CAS: 552-82-9; N-Methyl-N-Phenylaniline

上下游产品

methanol diphenylamine hydr°Chloride diphenylformamide ethyl diphenylcarbamateN-nitrosodiphenylamine N-methyl-N-phenylaniline N-oxide (4-(methyl(phenyl)amino)phenyl)(phenyl)methanone 2-(N-Methyl-N-phenylamino)-benzoic acid

N,N-二苯基-1H-咪唑甲酰胺置于sodium Tetrahydroborate,碘体系中,用 四氢呋喃 作为反应溶剂,化学反应 6.0H,以67%的收率获得产物n-甲基二苯胺
参考文献:用 Nabh4/i2 系统还原 N-取代的羰基咪唑合成单甲胺的通用方法
标题:用 Nabh4/i2 系统还原 N-取代的羰基咪唑合成单甲胺的通用方法
摘要:描述了在回流温度下通过在 Thf中用 Nabh 4 /i 2还原n-取代的羰基咪唑来一锅合成单甲胺的经济且通用的方案.该方法不使用特殊的催化剂,可以从包括胺类(伯胺和仲胺),羧酸和异氰酸酯在内的多种原料中以中等至非常好的收率轻松获得各种单甲胺.此外,观测到有趣的还原选择性.对反应过程的探索表明,它通过甲酰胺中间体和甲酰胺中间体还原为单甲胺作为速率决定步骤经历了两步途径.这项工作有助于显着扩展n-取代的羰基咪唑.
DOI:10.3762/bjoc.18.104

专利信息

专利号:US-6258960-B1
优先权日:2000-03-17
标题:Catalytic asymmetric synthesis of chiral aziridines
发明人：ANTILLA JON; WULFF WILLIAM D
权利人:ARCH DEV CORP
摘要:The present invention relates to the synthesis of chiral cis-aziridines (IIIa and IIIb) by reacting an imine (I) with a diazo compound (II) in the presence of a chiral vaulted biary-Lewis Acid complex as shown below:

专利号:US-7368568-B2
优先权日:2001-08-03
标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for production and the use
发明人：WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
权利人:BAYER SCHERING PHARMA AG
摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroarnides for the synthesis of edothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.

专利号:WO-0056708-A1
优先权日:1999-03-19
标题 :Catalytic asymmetric synthesis of chiral aziridines
发明人：WULFF WILLIAM D; ANTILLA JON
权利人:ARCH DEV CORP
摘要:The present invention relates to the synthesis of chiral cis-aziridines (IIIa and IIIb) by reacting an imine (I) with a diazo compound (II) in the presence of a chiral vaulted biaryl-Lewis Acid complex as shown.

专利号:US-6933385-B2
优先权日:2001-08-03
标题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use
发明人：WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
权利人:SCHERING AG
摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.

专利号:US-9567307-B2
优先权日:2011-01-07
标题:Amination of aryl alcohol derivatives
发明人：GARG NEIL K; RAMGREN STEPHEN D; SILBERSTEIN AMANDA L; QUASDORF KYLE W
权利人:GARG NEIL K; RAMGREN STEPHEN D; SILBERSTEIN AMANDA L; QUASDORF KYLE W; UNIV CALIFORNIA
摘要:Embodiments of the invention provide methods and materials for chemical cross-coupling reactions that utilize aryl alcohol derivatives as cross-coupling partners. Embodiments of the invention include methods for the amination of aryl sulfamates and carbamates, which are attractive cross-coupling partners, particularly for use in multistep synthesis. Illustrative embodiments include versatile means to use simple derivatives of phenol as precursors to polysubstituted aryl amines, as exemplified by a concise synthesis of the antibacterial drug linezolid.

专利号:US-6228988-B1
优先权日:1995-02-24
标题:Synthesis of hydroxamic acid derivatives
发明人：FLOYD CHRISTOPHER DAVID; LEWIS CHRISTOPHER NORMAN
权利人:BRITISH BIOTECH PHARM
摘要:The present invention describes processes for preparing desired synthetic products that comprise a covalently bonded hydroxamic acid group -CONHOH by forming a mixture of a liquid reaction medium and a solid phase reaction product that carries a plurality of moieties of formula (A1) or (B1):where X is a residual, non-hydroxamate partial structure of the desired synthetic product, P1 is hydrogen or an amino-protecting group, P2 is hydrogen or a hydroxyl protecting group, and the bond designated (a) covalently links the moieties (A1) or (B1) to the residue of a solid substrate; by cleaving the bond designated (a) in the resultant mixture; and by separating the resultant liquid reaction phase from the resultant reaction solids to recover the desired synthetic product.