CAS: 13670-99-0; 1-(2,6-Difluorophenyl)Ethanone

相似化合物

87327-65-9 51788-77-3 364-83-0

上下游产品

1,3-Difluorobenzene acetyl chloride 2,6 difluorobenzonitrile methyllithium 1-(2,6-difluoro-3-nitrophenyl)ethanone 2-bromo-1-(2,6-difluorophenyl)ethanone (S)-1-(2,6-difluorophenyl)ethanol [R]-1-(2,6-difluorophenyl)-1-ethanol

1,3-二氟苯置于正丁基锂,三氯化铝,四甲基乙二胺体系中,用 四氢呋喃,正己烷,二氯甲烷 用作溶剂,化学反应 21.0H,反应生成2,6-二氟苯乙酮
参考文献:苯并二官能化1,3-二取代
标题:苯并二官能化1,3-二取代
摘要:当经典方法(特别是涉及2位阴离子的方法)无效时,已研究了由对位基团对1,3-二取代的苯1,3-二取代基的2位官能化作用.因此,已经以非常好的收率制备了1,3-二卤代或1,3-二甲氧基苯的2-三甲基甲硅烷基衍生物.它们转化成相应的1,2,3-三取代的苯已经乙酰化,碘化作用或磺化被方便地进行,除了在1,3-Dimethoxylated化合物的磺化的情况下,其中本位甲硅烷基取代基的作用被甲氧基取代基的定向作用所超越.相反,在相同的底物上,使用氯磺酰基异氰酸酯成功地进行了位置2的氰化反应:据我们所知,该反应是芳族系列中三甲基甲硅烷基被氰基取代的第一个实例.
Doi:10.1016/s0040-4020(01)80238-6

专利信息

专利号:US-5059709-A
优先权日:1990-11-13
标题 :Process for the synthesis of α-[(dialkylamino)substituted-methylene]-β-oxo-(substituted)propanentriles
发明人：DUSZA JOHN P; CHURCH ROBERT F
权利人:AMERICAN CYANAMID CO
摘要:A novel process for producing α-[(dialkylamino) substituted-methylene]β-oxo-(substituted) propanenitriles of the formula: ##STR1## where R, R 1 and R 2 are defined in the specification by reacting a substituted isoxazole with a diaklylamide dimethylacetal is provided.

专利号:US-9328061-B2
优先权日:2012-03-01
标题:Simple organic molecules as catalysts for practical and efficient enantioselective synthesis of amines and alcohols
发明人：HOVEYDA AMIR H; SILVERIO DANIEL L; PILYUGINA TATIANA; TORKER SEBASTIAN; ROBBINS DANIEL
权利人:TRUSTEES BOSTON COLLEGE
摘要:The present invention provides organic molecules and methods thereof for reactions between organoboron reagents and double bonds, such as imines or carbonyls, to stereoselectively provide chiral products including amines and alcohols, entities useful for the preparation of biologically active molecules.

专利号:CN-111019915-A
优先权日:2019-11-08
标 题:Application of carbonyl reductase mutants in the synthesis of chiral ortho-halogenated-α-phenylethanol

专利号:US-2015057451-A1
优先权日:2012-03-01
标 题 :Simple organic molecules as catalysts for practical and efficient enantioselective synthesis of amines and alcohols

专利号:WO-2013131043-A1
优先权日:2012-03-01
标 题:Simple organic molecules as catalysts for practical and efficient enantioselective synthesis of amines and alcohols

专利号:CN-111019915-B
优先权日:2019-11-08
标题:Application of carbonyl reductase mutants in the synthesis of chiral ortho-halogenated-α-phenylethanol