Bis-(2-Methoxy-Ethyl)-Ether ; Compound With Sodium Borate 反应生成二乙二醇二甲醚 参考文献:A Study Of Solvents For Sodium Borohydride And The Effect Of Solvent And The Metal Ion On Borohydride Reductions1 标题:A Study Of Solvents For Sodium Borohydride And The Effect Of Solvent And The Metal Ion On Borohydride Reductions1 摘要: Doi:10.1021/ja01628A044
专利号:US-8822702-B2 优先权日:2002-12-20 标 题 :Synthesis of amines and intermediates for the synthesis thereof 发明人:BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL 权利人:BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL; BASF SE 摘要:The invention relates in a first embodiment to a method for the manufacture of esters of the formula I, n nor especially of amides of the formula II,n n nwherein the symbols have the meanings given in the specification, as well as other intermediates and compounds useful in the synthesis of tryptamines and other substances mentioned in the title. The synthesis methods and intermediates are useful in the synthesis of pharmaceuticals.
专利号:US-6184168-B1 优先权日:1997-09-22 标题:Synthesis of 1,4-trans-polybutadiene using a lanthanide organic acid salt catalyst 发明人:LYNCH THOMAS J 权利人:BRIDGESTONE CORP 摘要:The invention provides a catalyst composition, comprising: (a) an organolithium compound; and, (b) an organic acid salt of lanthanide series element; wherein: (1) only components (a) and (b) are required to promote the synthesis of 1,4-trans-polybutadiene; (2) the ratio of component (a) to component (b) is selected to maximize formation of the trans structure of said 1,4-trans-polybutadiene; and, (3) components (a) and (b) are selected for enabling further diblock synthesis. The invention further contemplates a process for using the catalyst to synthesize 1,4-trans-polybutadiene and other polymers and copolymers having trans configuration in the conjugated diene monomer contributed units.
专利号:WO-2021035382-A1 优先权日:2019-08-23 标题:Method forcontinuous synthesis of 2-cyclopentene-1-one 发明人:HONG HAO; LU JIANGPING; BAO DENGHUI; YUAN LONG; WANG BO 权利人:LIAONING ASYMCHEM LABORATORIES CO LTD 摘要:Provided is a method for the continuous synthesis of 2-cyclopenten-1-one. The continuous synthesis method comprises: loading a catalyst in a continuous reaction device, then continuously conveying cyclopentene, an oxidant and a solvent into the continuous reaction device for an oxidation reaction, and continuously discharging 2-cyclopentene-1-one. In the presence of the catalyst and the solvent, cyclopentene is used as a starting material, and same is directly oxidized by the oxidant, which can avoid the generation of a large amount of halogen-containing three wastes; at the same time, the entire continuous synthesis process is carried out in the continuous reaction device, which can effectively inhibit the occurrence of safety risks during scale-up production; in addition, after the reaction is complete, the product system of the oxidation reaction can be simply concentrated to obtain the target product (2-cyclopenten-1-one). Thus, the purity (up to 98% and above) and separation rate (up to 79%) of the product are greatly improved, and production can be easily scaled up.
专利号:US-8084007-B2 优先权日:2004-01-30 标题 :Methods of synthesis of isotropically enriched borohydride and methods of synthesis of isotropically enriched boranes 发明人:SPIELVOGEL BERNARD; COOK KEVIN S 权利人:SPIELVOGEL BERNARD; COOK KEVIN S; SEMEQUIP INC 摘要:The invention provides new methods for the synthesis of isotopically enriched metal borohydrides, metal tetrahydroundecaborate salts, and decaborane from isotopically enriched 10 B-boric acid or 11 B-boric acid. The invention is particularly useful for synthesis of isotopically enriched sodium or lithium borohydride, MB 11 H 14 (where M is Li, Na, K, or alkylammonium), and decaborane.
专利号:US-5861532-A 优先权日:1997-03-04 标 题:Solid-phase synthesis of N-alkyl amides 发明人:BROWN EDWARD G; NUSS JOHN M 权利人:CHIRON CORP 摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.
专利号:US-2004138469-A1 优先权日:2002-12-23 标 题 :Process for the synthesis of torsemide, in particular of pure and stable form II 发明人:LUSSANA MASSIMILIANO; RAINONI MAURO; GAMBUZZA FILIPPO 权利人:COSMA S P A 摘要:The present invention relates to a new process for the synthesis of torsemide, in particular of pure and stable form II, which comprises direct synthesis of torsemide from 4-(3-methylphenylamino)-3-pyridine-sulphonamide. The new process envisages fewer steps than the processes described in the prior art, with improved yields and good quality from the chemical and preferably polymorphous points of view.
[参考文献]: A Starobrat, Et Al. Salts Of Highly Fluorinated Weakly Coordinating Anions As Versatile Precursors Towards Hydrogen Storage Materials. Dalton Trans. 2015 Dec 7;44(45):19469-77. [参考文献]: Bart Van Der Burg, Et Al. A High Throughput Screening System For Predicting Chemically-Induced Reproductive Organ Deformities. Reprod Toxicol. 2015 Aug 1:55:95-103. [参考文献]: Benjamin J Bergner, Et Al. Tempo: A Mobile Catalyst For Rechargeable Li-O Batteries. J Am Chem Soc. 2014 Oct 22;136(42):15054-64. [参考文献]: D Mata, Et Al. Diels-Alder Functionalized Carbon Nanotubes For Bone Tissue Engineering: In Vitro/in Vivo Biocompatibility And Biodegradability. Nanoscale. 2015;7(20):9238-51. [参考文献]: Erik N K Cressman, Et Al. Dual Mode Single Agent Thermochemical Ablation By Simultaneous Release Of Heat Energy And Acid: Hydrolysis Of Electrophiles. Int J Hyperthermia. 2013;29(1):71-8.
合成参考文献
摘要:Krueger, A., Science of Synthesis, (2008) 43, 534. 摘要:Ito, S.; Morita, N., Science of Synthesis, (2010) 45, 474. 摘要:Lin, W.-C.; Wu, Y.-T., Science of Synthesis, (2010) 45, 1037. 摘要:Shindo, M.; Yoshikawa, T.; Yaji, K., Science of Synthesis, (2009) 46, 364. 摘要:Ito, S.; Morita, N., Science of Synthesis, (2010) 45, 475.