CAS: 85838-94-4; Tert-Butyl 5,6-Dihydropyridine-1(2H)-Carboxylate

相似化合物

18513-79-6 66207-23-6 159503-91-0

上下游产品

CAS号694-05-3 1,2,5,6-四氢吡啶 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号118811-07-7 4-(甲苯-4-磺酰氧)哌啶-... | CAS号141699-59-4 1-B°C-4-甲烷磺酰氧基哌啶 | CAS号129888-60-4 N-B°C-3-甲磺酰氧基哌啶 | CAS号65-71-4 胸腺嘧啶 | CAS号1211531-06-4 N-B°C-(3-buteny... | CAS号123-91-1 1,4-二氧六环 | CAS号109384-19-2 N-B°C-4-羟基哌啶 | CAS号1211531-07-5 tert-butyl di(b... | CAS号224779-27-5 叔-丁基 3-羟基-1,2,3... | CAS号156496-89-8 5-氧代-5,6-二氢吡啶-1... | CAS号161157-50-2 1-B°C-3,4-环氧哌啶

Ethyl 1,2,3,6-Tetrahydropyridine-1-Carboxylate置于氢氧化钾,一水合肼体系中,用 氯仿,乙二醇 作为反应溶剂,化学反应 13.5H,反应生成 N-Boc-1,2,3,6-四氢吡啶
参考文献:新型含取代哌啶的氟喹诺酮类化合物的合成和抗菌活性.
标题:新型含取代哌啶的氟喹诺酮类化合物的合成和抗菌活性.
摘要:描述了在c-7位具有取代哌啶环的新型氟喹诺酮类抗菌剂的设计和合成.大多数新化合物显示出很高的体外抗菌活性.它们中的几个对革兰氏阳性生物体显示出显着的活性,其活性比吉西沙星,利奈唑胺和万古霉素强.
DOI:10.1016/j.Bmcl.2007.05.093

专利信息

专利号:US-10906033-B2
优先权日:2016-03-28
标题 :Synthesis and application of chiral substituted polyvinylpyrrolidinones
发明人：HUA DUY H
权利人:UNIV KANSAS STATE
摘要:Chiral polyvinylpyrrolidinone (CSPVP), complexes of CSPVP with a core species, such as a metallic nanocluster catalyst, and enantioselective oxidation reactions utilizing such complexes are disclosed. The CSPVP complexes can be used in asymmetric oxidation of diols, enantioselective oxidation of alkenes, and carbon-carbon bond forming reactions, for example. The CSPVP can also be complexed with biomolecules such as proteins, DNA, and RNA, and used as nanocarriers for siRNA or dsRNA delivery.

专利号:WO-0027817-A1
优先权日:1998-11-10
标 题:Oxazolidinones useful as alpha 1a adrenoceptor antagonists
发明人：NERENBERG JENNIE B; BOCK MARK G; PATANE MICHAEL A; SELNICK HAROLD G
权利人:MERCK & CO INC; NERENBERG JENNIE B; BOCK MARK G; PATANE MICHAEL A; SELNICK HAROLD G
摘要:Novel hydroxymethyl- and alkoxymethyl-oxazolidinone compounds and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered uring flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia can be achieved.

专利号:WO-0027827-A1
优先权日:1998-11-10
标题:Oxazolidinones useful as alpha 1a adrenoceptor antagonists
发明人：NERENBERG JENNIE B; BOCK MARK G; SELNICK HAROLD G; PAYNE LINDA
权利人:MERCK & CO INC; NERENBERG JENNIE B; BOCK MARK G; SELNICK HAROLD G; PAYNE LINDA
摘要:Novel oxazolidinone compounds and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia can be achieved.

专利号:US-6228870-B1
优先权日:1998-11-10
标 题:Oxazolidinones useful as alpha 1a adrenoceptor antagonists
发明人：NERENBERG JENNIE B; BOCK MARK G; PATANE MICHAEL A; SELNICK HAROLD G
权利人:MERCK & CO INC
摘要:Novel hydroxymethyl- and alkoxymethyl-oxazolidinone compounds and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia can be achieved.

专利号:US-6235759-B1
优先权日:1998-10-29
标 题 :Dihydropyridinones and pyrrolinones useful as alpha 1A adrenoceptor antagonists
发明人：BARROW JAMES C; NANTERMENT PHILIPPE G; SELNICK HAROLD G
权利人:MERCK & CO INC
摘要:Novel dihydropyridinone and pyrrolinone compounds and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia can be achieved.

专利号:US-6319932-B1
优先权日:1998-11-10
标 题 :Oxazolidinones useful as alpha 1A adrenoceptor antagonists
发明人：NERENBERG JENNIE B; BOCK MARK G; SELNICK HAROLD G; PAYNE LINDA
权利人:MERCK & CO INC
摘要:Novel oxazolidinone compounds and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia can be achieved.