CAS: 99-81-0; 2-Bromo-4'-Nitroacetophenone

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CAS号100-19-6 对硝基苯乙酮 | CAS号940-13-6 Benzene, 1-(bro... | CAS号100-12-9 对乙基硝基苯 | CAS号67-56-1 甲醇 | CAS号100-13-0 4-硝基苯乙烯 | CAS号59938-04-4 1-(1-ethoxyethe... | CAS号586-78-7 对溴硝基苯 | CAS号838-57-3 (4-硝基苯甲酰)乙酸乙酯 | CAS号108791-66-8 1,4-双(4-硝基苯基)丁-... | CAS号100-19-6 对硝基苯乙酮 | CAS号104755-32-0 1-(4-nitropheny... | CAS号110944-98-4 2-iodo-1-(4-nit... | CAS号5425-81-0 2-氨基-1-(4-硝基-苯)... | CAS号3673-53-8 4-(4-氨基-苯基)-噻唑-2-胺 | CAS号33102-81-7 2-甲基-4-(4-硝基苯基)噻唑 | CAS号4740-22-1 2-氨基-1-(4-硝基苯基)... | CAS号1439-43-6 Ethanone,1-(4-n... | CAS号142167-51-9 2-(4-methoxyphe...

4-硝基苯乙烯置于1,3-二溴-5,5-二甲基海因,水体系中,化学反应 4.0H,反应生成 2-溴-4'-硝基苯乙酮
参考文献:1,3-二溴-5,5-二甲基乙内酰脲介导的末端烯烃在水中的氧化酰胺化
标题:1,3-二溴-5,5-二甲基乙内酰脲介导的末端烯烃在水中的氧化酰胺化
摘要:通过用1,3-二溴-5,5-二甲基乙内酰脲处理,然后与分子碘和hcl水溶液反应,将多种末端烯烃在水中以25-86%的产率转化为相应的酰胺.一锅中加入nh 3(或胺).这种无金属和有机溶剂的方案不仅适用于苯乙烯衍生物,而且首次在末端脂族烯烃上效果很好.
DOI:10.1039/c7Ob02329D

专利信息

专利号:WO-2021038581-A1
优先权日:2019-08-30
标题 :A one step synthesis of 2-substituted benzo[b]thiophenes
发明人：SEKAR GOVINDASAMY; POONGUZHALI ELAMVAZHUTHI
权利人:INDIAN INST TECH MADRAS
摘要:The invention pertains to a one step synthesis of 2-substituted benzo[ b ]thiophene of general formula wherein the synthesis of 2-substituted benzo[ b ]thiophenes is by reacting the starting materials substituted or unsubstituted 2-halogenobenzaldehyde and substituted or unsubstituted acetyl/phenacyl bromide with a catalyst, a sulphur source and phase transfer catalyst in an aqueous medium with atmospheric air and at temperature in the range of 25°C-30°C.

专利号:US-9873689-B2
优先权日:2014-11-07
标题:Synthesis of fatostatin based polycyclic compounds
发明人：CANTRELL JR WILLIAM R
权利人:FGH BIOTECH INC
摘要:The present invention relates to methods and strategies for large-scale synthesis of compounds having the chemical structure: n nThe R substituents are H, methyl, isopropyl, benzyl, cyclohexyl, cyclopropylmethyl, methoxy, tert-butyloxycarbonyl, methanesulfonyl, p-toluenesulfonyl, quinolinesulfonyl, or thiophenesulfonyl groups. The method comprises condensing prothionamide with a halo nitroacetophenone to form a nitrophenyl substituted thiazole, reducing the nitro group to form an amine and derivatizing the amine to produce the compound.

专利号:US-2022356182-A1
优先权日:2009-03-27
标题 :Inhibitors of hepatitis c virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:WO-2021038452-A1
优先权日:2019-08-26
标 题 :New therapeutic agents for the treatment of haematological pathologies
发明人：CILIBRASI VINCENZO; SPANO' VIRGINIA; MONTALBANO ALESSANDRA; BARRAJA PAOLA
权利人:UNIV DEGLI STUDI DI PALERMO
摘要:The present invention relates to compounds having a tetracyclic system and the use thereof as new therapeutic agents in the treatment of acute myeloid leukemia (AML), preferably in FLT3/ITD hemizygote patients resistant to conventional therapies. The invention also relates to 5,7-dihydro-4 H -[1,3]thiazolo[4,5- e ]isoindol-2-amine compounds useful as intermediates for the synthesis of tetracyclic imidazo[2',1':2,3][1,3]thiazolo[4,5-e]isoindole compounds.

专利号:US-4230624-A
优先权日:1977-09-02
标 题 :Process for the synthesis of derivatives of the benzofuran, chromene and isochromene type
发明人：LE CORRE MAURICE; HERCOUET ALAIN; BEGASSE BEATRICE
权利人:ANVAR
摘要:The invention relates to a process for the production of therapeutic compounds of the benzofuran, chromene and isochromene type of the general formula; in which formula, R1 and R3=H, lower alkyl, aralkyl or cycloalkyl R2=H or an organic radical and when D= R1 and R3 may represent an organic radical. The process comprising the cyclization in the liquid phase and in the presence of a base a compound of the formula; in which formula; R'=an alkyl, aryl or aralkyl radical and X-=an anion.

专利号:US-11053243-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.