CAS: 39856-50-3; 5-Bromo-2-Nitropyridine

上下游产品

CAS号1072-97-5 2-氨基-5-溴吡啶 | CAS号2402-97-3 3-溴吡啶-N-氧化物 | CAS号504-29-0 2-氨基吡啶 | CAS号626-55-1 3-溴吡啶 | CAS号937623-38-6 5-(吡咯-1-基)吡啶-2-... | CAS号870521-31-6 2-异丙氧基-5-溴吡啶 | CAS号850142-79-9 5-溴-2-丙氧基吡啶 | CAS号83664-33-9 2-苄氧基-5-溴吡啶 | CAS号766-11-0 5-溴-2-氟吡啶 | CAS号55849-30-4 5-溴-2-乙氧基吡啶 | CAS号571189-16-7 4-(6-硝基-3-吡啶基)-... | CAS号571188-59-5 4-(6-氨基吡啶-3-基)哌... | CAS号571189-49-6 1-甲基-4-(6-氨基吡啶-... | CAS号1072-97-5 2-氨基-5-溴吡啶

2-氨基吡啶置于n-溴代丁二酰亚胺(Nbs),硫酸,双氧水体系中,用 水,乙腈 作为反应溶剂,化学反应生成 5-溴-2-硝基吡啶
参考文献:大规模处理过氧化氢:5-溴-2-硝基吡啶的合成
标题:大规模处理过氧化氢:5-溴-2-硝基吡啶的合成
摘要:由相应的胺经过氧化氢氧化大规模制备5-溴-2-硝基吡啶.这种转化最初显示出低转化率,高杂质含量以及在实验室试验中缺乏可重复性.在工艺开发的同时,进行了安全性研究,以通过反应和绝热量热法研究氧化剂混合物的稳定性,组成和氧化反应本身.由此产生的稳健的反应条件和适当的安全范围允许开发出可重现,安全的方案,以大规模实施该化学方法,从而在整个试验过程中获得一致的结果.
DOI:10.1021/acs.Oprd.6B00433

专利信息

专利号:US-7781583-B2
优先权日:2006-09-08
标题:Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d] pryimidin-7-ones
发明人：ERDMAN DAVID THOMAS; FLAMME CATHLIN MARIE; NELSON JADE DOUGLAS
权利人:PFIZER
摘要:The present invention provides methods of preparing substituted 2-(pyridin-2-ylamino)-pirido[2,3-d]pyrimidin-7-ones (formula 1), n nuseful in treating cell proliferative disorders, or a pharmaceutically acceptable salt thereof.

专利号:US-9919064-B2
优先权日:2012-08-10
标 题 :Compositions, methods, and systems for the synthesis and use of imaging agents
发明人：CESATI RICHARD R; RADEKE HEIKE S; PANDEY SURESH K; PUROHIT AJAY; ROBINSON SIMON P
权利人:LANTHEUS MEDICAL IMAGING INC
摘要:The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

专利号:US-8926801-B2
优先权日:2009-01-16
标题 :Methods of electrospray chemical synthesis and device for use therein
发明人：REHMAN ATIQ
权利人:REHMAN ATIQ; CANAM BIORES INC
摘要:The present invention relates to methods of production of chemical bonds and subsequent molecules by electrospray ionization and the design of an electrospray chemical synthesizer, for use in chemical synthesis and expedited organic chemical reactions.

专利号:US-7405310-B2
优先权日:2001-03-05
标 题:Non-nucleoside reverse transcriptase inhibitors
发明人：LINDSTROM STEFAN; SAHLBERG CHRISTER; WALLBERG HANS; KALYANOV GENAIDY; ODEN LOURDES SALVADOR; NAESLUND LOTTA
权利人:MEDIVIR AB
摘要:This invention relates to non-nucleoside reverse transcriptase inhibitors active against HIV-1 and having an improved resistance and pharmacokinetic profile. The invention further relates to novel intermediates in the synthesis of such compounds and the use of the compounds in antiviral methods and compositions.

专利号:AU-2007297286-A1
优先权日:2006-09-08
标题 :Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones

专利号:US-2008125588-A1
优先权日:2006-09-08
标 题:SYNTHESIS OF 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3-d] PRYIMIDIN-7-ONES