专利号:WO-2020248279-A1 优先权日:2019-06-14 标 题 :Continuous synthesis method for substituted benzoate organic matter 发明人:HONG HAO; LU JIANGPING; ZHANG ENXUAN; LIU ZHIQING; LI CHAO 权利人:JINLIN ASYMCHEM LABORATORIES CO LTD 摘要:The present invention provides a continuous synthesis method for a substituted benzoate organic matter. The continuous synthesis method comprises: in the presence of a catalyst and an organic solvent, continuously feeding an organic matter as represented by formula (I) and oxygen into a continuous reaction device for continuous oxidation reaction to obtain a substituted benzoate organic matter, and performing continuous discharge, wherein the substituted benzoate organic matter has a structure as represented by formula (II). Oxygen is a green reagent, and is cheap and easy to obtain; the present invention would not produce a large amount of waste gas, waste water, and waste residues after the completion of reaction, and the system is easy to handle. The use of continuous reaction operation can reduce the risk of solvent flash evaporation explosion due to high concentration oxygen in batch reactions. Under the same oxidation conditions, the use of a continuous preparation process can reduce the escape of oxygen, greatly increase the utilization of oxygen, simplify the operation, and improve the reaction safety and the yield of substituted benzoate organic matters.
专利号:US-12419304-B2 优先权日:2019-09-23 标 题:Aryl sulfide comprising benzylamine, synthesis method and application thereof 发明人:LI NING; LIU YINGSHUAI; LI XIANJIANG; XIAO JIAN; LIU XIANGWEI; LIU RUIBIN; SHENG GUOZHU; FENG RUIJIE; XIANG XIAOZHONG; CUI YINGRUI; CHEN YU; WANG SHILING 权利人:SHANDONG KANGQIAO BIO TECH CO LTD 摘要:The invention belongs to the technical field of pesticides and specifically relates to an aryl sulfide containing a benzylamine structure, a synthesis method therefor, and an application thereof. The aryl sulfide is denoted as compound I. Also provided is an agriculturally acceptable salt of the aryl sulfide. The compound represented by formula I shows excellent effects on various harmful organisms, especially spider mites represented by Tetranychus cinnabarinus, Tetranychus urticae, Tetranychus Kanzawai Kishida, Panonychus citri , etc., and can be used for controlling all kinds of harmful mites.
专利号:US-2024247311-A1 优先权日:2022-12-22 标题 :Palladium catalyst compositions and methods for sequencing by synthesis 发明人:PEDROSO CASSIO; PANIGRAHI ADYASHA; MARIANI ANGELICA; CARVER ADAM; HOURS RAPHAËLLE; CHANDRACHUD PREETI; FRANCAIS ANTOINE; APSUNDE TUSHAR; HATTINGH KATHRYN; BEECH TIMOTHY; SOLIS DANIEL; LAWRENCE ELLIOT J 权利人:ILLUMINA INC 摘要:The present application relates to palladium catalyst composition and uses in sequencing by synthesis. In particular, the Pd catalyst composition comprises one or more macrocycles (e.g., cyclodextrin or analogs thereof) as additives for improving thermal or oxidative stability of the active Pd(0) species.
专利号:US-2011256592-A1 优先权日:2008-12-12 标题:Use of cyclodextrins to improve the specificity, sensitivity and yield of nucleic acid amplification reactions 发明人:BECKERS MARIE-CLAIRE; CRONET PHILIPPE; VITALE ADELINE; COLLETTE ERIC; GULLUKAYA ARZU 权利人:EUROGENTEC SA 摘要:The invention is directed to methods for in vitro DNA synthesis catalysed by a DNA polymerase using cyclodextrins. The invention also relates to methods, compositions and kits comprising cyclodextrins for the amplification of a nucleic acid. The use of cyclodextrins improves the specificity, sensibility and/or yield of the amplification reaction. The invention is related more particularly to kits, compositions and methods for carrying out PCR reactions comprising a cyclodextrin.
专利号:EP-2373811-A1 优先权日:2008-12-12 标题 :Use of cyclodextrins to improve the specificity, sensitivity and yield of nucleic acid amplification reactions 发明人:BECKERS MARIE-CLAIRE; CRONET PHILIPPE; VITALE ADELINE; COLLETTE ERIC; GUELLUEKAYA ARZU 权利人:EUROGENTEC SA 摘要:The invention is directed to methods for in vitro DNA synthesis catalysed by a DNA polymerase using cyclodextrins. The invention also relates to methods, compositions and kits comprising cyclodextrins for the amplification of a nucleic acid. The use of cyclodextrins improves the specificity, sensibility and/or yield of the amplification reaction. The invention is related more particularly to kits, compositions and methods for carrying out PCR reactions comprising a cyclodextrin.
专利号:CN-104844521-A 优先权日:2014-02-13 标 题:A new method for the synthesis of anti-prostate cancer drug enzalutamide
[参考文献]: Tomoko Hayashi, Et Al. 3-Hydroxyanthranilic Acid Inhibits Pdk1 Activation And Suppresses Experimental Asthma By Inducing T Cell Apoptosis. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18619-24.
合成参考文献
摘要:Wang, K.; Wang, J., Science of Synthesis, (2022) , 7.