CAS: 1385018-58-5; N,N-Bis[2-(7-Methoxy-1-Naphthalenyl)Ethyl]Acetamide

上下游产品

acetic anhydride (7-methoxy-1-naphthyl)acetonitrile

乙酸酐,2-(7-甲氧基萘-1-基)乙腈置于氢气体系中,用 溶剂黄146 用作溶剂,45.0 °C,2.0 Mpa 条件下,反应 25.0H,以5.4 G的收率获得阿戈美拉汀二聚体乙酰胺
参考文献:一种制备阿戈美拉汀乙酰二胺的方法
标题:一种制备阿戈美拉汀乙酰二胺的方法
摘要:本发明公开了一种制备阿戈美拉汀乙酰二胺的方法,将溶剂,无水雷尼镍催化剂,(7‑甲氧基‑1‑萘基)乙腈和醋酸酐在氢气条件下,反应釜中加热反应,然后将其减压浓缩,用盐酸和饱和氯化钠洗涤,再用乙酸乙酯结晶,使得阿戈美拉汀乙酰二胺析出,干燥后获得成品.本发明可以制备阿戈美拉汀的工艺杂质阿戈美拉汀乙酰二胺,操作方法简单易得,阿戈美拉汀的收率高,纯度大,本发明为批量生产阿戈美拉汀乙酰二胺提供了一种很好的制备方法.

专利信息

专利号:US-8329947-B2
优先权日:2008-08-05
标 题:Process for the synthesis of agomelatine
发明人：BONTEMPELLI PASCAL; JALENQUES XAVIER; STARCK JEROME-BENOIT; SERY JEAN-PIERRE
权利人:BONTEMPELLI PASCAL; JALENQUES XAVIER; STARCK JEROME-BENOIT; SERY JEAN-PIERRE; SERVIER LAB
摘要:Process for the industrial synthesis of the compound of formula (I)

专利号:WO-2012093402-A1
优先权日:2011-01-04
标题:Processes for the preparation of n-[2-(7-methoxy-1-naphthyl)ethyl]acetamide
发明人：MOHAN RAO DODDA; KRISHNA REDDY PINGILI; ANNA REDDY AMBATI
权利人:SYMED LABS LTD; MOHAN RAO DODDA; KRISHNA REDDY PINGILI; ANNA REDDY AMBATI
摘要:The present invention relates to processes for the synthesis of N-[2-(7-methoxy-l - naphthethyl] acetamide, amorphous form of N-[2-(7-methoxy-l -naphthethyl] acetamide and pharmaceutical compositions thereof.

专利号:WO-2010015744-A1
优先权日:2008-08-05
标题:Novel process for the synthesis of agomelatine

专利号:ZA-200905333-B
优先权日:2008-08-05
标题 :Process for the synthesis of agomelatine

专利号:CN-101643433-B
优先权日:2008-08-05
标题 :A new method for the synthesis of agomelatine

专利号:US-2010036161-A1
优先权日:2008-08-05
标题:Process for the synthesis of agomelatine