile intermediates for the synthesis of alanine diacetate
专利号:US-10309947-B2 优先权日:2013-02-27 标题:System and method for radiosynthesis, quality control and dose dispensing 发明人:ELIZAROV ARKADIJ; LEBEDEV ARTEM 权利人:TRACE ABILITY INC 摘要:A system and method for performing radiochemical synthesis, analysis and/or dispensing of radiopharmaceuticals using specially designed disposable components: palettes and caddies, the palette being an assembly of containers not connected with each other for direct material transfer; the caddy being a disposable component used to transfer material between containers on the palettes and/or other locations.
1: Sundararajan NR, Whitney RM. Murexide for determination of free and protein- bound calcium in model systems. J Dairy Sci. 1975 Nov;58(11):1595-608. doi: 10.3168/jds.S0022-0302(75)84757-6. 24(3):855-8. doi: 10.1007/s10895-014-1363-6. Epub 2014 Feb 13. 560:30-38. doi: 10.1016/j.ab.2018.08.023. Epub 2018 Aug 29. 98:746-752. doi: 10.1016/j.msec.2018.12.055. Epub 2018 Dec 19. 59(1):86-93. doi: 10.1021/acs.inorgchem.8b03605. Epub 2019 Feb 19.
合成参考文献
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