合成目标产物 4-Iodobenzonitrile 主要起始原料 Ethanol And 4-Bromobenzonitrile
(文献来源)合成步骤主要原料 Ethanol 和 4-Bromobenzonitrile
对氯苯甲腈置于palladium On Activated Charcoal Potassium Iodide体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 48.0H,反应生成 4-碘氰基苯 参考文献:One-Pot Pd/c Catalysed 'domino' Halex And Sonogashira Reactions: A Ligand-And Cu-Free Alternative 标题:One-Pot Pd/c Catalysed 'domino' Halex And Sonogashira Reactions: A Ligand-And Cu-Free Alternative 摘要:介绍了将异相催化与芳基氯底物相结合进行交叉偶联的优势.通过一锅 "Halex"-"Sonogashira "反应,使用异相钯/钯催化剂活化芳基溴化物和抽电子芳基氯化物.该反应无需配体或助催化剂,交叉偶联产物的产率从中等到较高.对溶剂,碱,碘源和催化剂的影响进行了评估.催化剂可重复使用至少六个连续的反应循环.此外,还提出了一种使用催化量 Ki 的变异反应. DOI:10.1039/b513450A
专利号:US-2025179012-A1 优先权日:2022-03-04 标 题:Synthesis of sulfur(vi) compounds and reagents for same 发明人:LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY 权利人:H LEE MOFFITT CANCER CT & RES 摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.
专利号:US-2015239796-A1 优先权日:2014-02-19 标题:One pot synthesis of 18f labeledtrifluoromethylated compounds with difluoro(iodo)methane 发明人:RüHL THOMAS; RISS PATRICK; RAFIQUE WAQAS 权利人:UNIV OSLO 摘要:The present invention relates to compositions and methods for the synthesis of 18 F labeled compounds. In particular, the present invention relates to a copper (I) mediated one pot method for 18 F-trifluoromethylation of aromatic- or heteroaromatic halides with difluoro(iodo)methane (e.g., for use at PET imaging agents).
专利号:US-2024067621-A1 优先权日:2021-02-23 标 题:Polyfluorinated cannabinoid and cannabinoid-like compounds and methods of synthesis and use thereof 发明人:WEAVER JIMMIE D; DAY JON; GROTJAHN SASCHA; SENAWEERA SAMEERA; KOENIG BURKHARD 权利人:WEAVER JIMMIE D; DAY JON; GROTJAHN SASCHA; SENAWEERA SAMEERA; KOENIG BURKHARD; THE BOARD OF REGENTS FOR THE OKLAHOMA AGRICULTURAL AND MECH COLLEGES 摘要:Polyfluorinated compounds are disclosed, including polyfluorinated cannabinoid and cannabinoid-like compounds. Also disclosed are methods of producing the polyfluorinated compounds.
专利号:EP-0479161-A1 优先权日:1990-10-01 标题:Synthesis of heterocyclic compounds 发明人:PERRY ROBERT JAMES 权利人:EASTMAN KODAK CO 摘要:A new synthetic method is reported in which 2-arylbenz(ox,imid,thi)azoles can be prepared by the palladium catalyzed condensation of aromatic halides with o-amino(phenol, aniline, thiophenol)s followed by dehydrative cyclization. This method is tolerant of a wide variety of functional groups on either aromatic ring and gives good to excellent yields of products.
专利号:US-8013157-B2 优先权日:2006-12-20 标题:Synthesis of unsaturated piperidines from piperidones with a silyl reagent 发明人:MANI NEELAKANDHA S; MORRILL CHRISTIE 权利人:JANSSEN PHARMACEUTICA NV 摘要:Syntheses of unsaturated piperidines from piperidones through a silyl piperidine reagent via the Shapiro reaction and palladium-catalyzed cross-coupling reactions with organo halides.
专利号:US-11192912-B1 优先权日:2020-10-15 标 题 :Synthesis of biaryl ketones and biaryl diketones via carbonylative Suzuki-Miyaura coupling reactions catalyzed by bridged bis(N-heterocyclic carbene)palladium(II) catalysts 发明人:EL ALI BASSAM; MANSOUR WASEEM; FETTOUHI MOHAMMED 权利人:UNIV KING FAHD PET & MINERALS; SAUDI ARABIAN OIL CO 摘要:This disclosure relates to bridged bis(N-heterocyclic carbene)palladium(II) complexes, methods of preparing the complexes, and methods of using the complexes in Suzuki-Miyaura coupling reactions.