CAS: 117723-13-4; ((2R,3S,4R,5R)-5-(2-Amino-7-Methyl-6-Oxo-1,6,7,8-Tetrahydro-9H-Purin-9-yl)-3,4-Dihydroxytetrahydrofuran-2-yl)Methyl Trihydrogen Diphosphate

鸟苷酸置于2,2'-二硫二吡啶,N,N-二丁基丁烷-1-胺,磷酸,三苯基膦,Sodium Hydroxide体系中,用 水,N,N-二甲基甲酰胺 用作溶剂,化学反应生成7-甲基鸟苷二磷酸游离酸/钠盐/tea盐
参考文献:一种含六元糖环结构的起始加帽寡核苷酸引物及其制备方法和应用
标题:一种含六元糖环结构的起始加帽寡核苷酸引物及其制备方法和应用
摘要:本发明提供了一种含六元糖环结构的起始加帽寡核苷酸引物及其制备方法和应用,该含六元糖环结构的起始加帽寡核苷酸引物的分子式为m7Gpppa2'omepg,其中m7G为n7‑甲基化的鸟苷或任何鸟苷类似物,A为任何天然的,修饰的或非天然的腺苷或任何腺苷类似物.本发明提供的含六元糖环结构的起始加帽寡核苷酸引物合成的mrna具有更低的免疫原性和更高的蛋白翻译效率,更高的稳定性.

专利信息

专利号:US-2023130423-A1
优先权日:2020-02-12
标题:Novel mrna 5'-end cap analogs, rna molecule incorporating the same, uses thereof and method of synthesizing rna molecule or peptide
发明人：WARMINSKI MACIN; SIKORSKI PAWEL; KOWALSKA JOANNA; JEMIELITY JACEK
权利人:UNIV WARSZAWSKI; EXPLORNA THERAPEUTICS SP Z O O
摘要:The invention relates to new mRNA 5′ end cap analogs, RNA molecules containing them, their uses and methods for their in vitro synthesis, as well as a method for protein or peptide synthesis in vitro or in cell cultures, which method encompasses translation of the RNA molecule.

专利号:US-2023295215-A1
优先权日:2020-02-12
标 题 :Novel mrna 5'-end cap analogs modified within phosphate residues, rna molecule incorporating the same, uses thereof and method of synthesizing rna molecule or peptide
发明人：WARMINSKI MARCIN; SIKORSKI PAWEL; KOWALSKA JOANNA; JEMIELITY JACEK
权利人:UNIV WARSZAWSKI; EXPLORNA THERAPEUTICS SP Z O O
摘要:The invention relates to new 5′mRNA end cap analogs, RNA molecules containing them, their uses and methods for their in vitro synthesis, as well as a method for protein or peptide synthesis in vitro or in cell cultures, which method translates the RNA molecule.