CAS: 42564-51-2; 4-Fluoro-3-Nitrobenzaldehyde

上下游产品

4-fluorobenzaldehyde p-(2,2-Dichlor°Cyclopropyl)fluorobenzene (4-fluoro-3-nitrophenyl)methanol 4-chloro-3-nitro-benzaldehyde N-(4-formyl-2-nitro-phenyl)-glycineN-(4-formyl-2-nitro-phenyl)-glycine Nα-bis-(4-formyl-2-nitro-phenyl)-L-histidine1,Nα-bis-(4-formyl-2-nitro-phenyl)-L-histidine 4-fluoro-3-nitro-benzaldehyde dimethyl acetal 4-fluoro-3-nitrobenzylidenemalononitrile

4-氟-3-硝基苄醇置于戴斯-马丁氧化剂体系中,用 二氯甲烷 作为反应溶剂,化学反应 4.0H,以75%的收率获得产物4-氟-3-硝基苯甲醛
参考文献: Pyrimidine Fgfr4 Inhibitors[fr] Inhibiteurs De Fgfr4 Pyrimidine
标题: Pyrimidine Fgfr4 Inhibitors[fr] Inhibiteurs De Fgfr4 Pyrimidine
摘要:本文提供了作为fgfr4抑制剂有用的i式化合物,以及其使用方法.

专利信息

专利号:US-11512303-B2
优先权日:2017-05-27
标 题 :Engineered polypeptides and their applications in the synthesis of beta-hydroxy-alpha-amino acids
发明人：CHEN HAIBIN; BONG YONG KOY; XU QING; ZHOU AMENG; SHEN TIANRAN; YANG JIADONG; YANG ZHUHONG
权利人:ENZYMASTER NINGBO BIO ENG CO LTD
摘要:The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. The engineered polypeptides disclosed in this invention were developed through directed evolution based on the ability of catalytic synthesis of (2S, 3R)-2-amino-3-hydroxy-3-(4-nitrophenyl) propanoic acid. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing β-hydroxy-α-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of β-hydroxy-α-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.

专利号:US-11274287-B2
优先权日:2017-05-27
标 题 :Engineered aldolase polypeptides and uses thereof
发明人：CHEN HAIBIN; BONG YONG KOY; CAI BAOQIN; XU QING; SHEN TIANRAN; ZHOU AMENG; YANG JIADONG; YANG ZHUHONG; JI YAOYAO; ZHANG YINGXIN
权利人:ENZYMASTER NINGBO BIO ENG CO LTD
摘要:The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing β-hydroxy-α-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of β-hydroxy-α-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.

专利号:US-2021284987-A1
优先权日:2017-05-27
标 题:Engineered polypeptides and their applications in the synthesis of beta-hydroxy-alpha-amino acids

专利号:EP-3630798-B1
优先权日:2017-05-27
标 题:Engineered aldolase polypeptides and their applications in synthesis of beta-hydroxy-alpha-amino acids

专利号:CN-110869383-B
优先权日:2017-05-27
标题:Engineered polypeptides and their application in the synthesis of β-hydroxy-α-amino acids

专利号:WO-2018219107-A1
优先权日:2017-05-27
标题:Engineered polypeptides and their applications in synthesis of beta-hydroxy-alpha-amino acids