CAS: 694-28-0; 2-Chlorocyclopentanone

上下游产品

cyclopentanone (1S,5R)-6-Oxa-bicyclo[3.1.0]hexane N-chloro-succinimide 1-(trimethylsilyloxy)cyclopentene 2-Methylcyclopentanone 4,5,6,7-tetrahydro-cyclopenta[1,4]thiazin-3-one H-cyclopentathiazole5,6-dihydro-4H-cyclopentathiazole 3,4,5,6-tetrahydro-cyclopentathiazol-2-one

环戊酮置于ammonium Cerium(Iv) Nitrate体系中,化学反应 4.0H,以85%的收率获得产物2-氯环戊酮
参考文献:用离子液体,[acmim]X 和硝酸铈铵 (Can) 卤化羰基化合物
标题:用离子液体,[acmim]X 和硝酸铈铵 (Can) 卤化羰基化合物
摘要:离子液体乙酰甲基咪唑鎓卤化物 ([acmim]X) 与硝酸铈铵结合可促进多种酮和 1,3-酮酯在 α 位的卤化.离子液体在此既充当试剂又充当反应介质,因此该反应不需要任何有机溶剂或常规卤化剂.当使用自由基猝灭剂 Tempo 时,反应完全停止.还提出了一种似是而非的激进机制.
DOI:10.1071/ch07061

专利信息

专利号:US-5780603-A
优先权日:1996-11-15
标题:Combinatorial synthesis of carbohydrate libraries
发明人：HINDSGAUL OLE
权利人:SYNSORB BIOTECH INC
摘要:Disclosed are methods for synthesizing very large collections of diverse thiosaccaride derivatives optionally attached to a solid support. Also disclosed are libraries of diverse thiosaccaride derviatives.

专利号:US-5965719-A
优先权日:1996-11-15
标 题:Combinatorial synthesis of carbohydrate libraries
发明人：HINDSGAUL OLE
权利人:SUNSORB BIOTECH INC
摘要:Disclosed are methods for synthesizing very large collections of diverse thiosaccharide derivatives optionally attached to a solid support. Also disclosed are libraries of diverse thiosaccharide derivatives.

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:WO-9822487-A1
优先权日:1996-11-15
标 题 :Combinatorial synthesis of carbohydrate libraries

专利号:CN-107698431-A
优先权日:2017-09-26
标题 :Synthesis of 1‑Chloro‑1‑Acetylcyclopropane by Microreactor Method

专利号:EP-0938492-A1
优先权日:1996-11-15
标 题 :Combinatorial synthesis of carbohydrate libraries