CAS: 7693-44-9; 4-Bromophenyl Carbonochloridate

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CAS号75-44-5 光气 | CAS号106-41-2 对溴苯酚 | CAS号298198-52-4 (4-bromophenyl)...

4-溴苯酚,三光气置于n,N-二乙基苯胺体系中,用 甲苯 作为反应溶剂,化学反应 2.0H,反应生成 对溴氯甲酸苯酯
参考文献:可见光诱导的分子内c(sp 2)-h胺化和叠氮基甲酰胺通过三重态硝基途径的叠氮化
标题:可见光诱导的分子内c(sp 2)-h胺化和叠氮基甲酰胺通过三重态硝基途径的叠氮化
摘要:邻烯丙基苯基叠氮基甲酸酯的催化分子内c-h氨基化和叠氮化反应已在可见光照射下完成,为合成有用的苯并恶唑酮和[5.1.0]双环氮丙啶提供了温和,清洁和有效的方法.机理研究表明,三重态氮烯起反应性中间体的作用.与烷基烯烃叠氮化≫缺电子烯烃叠氮化~c(sp 2)-h胺化≫ C(sp 3)-h胺化反应的化学选择性,在理解可见光方面可能具有指导意义诱导的三重态氮转化反应.
DOI:10.1021/acs.Orglett.8B01980

专利信息

专利号:US-5521179-A
优先权日:1991-04-18
标题 :Heterocyclic amides
发明人：BERNSTEIN PETER R; SHAW ANDREW; THOMAS ROYSTON M; WARNER PETER; WOLANIN DONALD J
权利人:ZENECA LTD
摘要:The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic amides, processes for preparing the heterocyclic amides, pharmaceutical compositions containing such heterocyclic amides and methods for their use.