CAS: 13678-58-5; 1-(Methylthio)Butan-2-One

相似化合物

76137-53-6 34047-39-7 20996-62-7

上下游产品

2-methylsulfanyl-butyraldehyde (methylthio)acetyl chloride ethylaluminum dichloride

2-Methylsulfanyl-Butyraldehyde置于硫酸体系中,化学反应生成1-甲硫基-2-丁酮
参考文献:Kirrmann,A. Et Al.,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1962,Vol. 255,P. 728-730
标题:Kirrmann,A. Et Al.,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1962,Vol. 255,P. 728-730

专利信息

专利号:US-3992392-A
优先权日:1973-04-27
标题:Synthesis of indoles from anilines and intermediates therein
发明人：GASSMAN PAUL G
权利人:UNIV OHIO STATE RES FOUND
摘要:Preparing indoles and intermediates therefor by reacting an N-haloaniline with a β-carbonylic hydrocarbon sulfide to form an azasulfonium halide, reacting the azasulfonium halide with a strong base to form a thio-ether indole derivative, and then reducing the thio-ether indole, e.g. with Raney nickel, to form the indole compound. When an acetal or ketal of the β-carbonyl hydrocarbon sulfide is used, the azasulfonium salt is treated with a base, and then with an acid to form the thio-ether indole derivative. When an α-ethyl-β -carbonylic hydrocarbon sulfide is used, the resulting azosulfonium salt reacts with strong base to form a thio-ether indolenine derivative, which on reduction with Raney nickel or complex metal hydrides yields 3-substituted indoles. The aniline may be an aminopyridine to form an aza-indole compound in the process. The azasulfonium salts and thio-ether indole or thio-ether indolenine derivatives can be isolated and recovered from their respective reaction mixtures. The thio-ether-indole and thio-ether indolenine derivatives are useful as intermediates to make the indoles without the thio-ether group. The indoles are known compounds having a wide variety of uses, e.g., in making perfumes, dyes, amino acids, pharmaceuticals, agricultural chemicals and the like.

专利号:US-9090629-B2
优先权日:2010-11-03
标题:Cytotoxic agents comprising new ansamitocin derivatives
发明人：CHARI RAVI V J; WIDDISON WAYNE C; WILHELM SHARON D
权利人:CHARI RAVI V J; WIDDISON WAYNE C; WILHELM SHARON D; IMMUNOGEN INC
摘要:New ansamitocin derivatives bearing a linking group are disclosed. Also disclosed are methods for the synthesis of these new ansamitocin derivatives and methods for their linkage to cell-binding agents. The ansamitocin derivative-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.

专利号:CA-1043337-A
优先权日:1973-04-27
标题 :Synthesis of indoles from anilines and intermediates therein