CAS: 4021-12-9; 3-Methylisonicotinic Acid

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7584-05-6 116985-92-3 38070-73-4

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3-甲基-4-氰基吡啶置于sodium Hydroxide体系中,化学反应生成 3-甲基-4-甲酸嘧啶
参考文献:甲基吡啶衍生物的合成.i.4-取代的3-甲基吡啶的合成.
标题:甲基吡啶衍生物的合成.i.4-取代的3-甲基吡啶的合成.
摘要:将 3-甲基吡啶 1-氧化物与磷酰氯加热反应生成 4-氯-3-甲基吡啶,4-位上的氯被腈取代,然后进一步转化为羧基,乙氧基羰基或苯甲酰基.
DOI:10.1248/cpb1953.5.78

专利信息

专利号:US-9676783-B2
优先权日:2008-10-22
标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
权利人:ARRAY BIOPHARMA INC
摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

专利号:US-2010234339-A1
优先权日:2007-05-31
标 题 :Silver(i) compounds and their use in pharmaceutical compositions for the treatment,prophylaxis and prevention of infections
发明人：OEHRSTROEM LARS; LANGER VRATISLAV; ABU-YOUSSEF MORSY A M; YOURSY GOHAR; MASSOUD ALSHIMA A A
权利人:CSE INCUBATION AB
摘要:The present invention provides new Ag(I) complexes with derivatives of nicotinic acid, nicotinamide and related pyridine ligands, and pharmaceutical compositions comprising such Ag(I) complexes for use in the treatment, prophylaxis and prevention of infections. The invention further provides a solvent free method for the synthesis of Ag(I) complexes containing substituted pyridines, pyrazines and pyrimidines as ligands.

专利号:WO-2010126607-A2
优先权日:2009-04-30
标 题:Synthesis of tetracyclines and intermediates thereto

专利号:US-5521179-A
优先权日:1991-04-18
标题 :Heterocyclic amides
发明人：BERNSTEIN PETER R; SHAW ANDREW; THOMAS ROYSTON M; WARNER PETER; WOLANIN DONALD J
权利人:ZENECA LTD
摘要:The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic amides, processes for preparing the heterocyclic amides, pharmaceutical compositions containing such heterocyclic amides and methods for their use.

专利号:DK-2725028-T3
优先权日:2008-10-22
标题:Substituted pyrazolo [1,5-a] pyrimidine compounds as intermediates in the synthesis of kinase inhibitors TRK

专利号:EP-2424834-A2
优先权日:2009-04-30
标题:Synthesis of tetracyclines and intermediates thereto