CAS: 145783-14-8; 4,6-Dichloro-5-Nitro-2-(Propylthio)Pyrimidine

相似化合物

145783-15-9 1979-96-0 145783-14-8

上下游产品

CAS号145783-13-7 5-硝基-2-(丙基硫代)嘧啶... | CAS号121-69-7 N,N-二甲基苯胺 | CAS号145783-12-6 S-丙基-2-硫代巴比妥酸 | CAS号274693-27-5 替卡格雷 | CAS号145783-15-9 4,6-二氯 -2-(丙硫基)...

4,6-Dihydroxy-5-Amino-2-Propanethiopyrimidine置于三氯氧磷体系中,化学反应 10.0H,以93.8%的收率获得4,6-二氯-5-硝基-2-丙硫基嘧啶
参考文献:替格瑞洛中间体4,6-二氯-2-丙巯基-5-氨基嘧啶的制备方法
标题:替格瑞洛中间体4,6-二氯-2-丙巯基-5-氨基嘧啶的制备方法
摘要:本发明替格瑞洛中间体4,6-二氯-2-丙巯基-5-氨基嘧啶的制备方法属于药物制备领域,本发明4,6-二氯-2-丙巯基-5-氨基嘧啶的制备方法,包括以下反应步骤:以丙二酸二烷烃酯为原料,经过硝化,得到2-硝基丙二酸二烷烃酯,再与硫脲环合生成5-硝基-2-硫代巴比妥酸,再与卤代正丙烷进行硫代烷基化反应得到4,6-二羟基-5-硝基-2-丙巯基嘧啶,再在催化氢化下得到4,6-二羟基-5-氨基-2-丙巯基嘧啶,最后与三氯氧磷经氯代反应得到目标化合物4,6-二氯-5-氨基-2-丙巯基嘧啶.本发明的方法具有反应步骤少,反应条件温和,易于工业化的特点.

专利信息

专利号:US-9469614-B2
优先权日:2011-10-27
标 题:Synthesis of triazolopyrimidine compounds
发明人：ZUPANCIC BORUT; MARAS NENAD; STERK DAMJAN
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives.

专利号:EP-2607355-A1
优先权日:2011-12-23
标 题:Synthesis of triazolopyrimidine compounds
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.

专利号:US-9278972-B2
优先权日:2011-12-23
标题 :Synthesis of triazolopyrimidine compounds
发明人：MARAS NENAD; GAZIC SMILOVIC IVANA; STERK DAMJAN
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.

专利号:US-9221829-B2
优先权日:2011-09-14
标题:Synthesis of triazolopyrimidine compounds
发明人：MARAS NENED; ZUPANCIC BORUT
权利人:MARAS NENED; ZUPANCIC BORUT; LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives, suitable for the preparation of Ticagrelor (TCG).

专利号:EP-2570405-A1
优先权日:2011-09-14
标题:Synthesis of Triazolopyrimidine Compounds
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the filed of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives, suitable for the preparation of ticagrelor (TGC)

专利号:EP-2586773-A1
优先权日:2011-10-27
标题 :Synthesis of Triazolopyrimidine Compounds
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives.