CAS: 149490-61-9; (S)-2-(Butylsulfonamido)-3-(4-(4-(Pyridin-4-yl)Butoxy)Phenyl)Propanoic Acid

上下游产品

4-(4-pyridinyl)butyl chloride hydr°Chloride picoline 4-(pyridin-4-yl)-1-chlorobutane N-n-butylsulfonyl-L-tyrosine ethyl estertirofiban tirofiban hydr°Chloride

L-酪氨酸乙酯置于potassium Carbonate,Potassium Hydroxide体系中,用 水,乙酸乙酯 用作溶剂,化学反应 20.0H,反应生成N-丁磺酰基-(4-(4-吡啶基)丁基)-L-酪氨酸
参考文献:一种盐酸替罗非班的制备工艺
标题:一种盐酸替罗非班的制备工艺
摘要:本发明属于医药化工领域,通过取代,缩合,还原,成盐等反应制备的盐酸替罗非班,具有较高的收率,很好的质量及非常好的稳定性,提供了一种适合实际的工业化大生产的合成工艺.

专利信息

专利号:US-5312923-A
优先权日:1992-02-28
标 题 :Process for preparing fibrinogen receptor antagonists
发明人：CHUNG JOHN Y L; HUGHES DAVID L; ZHAO DALIAN
权利人:MERCK & CO INC
摘要:The invention is a highly efficient synthesis for making compounds of the formula: wherein: R1 is a six membered saturated or unsaturated heterocyclic ring containing one or two heteroatoms wherein the heteroatoms are N; or NR6, wherein R6 is H or C1-10 alkyl; m is an integer from two to six; and R4 is aryl, C1-10 alkyl, or C4-10 aralkyl.