CAS: 5467-74-3; (4-Bromophenyl)Boronic Acid

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CAS号460-00-4 对氟溴苯 | CAS号374564-35-9 4-溴苯基三氟硼酸钾 | CAS号92-86-4 4,4-二溴联苯 | CAS号4151-80-8 4,4'-联苯基二硼酸 | CAS号50670-58-1 4'-溴-[1,1'-二苯基]-4-甲醛 | CAS号398-21-0 4-溴-4′-氟联苯 | CAS号40292-15-7 4-溴-4'-硝基二苯甲酮 | CAS号352437-09-3 1-B°C-4-(4-溴苯基)哌嗪 | CAS号586-78-7 对溴硝基苯 | CAS号584-48-5 1-溴-2,4-二硝基苯

4-溴苯胺 以 水,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 0.53H,反应生成 4-溴苯硼酸
参考文献:轻松合成(杂)芳基硼酸
标题:轻松合成(杂)芳基硼酸
摘要:重氮盐和二硼酸之间空前的自发反应性已经被揭示出来,从而导致直接由(杂)芳基胺合成多功能的芳基硼酸.这种快速反应(总共35分钟)可耐受各种官能团,并且在非常温和的条件下进行.研发了反应机理的根本性质.
DOI:10.1002/chem.201402487

专利信息

专利号:US-8647848-B2
优先权日:2008-06-13
标题:Enzymatic synthesis of sphingolipids
发明人：HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS
权利人:HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS; EVONIK GOLDSCHMIDT GMBH
摘要:The invention relates to the enzymatic synthesis of sphingolipids and compositions that contain sphingolipids from lysosphingolipids and carbonic esters, and to cosmetic, dermatological or pharmaceutical formulations containing said sphingolipids or compositions.

专利号:US-6919382-B2
优先权日:2000-08-31
标 题 :Preparation and uses of conjugated solid supports for boronic acids
发明人：HALL DENNIS G
权利人:UNIV ALBERTA
摘要:The invention provides novel solid supports comprising dihydroxyalkyl aminoalkyl and dihydroxyalkylaminobenzyl groups, and methods for making and using them. The supports are particularly useful for immobilizing and derivatizing functionalized boronic acids for use in solid phase synthesis, such as those used in combinatorial chemistries. The compositions and methods of the invention are also useful as scavenger solid supports, e.g., in solution-phase parallel synthesis of small molecule libraries, and for use in resin-to-resin transfer reactions via phase transfer of solid supported boronic acids under both aqueous and anhydrous conditions. The methods of the invention provide convergent solid-phase synthesis of symmetrically or unsymmetrically functionalized compounds, such as biphenyl compounds. Also provided are synthesizer devices, e.g., semiautomated parallel synthesizers.

专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

专利号:US-9856275-B2
优先权日:2013-02-12
标 题:Synthesis and use of fluorinated compounds
发明人：MOLANDER GARY ALAN; ARGINTARU OANA ANDREEA
权利人:UNIV PENNSYLVANIA
摘要:The invention is directed to the preparation of fluorinated compounds and their use in organic synthesis. In particular, the invention is directed to methods of reacting compounds of structure with R f —CHâ•?N 2 or (CF 3 ) 2 Câ•?N 2 to form a perfluoroalkylate or -arylated compounds, and products derived from these reactions, where X, Y B , and R f are described herein.

专利号:US-2017266353-A1
优先权日:2014-05-13
标 题:Bioadhesive compounds and methods of synthesis and use
发明人：MURPHY JOHN L; RADANO CHRISTOPHER P; DALSIN JEFFREY L; KOEPSEL JUSTIN T
权利人:DSM IP ASSETS BV
摘要:Synthesis methods for creating polymeric compounds comprising phenyl derivatives (PD), or PDp i.e., polymers modified with PD, with desired surface active effects are described. The polymer backbone of PDp has structural or performance features that can be tailored to control physical properties of PDp, allowing it to be useful for different applications i.e., tissue adhesives or sealants, adhesion promoting coatings, and antifouling coatings.

专利号:US-11939325-B2
优先权日:2020-07-27
标 题 :Process for making biologically active compounds and intermediates thereof
发明人：MAKRIYANNIS ALEXANDROS; VEMURI KIRAN
权利人:MAKSCIENTIFIC LLC
摘要:A process of manufacturing biologically active compounds, their analogs, pharmaceutically acceptable salts, solvates, polymorphs, isotopic variants, and intermediates thereof. Notably, the compounds of the formula IA, 1B, 1C. 1D. 1E, 1F and IG for which novel processes have been disclosed, selectively act on the cannabinoid receptors, and with high affinity. The processes for the preparation of the compounds enable the syntheses of cannabinoid modulators on a large-scale that are eco-friendly and economically viable. Additionally, the processes disclosed enable the synthesis of cannabinoid modulators with high purity and in high yield for their use in making drug substance and drug products.