CAS: 141645-23-0; (2-Butyl-5-Nitrobenzofuran-3-yl)(4-(3-(Dibutylamino)Propoxy)Phenyl)Methanone

相似化合物

141644-91-9 500791-70-8 141627-42-1

上下游产品

CAS号141645-16-1 2-丁基-3-(4-羟基苯甲酰... | CAS号36421-15-5 N-(3-氯丙基)二丁基胺 | CAS号100-07-2 对甲氧基苯甲酰氯 | CAS号133238-87-6 2-丁基-5-硝基苯并呋喃 | CAS号141627-42-1 2-丁基-3-(4-甲氧基苯甲... | CAS号99-93-4 对羟基苯乙酮 | CAS号1257220-36-2 4'-[3-(di-n-but... | CAS号141626-36-0 决奈达隆 | CAS号141626-57-5 决奈达隆杂质3 | CAS号141644-91-9 (5-氨基-2-丁基-3-苯并...

4-碘乙酰基苯酚置于四(三苯基膦)钯,Potassium Carbonate体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 28.0H,反应生成(2-丁基-5-硝基-3-苯并呋喃基)[4-[3-(二丁基氨基)丙氧基]苯基]甲酮
参考文献:Efficient Syntheses Of Diverse,Medicinally Relevant Targets Planned By Computer And Executed In The Laboratory
标题:Efficient Syntheses Of Diverse,Medicinally Relevant Targets Planned By Computer And Executed In The Laboratory
摘要:The Chematica Program Was Used To Autonomously Design Synthetic Pathways To Eight Structurally Diverse Targets,Including Seven Commercially Valuable Bioactive Substances And One Natural Product. All Of These Computer-Planned Routes Were Successfully Executed In The Laboratory And Offer Significant Yield Improvements And Cost Savings Over Previous Approaches,Provide Alternatives To Patented Routes,Or Produce Targets That Were Not Synthesized Previously.
Doi:10.1016/j.Chempr.2018.02.002

专利信息

专利号:US-2012108828-A1
优先权日:2010-09-09
标题 :Synthesis of dronedarone and salts thereof
发明人：SATHE DHANANJAY GOVIND; PATIL SAMADHAN DAULAT; GAIKWAD UMESH DILIP; RAO MANTRIPRAGADA NARAYANA; SHINDE AJIT BHASKAR
权利人:SATHE DHANANJAY GOVIND; PATIL SAMADHAN DAULAT; GAIKWAD UMESH DILIP; RAO MANTRIPRAGADA NARAYANA; SHINDE AJIT BHASKAR; USV LTD B S D MARG
摘要:The present invention relates to a process for preparation of Dronedarone or pharmaceutically acceptable salts thereof. More particularly, the present invention provides a process for preparation of Dronedarone hydrochloride, without the isolation of Dronedarone base.

专利号:US-6828448-B2
优先权日:2000-12-11
标 题:Methanesulphonamido-benzofuran, preparation method and use thereof as synthesis intermediate
发明人：FINO NOEL; LEROY CORINNE
权利人:SANOFI SYNTHELABO
摘要:The invention relates to 2-butyl-5-(methanesulfonamido)benzofuran, its preparation and its use. n This compound is a synthesis intermediate, in particular for the preparation of dronedarone.

专利号:US-8779201-B2
优先权日:2007-10-02
标题 :Process for preparing benzofurans
发明人：EKLUND LARS
权利人:CAMBREX KARLSKOGA AB
摘要:There is provided a process for the preparation of a compound of formula (I), wherein R 1 , R 2 , R 3 , R 4 , X and Y are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone.

专利号:EP-2428511-A1
优先权日:2010-09-09
标 题:Synthesis of dronedarone and salts thereof

专利号:US-8796489-B2
优先权日:2010-03-02
标题 :Ketobenzofuran derivatives, method for synthesizing same, and intermediates
发明人：BAILLY FRÉDÉRIC; GRIMAUD BERNARD; MALEJONOCK IRINA; VAYRON PHILIPPE
权利人:BAILLY FRÉDÉRIC; GRIMAUD BERNARD; MALEJONOCK IRINA; VAYRON PHILIPPE; SANOFI SA
摘要:The present disclosure relates to ketobenzofuran derivatives of the general formula (I): n nas well as to a method of synthesizing the same by coupling a quinonimine and an enaminone by a Nenitzescu reaction and to the intermediates of the synthesis thereof.

专利号:DE-60103182-T2
优先权日:2000-12-11
标题 :METHANSUFONAMIDO BENZOFURAN, METHOD OF MANUFACTURE AND ITS USE AS A SYNTHESIS INTERMEDIATE