CAS: 23326-27-4; Methyl But-2-Ynoate

该化合物是二丁基酸的甲基酯,其特点是其乙酰功能和酯类,该化合物通常用作有机合成的多用途构件,特别是用于制备药品,农用化学品和特殊化学品,其反应性三联保证能够参与点击化学,循环添加和其他组合反应,提供合成灵活性;酯能提高有机溶剂溶解性,便利实验室和工业环境中的处理;甲基二丁酸因其在标准条件下的稳定性及其在将丙烯或丁诺酸植物引入目标分子方面的作用而得到重视;建议在惰性条件下妥善储存以保持纯度.

结构式图片

相似化合物

590-93-2 764-01-2 922-67-8

欧盟法规

ECHA物质C&L通报

上下游产品

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合成工艺路线路线简述

  • 合成目标产物 Methyl 2-Butynoate 主要起始原料 Butanoic Acid, 3-Oxo-2-(Triphenylphosphoranylidene)-, Methyl Ester
  • (文献来源)合成步骤主要原料 Butanoic Acid, 3-Oxo-2-(Triphenylphosphoranylidene)-, Methyl Ester
[acetyl(Methoxycarbonyl)Methylene]Triphenylphosphorane 以71%的收率获得2-丁炔酸甲酯
参考文献:Synthesis And Spectroscopic Characterization Of 1-13C-And 4-13C-Plastoquinone-9
标题:Synthesis And Spectroscopic Characterization Of 1-13C-And 4-13C-Plastoquinone-9
摘要:
Doi:10.1002/1099-0690(200207)2002:13<2094::Aid-Ejoc2094>3.0.Co;2-E

海关参考信息

专利信息


专利号:US-8153839-B2
优先权日:2005-09-14
标题:Method for synthesis of keto acids or amino acids by hydration of acetylene compound
发明人:OGO SEIJI; FUKUZUMI SHUN-ICHI
权利人:OGO SEIJI; FUKUZUMI SHUN-ICHI; JAPAN SCIENCE & TECH AGENCY
摘要:An object of the present invention is to provide a method for synthesis of keto acids by hydration of an acetylene compound (acetylene-carboxylic acids) under mild conditions free from harmful mercury catalysts and a method for synthesis of amino acids from acetylene-carboxylic acids in a single container (one-pot or tandem synthesis). In one embodiment of the method according to the present invention for synthesis of keto acids, acetylene-carboxylic acids is hydrated in the presence of a metal salt represented by General Formula (1), n nwhere M 1 represents an element in Group VIII, IX, or X of the periodic table, and X 1 , X 2 , or X 3 ligand represents halogen, H 2 O, or a solvent molecule, and k represents a valence of a cation species, and Y represents an anion species, and L represents a valence of the anion species, and each of K and L independently represents 1 or 2, and k×m=L×n.

专利号:US-3872101-A
优先权日:1969-04-11
标题:Synthesis of {60 , {62 -unsaturated compounds
发明人:SIDDALL JOHN E; FRIED JOHN H
权利人:ZOECON CORP
摘要:Stereospecific synthesis of Alpha , Beta -ethylenically unsaturated compounds by the reaction of an organo-copper or organo-manganese reagent with an Alpha , Beta -acetylenically unsaturated compound at a temperature of -40*C or less.

专利号:US-8796454-B2
优先权日:2012-05-04
标 题 :Synthesis of [2.2.2]-diazabicyclic ring systems
发明人:SCHEERER JONATHAN R
权利人:COLLEGE WILLIAM & MARY
摘要:Herein we describe compositions and methods for the synthesis of [2.2.2]-diazabicyclic structures comprising a domino reaction sequence involving aldol condensation, alkene isomerization, and intramolecular hetero-Diels-Alder cycloaddition. Excellent diastereofacial control during the cycloaddition is enforced with a removable chiral phenyl aminal diketopiperazine substituent. The reaction sequence rapidly generates molecular complexity and is competent with both enolizable and non-enolizable aldehyde substrates. This method provides an efficient route to [2.2.2]-diazabicyclic structures, common to bioactive prenylated indole alkaloids such as the brevianamides and stephacidins.

专利号:US-8268936-B2
优先权日:2005-01-04
标题:Synthesis of hybrid block copolymers and uses thereof
发明人:BREITENKAMP KURT; SILL KEVIN N
权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC
摘要:The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and methods of preparing the same.

专利号:US-2012196989-A1
优先权日:2005-02-11
标题:Synthesis of homopolymers and block copolymers
发明人:BREITENKAMP KURT; SILL KEVIN N
权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC
摘要:The present invention relates to the field of polymer chemistry and more particularly to homopolymers and block copolymers and methods of preparing the same.

专利号:US-2024417420-A1
优先权日:2021-10-04
标题:Polar cd33 ligands suitable for incorporation into carriers
发明人:MAGNANI JOHN L; PETERSON JOHN M; GHOSH LNDRANATH; NOGUEIRA JASON; RAHMAN MITI
权利人:GLYCOMIMETICS INC
摘要:CD33 ligands which are useful for the synthesis of CD33 ligand-bearing carriers, wherein said CD33 ligand-bearing carriers are directly or indirectly linked to or associated with at least one anti-cancer agent, are described herein. Uses of said CD33 ligand-bearing carriers for treating and/or preventing a disease, disorder, or condition such as acute myeloid leukemia (AML) are also described.
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主要参考文献

参考标题:Regioselective Synthesis Of 2,3,4-Trisubstituted Pyrroles Via Pd(II)-Catalyzed Three-Component Cascade Reactions Of Amines, Alkyne Esters, And Alkenes
作者:Xu Zhang,Xuefeng Xu,Gong Chen,Wei Yi |发布日期:2016.10.7
摘要:Three-Component Cascade Reaction Of Diverse Amines, Alkyne Esters, And Alkenes Is Disclosed For The Direct Synthesis Of Diverse 2,3,4-Trisubstituted Pyrroles With Broad Functional Group Tolerance And In Good To Excellent Yields. This Transformation Is Supposed To Proceed Through The Cascade Formation Of C(Sp2)-C(Sp2) And C(Sp2)-N Bonds Via Pd(II)-Catalyzed Regioselective Alkene Migratory Insertion, Intramolecular

合成参考文献


摘要:Gandon, V.; Malacria, M., Science of Synthesis, (2008) 44, 221.
摘要:Burmester, C.; Haß, O.; Faust, R., Science of Synthesis, (2008) 43, 274.
摘要:Aguilar, E.; López, L. A., Science of Synthesis Knowledge Updates, (2014) 2, 101.
摘要:Aguilar, E.; López, L. A., Science of Synthesis Knowledge Updates, (2014) 2, 17.
摘要:Celik, I.; Hummel, S.; Kirsch, S. F., Science of Synthesis Knowledge Updates, (2019) 1, 36.
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