CAS: 93071-75-1; 3-(Trifluoromethoxy)Benzylamine

上下游产品

1-cyano-3-trifluoromethoxybenzene

间三氟甲氧基苯腈置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 作为反应溶剂,化学反应 6.0H,反应生成 3-三氟甲氧基苄胺
参考文献:在具有混合结构的(2,5-二氧杂吡咯烷-1-基)(苯基)乙酰胺中寻找新的抗惊厥药-合成和体内/体外研究
标题:在具有混合结构的(2,5-二氧杂吡咯烷-1-基)(苯基)乙酰胺中寻找新的抗惊厥药-合成和体内/体外研究
摘要:癫痫病属于最常见且使人衰弱的神经系统疾病,具有多种因素的病理生理学和高度的耐药性.因此,为了寻找新的,更有效和/或更安全的治疗方法,我们发现了一系列具有有效抗惊厥特性的原始杂种吡咯烷-2,5-二酮杂化物衍生物.我们应用了优化的偶联反应,产生了几种杂合化合物,它们在广为接受的动物癫痫发作模型中表现出广谱活性,即最大电击(mes)测试和小鼠精神运动性6 Hz(32 Ma)癫痫发作模型.对于化合物30(中位有效剂量(ed50)mes = 45.6 Mg / Kg,Ed50 6 Hz(32 Ma)= 39.5 Mg / Kg,中毒剂量(td50)(罗塔罗德测试),证明了最有效的抗惊厥活性和非常好的安全性)= 162.4 Mg / Kg).抗惊厥药通常在疼痛模型中具有活性,化合物30在福尔马林的滋补性疼痛,辣椒素诱导的疼痛模型和奥沙利铂(oxpt)诱导的神经性疼痛模型中也被证明是有效的.我们的研究表明,最合理的作用机制是30抑制cav1
DOI:10.3390/ijms21228780

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-2012053165-A1
优先权日:2009-03-03
标 题:Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators
发明人：ALLEN MARTIN PATRICK; AM ENDE CHRISTOPHER WILLIAM; BRODNEY MICHAEL AARON; DOUNAY AMY BETH; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SCHWARTZ JACOB BRADLEY; TRAN TUAN PHONG
权利人:ALLEN MARTIN PATRICK; AM ENDE CHRISTOPHER WILLIAM; BRODNEY MICHAEL AARON; DOUNAY AMY BETH; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SCHWARTZ JACOB BRADLEY; TRAN TUAN PHONG; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.