CAS: 142994-45-4; Fmoc-D-3-Pal-Oh

相似化合物

175453-07-3 117142-26-4 64090-98-8

上下游产品

3-pyridinecarboxaldehyde (4Z)-2-methyl-4((pyridin-3-yl)methylene)oxazol-5(4H)-one N-acetyl-(β-3-pyridyl)-DL-alanine N-fluorenylmethyloxycarbonyl-3-pyridylalanine-methyl ester (S)-2-((S)-2-(3-((R)-1-(4-bromophenyl)ethyl)ureido)-3-(pyridin-3-yl)propanamido)-3-methylbutanoic acid (S)-2-((S)-2-(3-(3,4-dichlorobenzyl)ureido)-3-(pyridin-3-yl)propanamido)-3-methylbutanoic acid 2HO-Leu-N-Me-Val-D-Leu-D-3-(3-pyridyl)Ala-3,3-diphenyl-D-Ala-NH2

专利信息

专利号:CN-107056894-B
优先权日:2017-05-26
标 题:A kind of method for fragment method solid-phase synthesis of ganirelix acetate

专利号:US-5434138-A
优先权日:1990-08-04
标 题:Gonadoliberin antagonists
发明人：KOENIG WOLFGANG; SANDOW JUERGEN; KOLAR CENEK
权利人:HOECHST AG
摘要:Peptides of the formula in which X is alkanoyl, A is optionally substituted D-Nal(2), D-Phe or D-Trp, B is optionally substituted D-Phe, C is D-Pal(3) or optionally substituted D-Phe or D-Trp, and D is Tyr or His, E is D-Ser (R1), F is Leu, Trp or Phe, G is L-Ser(R1), H is Gly-NH2, D-Ala-NH2 or Azagly-NH2 and R1 is a glycosyl radical. These peptides have an inhibitory effect on the formation of the gonadotropins lutropin and follitropin and thus also on the synthesis of testo-sterone and estrogen. A process for the preparation of these peptides is described.

专利号:US-2025109170-A1
优先权日:2021-12-01
标 题 :Method for manufacturing ganirelix
发明人：KIM JAE IL; HWANG KOOK SANG; LEE JU YOUNG; KIM DONG MIN; JO EUN JIN; LEE SEUL GI
权利人:ANYGEN CO LTD
摘要:In a method for manufacturing ganirelix, a peptide intermediate A represented by Chemical Formula 19 is obtained, a peptide intermediate B represented by Chemical Formula 21 is obtained, and ganirelix represented by Chemical Formula 13 is obtained through a convergent synthesis of the peptide intermediate A and the peptide intermediate B. Ganirelix can be obtained in high purity and high yield, and the commercial mass-production process therefor is feasible, and also, an economical advantage, that is, the reduction in the production costs compared to conventional technologies, is provided. Furthermore, it is possible to obtain a large quantity of Ganirelix more safely than conventional technologies.

专利号:US-12098218-B2
优先权日:2015-12-17
标题 :Process for the manufacture of degarelix and its intermediates
发明人：RICCI ANTONIO; ZANON JACOPO; CABRI WALTER; GURYANOV IVAN; ORLANDIN ANDREA; BIONDI BARBARA; FORMAGGIO FERNANDO; VISENTINI DARIO
权利人:FRESENIUS KABI IPSUM S R L
摘要:The present invention provides a manufacturing process for preparing a peptide, preferably a decapeptide, such as degarelix, by incorporating p-nitro-phenylalanin in the amino acid sequence preferably during stepwise solid phase synthesis, and converting these into the required amino acids Aph(Hor) and/or D-Aph(Cbm), preferably while attached to a solid phase. The invention further provides intermediates useful in the manufacturing process.

专利号:US-8338565-B2
优先权日:2008-08-20
标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
发明人：LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

专利号:CN-107056894-A
优先权日:2017-05-26
标 题 :A kind of method for the solid-phase synthesis of ganirelix acetate by fragment method