专利号:EP-1472258-B1 优先权日:2002-03-26 标 题:Method for the synthesis of porphyrins and calix(4)pyrroles 发明人:POTHURI SITA DEVI; KONDAPURAM VIJAYA RAGHAVAN; KULKARNI SHIVANAND JANARDAN; MOTKURI RADHA KISHAN; VIPPAGUNTA RADHA RANI; MURTY MAMIDANNA RAMA VENKATA S 权利人:COUNCIL SCIENT IND RES 摘要:The present invention provides an innovative method based on reaction cum separation on single plate concept for efficient evaluation of porphyrins, calix(4)pyrroles and allied macrocycles by in-situ synthesis from pyrrole with aromatic aldehydes and ketones over zeolite based molecular sieve catalysts as sorbents in thin layer chromatography (TLC) using microwave heating. This glass beacked zeolite coated TLC plate acts as a micro reactor as well as separator for the in-situ synthesis and chromatographic separation of macrocycles. The process is simple, economical, rapid, selective and finds a possible application in high throughput parallel synthesis and screening on a single micro plate employing microwave irradiation.
专利号:US-8383835-B2 优先权日:2007-12-26 标 题 :Process for the production of cyclic diesters of alpha-hydroxyacids 发明人:WAJC SAMUEL J; WAUTIER HENRI 权利人:KTANTON LTD; WAJC SAMUEL J; WAUTIER HENRI 摘要:Process for the synthesis of a cyclic diester of an alpha-hydroxyacid, comprising the following steps:n an alkalino-earth salt of the corresponding alpha-hydroxyacid is mixed with said alpha-hydroxyacid and water; the mixture is treated by evaporation-crystallization, so that a hydrate of the alkalino-earth salt of the linear dimer of the corresponding alpha-hydroxyacid precipitates; the hydrated salt is dehydrated to give the corresponding anhydrous salt; and the anhydrous salt is pyrolyzed, releasing the cyclic diester of the corresponding alpha-hydroxyacid and leaving the alkalino-earth hydroxide as solid residue.
专利号:US-12428738-B2 优先权日:2019-10-29 标 题 :Electrochemical synthesis of cementitious compounds 发明人:HOUCHINS GREGORY; VISWANATHAN VENKATASUBRAMANIAN 权利人:UNIV CARNEGIE MELLON 摘要:In some aspects, the present disclosure pertains to methods for the electrochemical production of calcium silicate compounds in an electrochemical cell that comprises (a) a Ca-based electrode that comprises calcium metal or an inorganic calcium material, (b) an SiOx-based electrode that comprises a SiOx material, where x ranges from 1 to 2, and (c) a liquid electrolyte disposed between the Ca-based electrode and the SiOx-based electrode. In these methods, the electrochemical cell is operated under conditions such that calcium cations are produced at the Ca-based electrode and one or more calcium silicate (Ca—Si-oxide) compounds are produced at the SiOx-based electrode. In other aspects, the present disclosure pertains to systems for the electrochemical production of calcium silicate compounds.
专利号:US-2012136015-A1 优先权日:2009-04-13 标题:Process for preparation of endothelial receptor antagonist (bosentan) 发明人:JOSHI SHREERANG; KHAN RASHID; BENDRE DEVEN; SALUNKHE DADASAHEB; GUDEKAR SANKET 权利人:JOSHI SHREERANG; KHAN RASHID; BENDRE DEVEN; SALUNKHE DADASAHEB; GUDEKAR SANKET; SANDOZ AG 摘要:The present invention relates to processes for the preparation of an endothelial receptor antagonist. The present invention particularly relates to synthesis of 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzene sulfonamide (bosentan).
专利号:US-5981748-A 优先权日:1995-06-07 标题:Synthesis of optically pure compounds useful as GARFT inhibitors and their intermediates 发明人:VARNEY MICHAEL D; ROMINES WILLIAM H; PALMER CYNTHIA L 权利人:AGOURON PHARMA 摘要:The invention relates to methods of making compounds of the formula VII ##STR1## and their enantiomers, where Ar is a substituted or unsubstituted five- or six-membered aromatic group and B is either an amino acid linked through the amino portion to form an amide or a C 1 -C 6 alcohol linked through the alcohol portion to form an ester. These compounds are advantageously employed as intermediates to prepare optically pure compounds that are active GARFT inhibitors. In one method, a compound of the formula ##STR2## is reacted with a compound of the formula ##STR3## where X is a halogen.
专利号:US-9085487-B2 优先权日:2008-04-30 标 题 :Large scale production of carbon nanotubes in portland cement 发明人:ELETO DA SILVA EDELMA; ORLANDO LADEIRA LUIZ; GRIBEL LACERDA RODRIGO; DE OLIVEIRA SÉRGIO; SANTAROSA FERLAUTO ANDRÉ; LORENÇON EUDES; DE SOUSA Ã?VILA ERICK 权利人:ELETO DA SILVA EDELMA; ORLANDO LADEIRA LUIZ; GRIBEL LACERDA RODRIGO; DE OLIVEIRA SÉRGIO; SANTAROSA FERLAUTO ANDRÉ; LORENÇON EUDES; DE SOUSA Ã?VILA ERICK; UNIV MINAS GERAIS 摘要:The present invention describes a chemical vapor-phase deposition for carbon nanotube synthesis in which cement clinker is used as a ceramic matrix for anchoring transition-metal nanoparticles. Using cement clinker as nanoparticle anchoring base of transition metals allows carbon nanotubes to be generated on cement clinker particles and grains, in this way producing a kind of cement that is nanostructured with carbon nanotubes. By this process, the carbon nanotube synthesis and integration to clinker are carried out in just one continuous and large-scale stage. The process described herein can be applied to conventional cement industry whose production may be rated as tons per day. The present invention also proposes—as part of the carbon nanotube synthesis on cement clinker—several enrichment alternatives of cement clinker by using transition metals for producing such nanostructured composite, which may or not be integrated to the conventional cement industry.
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