CAS: 529-20-4; 2-Methylbenzaldehyde

上下游产品

CAS号4389-39-3 o-Toluoin | CAS号111681-88-0 2-hydroxy-2-(2-... | CAS号134-81-6 联苯甲酰 | CAS号105702-07-6 2-(2-methylphen... | CAS号112093-21-7 2-Methyl-N-(2-m... | CAS号5955-73-7 邻甲基苯甲酰氰 | CAS号527-85-5 2-甲基苯甲酰胺 | CAS号529-19-1 邻甲基苯腈 | CAS号39627-61-7 7-甲基-1-茚酮

邻二甲苯置于2-碘酰基苯甲酸体系中,用 氟苯,二甲基亚砜 作为反应溶剂,化学反应 16.0H,以82%的收率获得产物2-甲基苯甲醛
参考文献:有机合成中的碘 (V) 试剂.第 4 部分.O-碘氧基苯甲酸作为基于单电子转移的氧化过程的化学特异性工具
标题:有机合成中的碘 (V) 试剂.第 4 部分.O-碘氧基苯甲酸作为基于单电子转移的氧化过程的化学特异性工具
摘要:O-碘氧基苯甲酸 (Ibx) 是一种容易获得的高价碘 (V) 试剂,被发现在与羰基官能团相邻(形成 α,β-不饱和羰基化合物)以及苄基和相关碳中心进行氧化方面非常有效(形成共轭芳香羰基体系).机理研究得出的结论是,这些新反应是由从底物到 Ibx 的单电子转移 (Set) 引发的,以形成自由基阳离子,该阳离子进一步反应以产生最终产物.反应条件的微调允许在多功能底物内进行显着的选择性转化,将该试剂的状态提升为非常有用的化学选择性氧化剂.
DOI:10.1021/ja012127+

专利信息

专利号:US-2010099894-A1
优先权日:2006-10-09
标 题 :Method for the Synthesis of Cyclic Acetals by the Reactive Extraction of a Polyol in a Concentrated Solution
发明人：DUBOIS JEAN-LUC; IBORRA CHORNET SARA; VELTY ALEXANDRA I LUCIENNE; CORMA CANOS AVELINO
权利人:DUBOIS JEAN-LUC; IBORRA CHORNET SARA; VELTY ALEXANDRA I LUCIENNE; CORMA CANOS AVELINO
摘要:A method for the synthesis of cyclic acetals comprises reacting at least one carbonyl-function compound selected from aldehydes, ketones, and/or linear acetals, on a polyol in a concentrated aqueous solution exceeding 20 wt % in a reactor containing an acidic catalyst. The carbonyl-function compound is selected so that the cyclic acetal obtained has a water solubility lower than 20000 mg/kg. During the catalytic reaction for the cyclic acetal synthesis, at least one portion of the organic phase containing the cyclic acetal is separated. The acidic catalysis is either homogeneous when using a water-soluble strong acid, or heterogeneous when using a solid acid such as a resin, a zeolite, or any appropriately acidified solid. The extractive reaction method can be used for obtaining high conversions and selectivity.

专利号:US-5549974-A
优先权日:1994-06-23
标题:Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
发明人：HOLMES CHRISTOPHER P
权利人:AFFYMAX TECH NV
摘要:The invention provides an efficient and versatile method for the combinatorial synthesis and screening of libraries of 4-thiazolidinones, metathiazanones, and derivatives thereof. In order to expediently synthesize a combinatorial library of derivatives based upon these core structures, a general methodology for the solid phase synthesis of these derivatives is also provided. Arrays of thiazolidinones, metathiazanones, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antihistaminic, or antimicrobial activity or use in the treatment of inflammation, hypertension, renal failure, congestive heart failure, uremia and other conditions can be prepared using this method.

专利号:EP-0439404-B1
优先权日:1990-01-25
标题 :Preparation of 2-(2'-thienyl) alkylamines and derivatives thereof and synthesis of 4,5,6,7- thieno [3,2-c] pyridine derivatives therefrom
发明人：KHATRI HIRALAL N; DEHOFF BRADLEY S
权利人:SANOFI SA
摘要:An improved process for the synthesis of 2-(2 min -thienyl)ethylamine from suitably functionalized derivatives of 2-(2 min -thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2 min -thienyl)ethylamine produced by this process is advantageously converted to the carbamic acid salt, which is suitably reconverted to 2-(2 min -thienyl)ethylamine, a useful intermediate in the synthesis of ticlopidine.

专利号:US-5484949-A
优先权日:1993-01-29
标题:Method for the synthesis of α β-unsaturated ketones
发明人：TSUKASHIMA KEIICHI; NAKAJIMA MASASHI; FUJIMARU MASAYOSHI; SUZUKI KENJI
权利人:NIPPON SODA CO
摘要:The present invention relates to a method for the synthesis of alpha , beta -unsaturated ketones which comprises, in the method for the synthesis of alpha , beta -unsaturated ketones represented by general formula reacting aldehydes represented by general formula R1CHO (where R1 is as defined above) with alkali metal salt of acetoacetic acid represented by general formula sence as a catalyst of 3-azabicyclo[3,2,2]nonane, a cyclic secondary amine represented by general formula (1) (1) a cyclic secondary amine represented by general formula (2) (2) (where, l is 1 or more and up to 6, a ring with N is a 6-membered, 7-membered or 8-membered ring, the two neighbors of N are methylene, R3 is a lower alkyl group, its substitution position is at a carbon atom other than two those adjacent to N, and is an alicyclic group or a phenol group), or a secondary amine represented by general formula (3) CH3NHCH2R4(3) in a mixuture solvent of water and water-insoluble organic solvent, while keeping the pH constant with mineral acid, and by adjusting an amount of water.

专利号:US-10730904-B2
优先权日:2012-11-14
标 题:Method for liquid-phase synthesis of nucleic acid
发明人：NONOGAWA MITSURU; NAGATA TOSHIAKI; SAITO HIDEKI; YASUMA TSUNEO
权利人:TAKEDA PHARMACEUTICALS CO
摘要:In this method, an oligonucleotide represented by formula (II) [wherein Y 1 , Q, Base, r and r′ are each as defined in claim 1 ] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3 and n are each as defined in claim 1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

专利号:US-6524446-B2
优先权日:2001-03-27
标 题 :Process for synthesis of a porphyrin compound using a molecular sieve catalyst under microwave irradiation
发明人：KULKARNI SHIVANAND JANARDAN; RAGHAVAN KONDAPURAM VIJAYA; MOTKURI RADHA KISHAN; NAGABANDI SRINIVAS
权利人:COUNCIL SCIENT IND RES
摘要:The present invention provides an improved process for synthesis of porphyrin compounds of the general formula 1 n from pyrrole and aromatic aldehyde over zeolite molecular sieve catalysts using microwave heating, (solvent free) to provide an eco-friendly, economical, faster and selective heterogeneous method.