CAS: 223463-14-7; (6-Bromopyridin-3-yl)Boronic Acid

上下游产品

CAS号624-28-2 2,5-二溴吡啶 | CAS号5419-55-6 硼酸三异丙酯 | CAS号73290-22-9 2-溴-5-碘吡啶 | CAS号504-29-0 2-氨基吡啶 | CAS号20511-12-0 2-氨基-5-碘吡啶 | CAS号55717-45-8 2-溴-5-羟吡啶 | CAS号942206-15-7 5,6 -二溴-3,3 -二吡啶 | CAS号942206-14-6 4,6-二溴-2,3-联吡啶 | CAS号942206-16-8 6,2’-二溴-3,4’-联吡啶 | CAS号109-04-6 2-溴吡啶 | CAS号4487-59-6 2-溴-5-硝基吡啶 | CAS号19755-53-4 2-溴-3-硝基吡啶 | CAS号16420-30-7 2-溴-3,5-二硝基吡啶 | CAS号942189-65-3 2-(6-溴吡啶-3-基)嘧啶

2,5-二溴吡啶置于正丁基锂,硼酸三异丙酯体系中,用 乙醚,正己烷 用作溶剂,化学反应 4.0H,以79%的收率获得2-溴吡啶-5-硼酸
参考文献:功能化的吡啶基硼酸及其suzuki交叉偶联反应可产生新的杂芳基吡啶.
标题:功能化的吡啶基硼酸及其suzuki交叉偶联反应可产生新的杂芳基吡啶.
摘要:合成了2-溴-5-吡啶基硼酸2A,2-氯-5-吡啶基硼酸2B,2-甲氧基-5-吡啶基硼酸2C和5-氯-2-甲氧基-4-吡啶基硼酸4.与杂芳基溴化物进行钯催化的交叉偶联反应,生成新的杂芳基吡啶衍生物.已经获得了2A和2B的x射线晶体结构.
Doi:10.1021/jo020388B

专利信息

专利号:WO-2023086799-A1
优先权日:2021-11-09
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:CN-118122382-A
优先权日:2023-11-10
标 题 :A kind of fixed tetraamide hexamethylphenyl cycloferromagnetic nanocomposite material and its synthesis method and application