CAS: 126784-99-4; (8S,11R,13S,14S,17R)-17-Acetyl-11-(4-(Dimethylamino)Phenyl)-13-Methyl-3-Oxo-2,3,6,7,8,11,12,13,14,15,16,17-Dodecahydro-1H-Cyclopenta[a]Phenanthren-17-Yl Acetate

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CAS号730962-28-4 3,3-ethylenedio... | CAS号108-24-7 乙酸酐 | CAS号159811-51-5 乌利司他 | CAS号96-63-9 Essigsaeure-tri... | CAS号126690-41-3 3,3,20,20-双(亚乙二... | CAS号91934-95-1 (5α,11β,17α)-11... | CAS号54201-84-2 醋酸优力司特中间体 | CAS号54201-83-1 3,3,20,20-Bis(e... | CAS号290825-36-4 3-ethylenedioxy...

3,3-Ethylenedioxy-5α-Hydroxy-17α-Acetoxy-11β-4-(N,,N-Dimethylaminophenyl)-19-Norpregna-9-En-20-One置于水,碘,溶剂黄146,1,2-二溴乙烷体系中,用 四氢呋喃 用作溶剂,化学反应 2.5H,以82%的收率获得醋酸乌利司他
参考文献: Method For Preparing 17 Alpha-Acetoxy-11Beta-(4-N,N-Dimethylaminophenyl)-19-Norpregna-4,9-Diene-3,20-Dione,Intermediates Thereof,And Methods For The Preparation Of Such Intermediates[fr] Procede De Preparation De 17 Dollar G(A)-Acetoxy-11 Dollar G(B)-(4-N,N-Dimethylaminophenyl)-19-Norpregna-4,9-Diene-3,20-Dione,D'Intermediaires De Ceux-Ci Et Procedes De Preparation Desdits Intermediaires
标题: Method For Preparing 17 Alpha-Acetoxy-11Beta-(4-N,N-Dimethylaminophenyl)-19-Norpregna-4,9-Diene-3,20-Dione,Intermediates Thereof,And Methods For The Preparation Of Such Intermediates[fr] Procede De Preparation De 17 Dollar G(A)-Acetoxy-11 Dollar G(B)-(4-N,N-Dimethylaminophenyl)-19-Norpregna-4,9-Diene-3,20-Dione,D'Intermediaires De Ceux-Ci Et Procedes De Preparation Desdits Intermediaires

专利信息

专利号:US-8110691-B2
优先权日:2006-06-14
标题 :Industrial process for the synthesis of 17α-acetoxy-11β-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione and new intermediates of the process
发明人：DANCSI LAJOSNE; VISKY GYOERGY; TUBA ZOLTAN; CSOERGEI JANOS; MOLNAR CSABA; MAGYARI ENDRENE
权利人:DANCSI LAJOSNE; VISKY GYOERGY; TUBA ZOLTAN; CSOERGEI JANOS; MOLNAR CSABA; MAGYARI ENDRENE; RICHTER GEDEON NYRT
摘要:A new industrial process for the synthesis of solvate-free 17α-acetoxy-11β-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB-2914] of formula (I) which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII) and (VIII) used as intermediates in the process.

专利号:US-9676814-B2
优先权日:2013-10-01
标题:Industrial process for the synthesis of ulipristal acetate and its 4′-acetyl analogue
发明人：Mahó Sándor; SÃ?NTA CSABA; Csörgei János; Horváth János; ARANYI ANTAL; BÉNI ZOLTÃ?N
权利人:RICHTER GEDEON NYRT
摘要:The present invention relates to a new process for the synthesis of compounds of formula (I) (wherein the meaning of R is dimethylamino or acetyl group) using the compound of formula (II) (wherein the meaning of R is dimethylamino or 2-methyl-1,3-dioxolan-2-yl group) as starting material, as well as to the intermediate of the process.

专利号:US-11993606-B2
优先权日:2015-10-16
标题:Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
发明人：MOHAMED MOHAMED-ESLAM F; OTHMAN AHMED A; PANGAN AILEEN L; SONG IN-HO; KLÃœNDER BEN; VOSS JEFFREY W; PADLEY ROBERT J; CAMP HEIDI S
权利人:ABBVIE INC
摘要:The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and various spondyloarthritic conditions, including types of axial spondyloarthritis (axSpA)), kits, methods of synthesis, and products-by-process. In various aspects, provided are methods for treating active non-radiographic axSpA (nr-axSpA) and methods for treating active ankylosing spondylitis (AS).

专利号:US-11976077-B2
优先权日:2015-10-16
标 题 :Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-α]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms therof
发明人：PANGAN AILEEN L; TEIXEIRA HENRIQUE D; MOHAMED MOHAMED-ESLAM F; OTHMAN AHMED A; KLÃœNDER BEN; VOSS JEFFREY W; PADLEY ROBERT J; CAMP HEIDI S
权利人:ABBVIE INC
摘要:The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.

专利号:US-11512092-B2
优先权日:2015-10-16
标题 :Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
发明人：ALLIAN AYMAN; JAYANTH JAYANTHY; MOHAMED MOHAMED-ESLAM F; MULHERN MATHEW; NORDSTROM FREDRIK LARS; OTHMAN AHMED A; ROZEMA MICHAEL J; BHAGAVATULA LAKSHMI; MARROUM PATRICK J; MAYER PETER T; SHEIKH AHMAD Y; BORCHARDT THOMAS B; KLÃœNDER BEN
权利人:ABBVIE INC
摘要:The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and various spondyloarthritic conditions, including types of axial spondyloarthritis (axSpA)), kits, methods of synthesis, and products-by-process. In various aspects, provided are methods for treating active non-radiographic axSpA (nr-axSpA) and methods for treating active ankylosing spondylitis (AS).

专利号:US-2009187032-A1
优先权日:2006-06-14
标 题 :INDUSTRIAL PROCESS FOR THE SYNTHESIS OF 17alpha-ACETOXY-11beta-[4-(N,N-DIMETHYL-AMINO)-PHENYL]-19-NORPREGNA-4,9-DIENE-3,20-DIONE AND NEW INTERMEDIATES OF THE PROCESS