1H-1,2,4-三唑,1-氯-2-(1-氯环丙基)-2-(2-氯苯基)丙醇-2-醇,2-(2-氯苄基)-2-(1-氯环丙基)环氧乙烷置于三乙烯二胺,Potassium Carbonate体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 3.0H,以73.3%的收率获得脱硫丙硫菌唑 参考文献: A Process For Preparation Of Fungicidally Active Triazole Compounds[fr] Procédé De Préparation De Composés De Triazole à Activité Fongicide 标题: A Process For Preparation Of Fungicidally Active Triazole Compounds[fr] Procédé De Préparation De Composés De Triazole à Activité Fongicide 摘要:本发明涉及一种制备具有杀菌活性的三唑化合物的过程,其中该过程使用同系笼胺作为催化剂.
专利号:US-11292775-B2 优先权日:2017-12-21 标 题 :Efficient process for the synthesis of 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione(prothioconazole) and its intermediates 发明人:KADAM SUBHASH RAJARAM; JANI NILESH; SHINDE RAVINDRA; SHAH KENAL V; SHAH BHAVESH V; GUJRAL AJIT SINGH; BYREGOWDA GANGANARASAIAH; SIVAIAH GANADI; PAWAR JIVAN DHANRAJ; PATI HARI NARAYAN 权利人:GSP Crop Science Pvt Ltd 摘要:The present invention relates to an improved and efficient process for the synthesis of 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, compound of formula (I) (Prothioconazole). The present invention more particularly relates to an improved process for manufacturing of 2-(1-chloro-cycloprop-1-yl)-3-(2-chloro phenyl)-2-hydroxy propyl-1-hydrazine (compound of formula III) and 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2,4-triazolidine-3-thione (compound of formula II) which are mainly used for synthesis of Prothioconazole which is knows as an active compound with microbicidal fungicidal properties.
专利号:CN-111527071-A 优先权日:2017-12-21 标题:For the synthesis of 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-tris Improved and efficient methods of oxazole-3-thione (prothioconazole) and intermediates thereof
专利号:US-2020369627-A1 优先权日:2017-12-21 标题 :Improved and efficient process for the synthesis of 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro-3h-1,2,4-triazole-3-thione(prothioconazole) and its intermediates
专利号:CN-113788797-A 优先权日:2021-10-12 标 题:A kind of desulfurized prothioconazole impurity and its synthesis method and application
专利号:CN-116655548-A 优先权日:2023-06-05 标题:Synthesis method of prothioconazole
[参考文献]: Iza Matarashvili, Et Al. High-Performance Liquid Chromatographic Separations Of Stereoisomers Of Chiral Basic Agrochemicals With Polysaccharide-Based Chiral Columns And Polar Organic Mobile Phases. J Sep Sci. 2015 Dec;38(24):4173-9.
合成参考文献
摘要:S60 | SWISSPEST19 | Swiss Pesticides and Metabolites from Kiefer et al 2019 | DOI:10.5281/zenodo.3544759 摘要:S78 | SLUPESTTPS | Pesticides and TPs from SLU, Sweden | DOI:10.5281/zenodo.4687924