CAS: 609-09-6; Diethyl 2-Oxomalonate

相似化合物

133318-40-8 96-26-4 26776-70-5

上下游产品

CAS号3377-20-6 甲撑丙二酸二乙酯 | CAS号105-53-3 丙二酸二乙酯 | CAS号685-87-0 溴代丙二酸二乙酯 | CAS号4513-67-1 Propanedioic ac... | CAS号18856-68-3 二甲氨亚甲基丙二酸二乙酯 | CAS号631-23-2 2,2-二羟基丙二酸 1,3-二乙酯 | CAS号631-22-1 二溴丙二酸二乙酯 | CAS号5468-23-5 乙酰氧基丙二酸二乙酯 | CAS号109496-98-2 5-苯基靛红 | CAS号49679-45-0 3-氯喹喔啉-2-甲酸乙酯 | CAS号60578-70-3 6,7-二氯-3,4-二氢-3... | CAS号5588-87-4 苯并[e]靛红 | CAS号76-84-6 三苯基甲醇 | CAS号1471-86-9 Pyrido[2,3-b]py... | CAS号36818-07-2 3-氧代-3,4-二氢-2-喹... | CAS号2311-82-2 2-Quinoxalineca... | CAS号56-81-5 甘油 | CAS号105-53-3 丙二酸二乙酯

丙二酸二乙酯置于cu(2,9-Dimethyl-1,10-Phenanthroline)2Cl体系中,用 甲醇 作为反应溶剂,化学反应生成 酮基丙二酸二乙酯
参考文献:发散和协同光催化:乙烯基芳烃的氢化和氧代烷基化,通过 1,3-二羰基的正式 [4+1]-环化立体选择性合成环戊醇
标题:发散和协同光催化:乙烯基芳烃的氢化和氧代烷基化,通过 1,3-二羰基的正式 [4+1]-环化立体选择性合成环戊醇
摘要:描述了 1,3-二羰基的可控发散反应性,这使得乙烯基芳烃的有效加氢和氧代烷基化成为可能.两种反应途径都是通过极性反转c的形成启动的通过直接光催化 C-H 键转换在 1,3-二羰基的活性亚甲基中心反应生成中心自由基中间体.烯烃的氧代烷基化在有氧条件下通过 Cu(II)-光介导的回弹机制实现,而相应的加氢烷基化在氮气气氛下通过 4Czipn 和 Brønsted 碱的组合成为可能.这些不同方案的广度在药物和天然产物的后期修饰以及将产物转化为各种杂环化合物(如吡啶,吡咯或呋喃)中得到证明.此外,这两种催化模式可以协同组合,在正式的[4+1]-环化过程中立体选择性构建环戊醇衍生物.
DOI:10.1021/acscatal.2C04736

专利信息

专利号:US-2024124910-A1
优先权日:2021-02-02
标题:Ribosome-mediated polymerization of novel chemistries
发明人：JEWETT MICHAEL CHRISTOPHER; LEE JOONGOO; ANSLYN ERIC V; CORONADO JAIME; LIM JONGDOO
权利人:UNIV NORTHWESTERN; UNIV TEXAS
摘要:Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.

专利号:US-2022177406-A1
优先权日:2019-04-01
标 题 :Novel process for preparation of key intermediate of pinoxaden
发明人：CHANDRASEKHAR S; Punith B; SIVARAMI REDDY B
权利人:Bhagiradha Chemicals & Industries Ltd
摘要:A novel process for preparation of compounds of formula (I) used in the synthesis of Pinoxaden. The intermediate is a substituted phenyl malonic esters of formula (I), where R is C 1 -C 4 alkyl, straight or branched chain.

专利号:US-6809195-B1
优先权日:2000-08-16
标 题:Process for the preparation of oligonucleotides
发明人：SANGHVI YOGESH S; SONG QUANLAI
权利人:ISIS PHARMACEUTICALS INC
摘要:The present invention discloses methods for synthesizing oligomeric compounds. The methods include a modified phosphoramidite protocol wherein the oxidation and capping steps are combined into a single step. The methods result in increased efficiency and are especially amenable to the large scale synthesis of oligomeric compounds.

专利号:US-2018334427-A1
优先权日:2015-11-18
标 题 :Process for the Synthesis of Intermediates Useful for Preparing 1,3,4-Triazine Derivatives

专利号:US-2024239799-A1
优先权日:2021-04-02
标 题:(s)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'h,6'h-spiro[piperidine-4,5'-pyrrolo [1,2-b]pyrazol]-4'-amine derivatives and similar compounds as shp2 inhibitors for the treatment of e.g. cancer
发明人：DI FABIO ROMANO; MONTALBETTI CHRISTIAN; PETROCCHI ALESSIA; GRILLO ALESSANDRO; RANDAZZO PIETRO; ROSSETTI ILARIA; CIAMMAICHELLA ALINA
权利人:C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING; IRBM S P A
摘要:The present invention relates to compounds of formula (I). The compounds of the formula (I) are e.g. (S)-1-(5-((pyridin-3-yl)thio) pyrazin-2-yl)-41H,6′H-spiro[piperidine-4,5′-pyrrolo[1,2-b]pyrazol]-41-amine derivatives and similar compounds. The present invention also relates to the compounds of formula (I) for use as Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitors in methods of treatment of e.g. cancer, cardiovascular diseases, immunological disorders, autoimmune disorders, fibrosis, ocular disorders, systemic lupus erythematosus, diabetes, neutropenia, and combinations thereof. The present invention also relates to pharmaceutical compositions containing said compounds and to their methods of synthesis.

专利号:US-5504108-A
优先权日:1990-01-12
标题:Optically pure 4-aryl-2-hydroxytetronic acids
发明人：WITIAK DONALD T; HOPPER ALLEN T
权利人:UNIV OHIO STATE RES FOUND
摘要:The present invention relates to a method for synthesis of optically pure stereogenically labile 4-aryl-2-hydroxytetronic acids from an optically pure aidehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase, and additionally as inhibitors of cyclooxygenase and 5-lipoxygenase. The invention further relates to the pharmaceutical use of such.compounds in the treatment of coronary artery diseases, especially in the treatment and/or prevention of atherosclerosis, and in the treatment of various inflammatory pathologies, especially arthritis.