CAS: 115262-01-6; (Bromodifluoromethyl)Trimethylsilane

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65864-64-4 151479-64-0

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CAS号65864-64-4 (二氟甲基)三甲基硅烷 | CAS号2857-97-8 三甲基溴硅烷 | CAS号75-61-6 二溴二氟烷 | CAS号81290-20-2 (三氟甲基)三甲基硅烷 | CAS号75-77-4 三甲基氯硅烷 | CAS号353-59-3 溴氯二氟甲烷 | CAS号24933-57-1 (二氟甲基)(4-硝基苯基)硫烷 | CAS号83882-67-1 1-(4-二氟甲氧基)苯基)乙酮 | CAS号73960-07-3 4-(二氟甲氧基)苯甲醛 | CAS号71653-64-0 2-(二氟甲氧基)苯甲醛 | CAS号65864-64-4 (二氟甲基)三甲基硅烷 | CAS号659-33-6 4-(二氟甲氧基)苯甲醇 | CAS号138101-00-5 (9CI)-(3,3-二氟-1... | CAS号138101-02-7 3,3-difluoro-1-... | CAS号1535-65-5 二氟甲基苯基砜 | CAS号22225-77-0 1-(二氟甲氧基)-2-硝基苯

(二氟甲基)三甲基硅烷置于硫酸,双氧水,Sodium Bromide体系中,用 水 用作溶剂,化学反应 1.0H,以80%的收率获得二氟溴甲基三甲基硅烷
参考文献:二氟(三甲基甲硅烷基)乙腈:合成和氟烷基化反应
标题:二氟(三甲基甲硅烷基)乙腈:合成和氟烷基化反应
摘要:通过将二氟卡宾插入甲硅烷基氰化物中,制备了一种新的硅试剂二氟(三甲基甲硅烷基)乙腈.所得的硅烷在碱性或酸性条件下可作为对醛,N-甲苯基亚胺,N-烷基亚胺和烯胺的非常好的氰基二氟甲基化试剂.
Doi:10.1021/jo301094B

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:WO-2025128873-A1
优先权日:2023-12-12
标题:Heterocyclic pyridinone compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

专利号:WO-2018232777-A1
优先权日:2017-06-19
标题 :Synthesis method for difluorodeuteromethoxy(thio) functional group-containing aromatic compound
发明人：WU YUSHENG; GENG YANG; ZOU DAPENG; LI JINGYA; NIU CHENGSHAN; ZHENG MAOLIN; LIANG APENG
权利人:TETRANOV PHARMACEUTICAL CO LTD
摘要:A method for synthesizing an aromatic compound containing a difluorodeuterated methoxy functional group or a difluorodeuterated methylthio functional group, wherein a difluorocarbene donor reacts with Ar-(XH)n and heavy water in the presence of a base, The deuterated product Ar-(XCF2D)n is obtained, and the difluorocarbene donor is BrCF2PO(OR)2 or (chlorodifluoromethyl)trimethylsilane or (bromodifluoromethyl)trimethylsilane. It is selected from the group consisting of Na, K, Li, Mg, Zn, Al, NaH, KH, LiH, LiAlH4, KOD, NaOD, NaOMe, NaOEt, NaOBu, sodium carbonate, potassium carbonate and cesium carbonate. Simple and gentle, high yield, high generation rate, easy to produce amplification and so on.

专利号:CN-107226769-A
优先权日:2017-06-19
标题:A kind of synthesis method of aromatic compound containing difluoro deuterated methoxy (sulfur) group functional group

专利号:CN-119080701-A
优先权日:2024-08-27
标 题 :Synthesis method of imidazole difluoromethylation reaction promoted by alkali

专利号:CN-117209381-A
优先权日:2022-06-10
标 题 :A kind of carboxylic acid compound containing carbocyclic and heterocyclic rings and its synthesis method