CAS: 168267-41-2; (3,4-Difluorophenyl)Boronic Acid

相似化合物

754226-39-6 1033592-49-2 143418-49-9

上下游产品

CAS号90897-92-0 3,4-二氟苯基溴化镁 | CAS号85312-59-0 3,4-二氟-4'-(反式-4... | CAS号134412-17-2 3,4-二氟-4'-(反式-4... | CAS号742058-85-1 2-(3,4-difluoro... | CAS号866108-76-1 3-联苯-3,4-二氟-乙酸 | CAS号89931-90-8 3-(3,4-difluoro...

Magnesium,1,2-Difluorobenzene-5-Ide,Bromide置于硼酸三异丙酯体系中,用 四氢呋喃 用作溶剂,以41%的收率获得3,4-二氟苯硼酸
参考文献:3α-(取代的苯基)降冰片烷2β-羧酸甲酯的合成及其单胺转运蛋白的结合性能.去甲肾上腺素转运蛋白选择性化合物.
标题:3α-(取代的苯基)降冰片烷2β-羧酸甲酯的合成及其单胺转运蛋白的结合性能.去甲肾上腺素转运蛋白选择性化合物.
摘要:3α-(取代的苯基)降冰片烷2β-羧酸甲酯(8A-H)对去甲肾上腺素转运蛋白(net)有很高的亲和力.最有效和选择性最大的化合物是3Alpha-(3-氟-4-甲基苯基)降冰片烷2β-羧酸甲酯(8D),在net处的ki值为0.43 Nm,相对于结合的选择性为21倍和55倍多巴胺和5-羟色胺转运蛋白.8D的发展使具有相同结构类别的所有三种转运蛋白具有选择性的可用化合物.
Doi:10.1021/jm058164J

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-12428425-B2
优先权日:2020-05-04
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：CZABANIUK LARA C; HOPPER TIMOTHY; HOUZE JONATHAN B; PANTELEEV JANE; RESCOURIO GWENAELLA; SANTORA VINCENT; WANG HAOXUAN; WHITE RYAN D; WONG ALICE R; WU YONGWEI; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN
权利人:AMGEN INC; VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-6121448-A
优先权日:1995-03-28
标题 :Pyrimidine compounds
发明人：LEWIS ROBERT ANDREWS; GOODBY JOHN WILLIAM; TOYNE KENNETH JOHNSON; HIRD MICHAEL
权利人:SECR DEFENCE BRIT
摘要:The synthesis of novel compound (I) is described: 5-bromo-2-iodopyrimidine may be used for the synthesis of a range of chemical compounds both known and novel. The synthesis of a number of novel liquid crystalline compounds is described.

专利号:UA-122133-C2
优先权日:2014-11-19
标题 :METHOD OF SYNTHESIS OF BENZAZEPINE DERIVATIVES

专利号:WO-2006079916-A1
优先权日:2005-01-26
标 题 :Thieno [2,3-d] pyrimidine compounds as inhibitors of adp-mediated platelets aggregation
发明人：ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; RAHMAN HAYAT; SCHWEITZER BARBARA ANN; TENBRINK RUTH ELIZABETH
权利人:PHARMACIA & UPJOHN CO LLC; ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; RAHMAN HAYAT; SCHWEITZER BARBARA ANN; TENBRINK RUTH ELIZABETH
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I): wherein A1, A2, A3, A4, A5, A6, A7, A8, X4, X6, R2, R4, R5, and R6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:JP-2010222357-A
优先权日:2002-03-11
标题 :Intermediate compounds for the synthesis of aminoindazole derivatives