CAS: 63095-51-2; (R)-4-Propyldihydrofuran-2(3H)-One

相似化合物

63095-60-3 72397-60-5 63095-51-2

上下游产品

cis-4-propyl-5-p-tolylthio-4,5-dihydrofuran-2(3H)-one (2R)-2-propyl-3-(1,3-dithian-2-ylidene)propanol -4-methyl-5-phenyl-2-oxazolidinone(4R,5S)-3-1-oxo-3-(1,3-dithian-2-ylidene)-2-propylpropyl-4-methyl-5-phenyl-2-oxazolidinone (2S,3S)-(E)-butylidene-3,4-dimethyl-2-phenyl-[1,4]oxazepane-5,7-dione 3-(3-methoxy-benzyl)-4-propyl-dihydro-furan-2-one brivaracetam ((2R)-2-[(4R)-2-oxo-4-propyltetrahydro-1H-pyrrol-1-yl]butanamide) ((2S)-2-[(4S)-2-oxo-4-propyltetrahydro-1H-pyrrol-1-yl]butanamide)

正戊酸置于水,双氧水,Sodium Hexamethyldisilazane,Dimethyl Sulfide Borane,三甲基乙酰氯,三乙胺,Lithium Hydroxide体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 72.17H,反应生成 (R)-二氢-4-丙基-2(3H)-呋喃酮
参考文献:手性4-取代基二氢呋喃-2(3H)-酮的制备方法
标题:手性4-取代基二氢呋喃-2(3H)-酮的制备方法
摘要:本发明提供了一种手性4‑取代基二氢呋喃‑2(3H)‑酮的制备方法,包括以下步骤:(A)向化合物(1)的有机溶剂溶液中滴加酰氯(3),反应得到酰氯中间体的溶液,再滴加化合物(2)的有机溶剂溶液进行反应,得到化合物(4);(B)向化合物(4)的有机溶剂溶液中滴加二(三甲基硅基)氨基碱金属盐溶液进行反应,向所得反应液中滴加化合物(5)进行反应,得到化合物(6);(C)化合物(6)与碱反应得到化合物(7);(D)化合物(7)与还原剂发生反应得到化合物(8);其中:R选自芳基,芳甲基或烷基;r1,R2,R3独立地选自烷基;x选自cl,Br或i.本发明的方法工艺简单,可操作性强,易于工业化生产.反应路线如下:.

专利信息

专利号:US-11247977-B2
优先权日:2018-06-22
标题 :Compound and use thereof in synthesis of brivaracetam intermediate and crude drug
发明人：FENG YAN; WANG RUYONG; YE YIZHANG; ZHANG FENGSEN; GONG XUAN; WANG ZHONGHONG; KANG XINSHAN
权利人:FUJIAN HAIXI PHARMACEUTICALS CO LTD
摘要:The present application provides a compound in formula III, and further provides a use of the compound in the synthesis of a Brivaracetam intermediate and a crude drug, and a synthesis method. A raw material involved in the method of the present application is low in costs and easily available; (R)-4-propyl-dihydrofuran-2-ketone having high optical purity can be prepared; complicated separation and purification steps are avoided; costs are reduced, and the method is more applicable to industrial production.

专利号:US-2022064111-A1
优先权日:2019-01-17
标 题:Enantioselective synthesis of brivaracetam and intermediates thereof
发明人：ROY SARABINDU; GHOSH ANGSHUMAN; KUBEER RAMESH DHONDI; PRASAD MUTYALA V V VARA; PAUL GOPAL; GARAI ABHISHEK; CHAKRABORTY SOURAV; HALDAR ANIMESH; YADAW AJAY KUMAR; ROY SUBHO
权利人:CLININVENT RES PVT LTD
摘要:The present invention relates to an improved and economical process for enantioselective synthesis and purification of a novel key intermediate of Brivaracetam. Further, the present invention also relates to a process for the preparation of a chirally pure Brivaracetam of formula I utilizing the said intermediate.

专利号:US-2024343689-A1
优先权日:2021-08-16
标题:Synthesis of brivaracetam
发明人：REDDY DESIREDDY SRINIVASA; REDDY PEKETI SUBBA; REDDY VEDURURI MADHAVA
权利人:OPTIMUS DRUGS PRIVATE LTD
摘要:The present invention relates to a novel compound of(S)-2-((Z)-((R)-4-propyldihydrofuran-2(3H)-ylidene)amino) butanamide and an improved, commercially viable process for preparation of Brivaracetam using(S)-2-((Z)-((R)-4-propyldihydrofur an-2(3H)-ylidene)amino)butanamide.

专利号:US-11518741-B2
优先权日:2018-06-20
标题 :Brivaracetam intermediate, preparation method therefor, and preparation method for brivaracetam
发明人：YANG HANRONG; QI YANTAO; LI TAO; WANG BO
权利人:SHANGHAI PUYI CHEMICAL CO LTD
摘要:The present invention relates to a brivaracetam intermediate, a preparation method therefor, and a preparation method for brivaracetam. The steps of the method for preparing brivaracetam described in the present invention are short and the raw materials are cheap, moreover, the method is simple and highly effective without requiring isomer separation by means of column chromatography or asymmetric synthesis, being suitable for industrial large-scale production. In addition, disclosed by the present invention is a compound as shown in formula (II), which may be used for the synthesis of brivaracetam.

专利号:US-12221413-B2
优先权日:2015-05-25
标 题:Processes to produce brivaracetam
发明人：WANG PENG; LI PIXU; WEI QIANG; LIU YUANHUA
权利人:SUZHOU PENGXU PHARMATECH CO LTD
摘要:The present invention provides a scalable synthesis of enantiomerically pure brivaracetam, and related derivatives.

专利号:JP-7117796-B2
优先权日:2018-06-22
标 题 :its use in the synthesis of compounds and intermediates and drug substances of Brivaracetam