CAS: 523-80-8; 5-Allyl-4,7-Dimethoxybenzo[d][1,3]Dioxole

该化合物是一种自然产生的有机化合物,被归类为苯丙胺丙胺,主要见于某些基本油类,特别是阿皮亚塞家族植物的油类,如鹦鹉和.甲醇具有芳香特性,有助于这些植物独特的气味.化学上,它是苯丙酸化合物的甲氧代衍生物,其结构包括一个甲基氧基组和一个丙酰子链.甲醇展示了各种生物活动,包括抗微生物和抗氧化剂特性,这些特性引起了对食品和药物应用的兴趣.然而,重要的是要注意甲醇具有高浓度的毒性,应谨慎使用.从物理特性来看,甲醇通常不染色,而具有典型的黄色液体.其溶解性主要在有机溶剂中,而且水中的溶性也有限.

结构式图片

上下游产品

6-allyl-2,3-methylenedioxyphenol 1-methyl-4-nitrosobenzene 1,4-dimethoxy-2,3-methylenedioxybenzene allyl tosylate 4,7-dimethoxy-benzo[1,3]dioxole-5-carbaldehyde apional azoxybenzene isoapiol

合成工艺路线路线简述

    6-Allyl-2,3-Methylenedioxyphenol置于sodium Hydroxide,Dipotassium Peroxodisulfate体系中,化学反应生成 洋芹脑
    参考文献:303. 1:2:3:4-四羟基苯的衍生物.第五部分:香菜apiole及其衍生物的合成
    标题:303. 1:2:3:4-四羟基苯的衍生物.第五部分:香菜apiole及其衍生物的合成
    摘要:
    DOI:10.1039/jr9380001602

    海关参考信息

    专利信息


    专利号:WO-2024130393-A1
    优先权日:2022-12-21
    标 题 :Nanoparticle and method of synthesis thereof
    发明人:MOSKOVCHENKO SVITLANA
    权利人:MOSKOVCHENKO SVITLANA
    摘要:The present technology relates to nanoparticles, compositions comprising said nanoparticles, and methods of synthesis of said nanoparticles; wherein the nanoparticles comprise a metal nanoparticle core, a first coating of amphiphilic molecules, and a second coating of essential oil, essential oil primary constituent, or both, which combine the antimicrobial properties of metal nanoparticles, amphiphilic molecules, and essential oil or essential oil primary constituents.

    专利号:US-2014357576-A1
    优先权日:2013-05-31
    标题:Methods for enhancement of muscle protein synthesis
    发明人:BREUILLE DENIS; STELLINGWERFF TRENT; MOORE DANIEL RYAN; OFFORD CAVIN ELIZABETH ANN; PHILLIPS STUART MARTIN
    权利人:NESTEC SA
    摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis by enhancing myofibrillar muscle protein synthesis. The method includes administering to the individual a mixed macronutrient composition having (i) an amount of whey protein that is not capable of enhancing myofibrillar protein synthesis when ingested by itself and (ii) free leucine. The composition comprises at least about 5.0 g total leucine per dose.

    专利号:US-2014294788-A1
    优先权日:2013-03-26
    标 题 :Methods for enhancing muscle protein synthesis following concurrent training
    发明人:BAILEY DAVID MARK; ZALTAS ERIC SCOTT; MOORE DANIEL RYAN; STELLINGWERFF TRENT
    权利人:NESTEC SA
    摘要:The present disclosure provides methods for enhancing muscle protein synthesis following physical exertion. In a general embodiment, a method for enhancing muscle protein synthesis following physical exertion is provided and includes administering to an individual a composition comprising from about 15 to about 35 g protein immediately following concurrent training. Programs for enhancing muscle adaptation resulting from concurrent training are also provided. The programs include providing a composition comprising from about 15 to about 35 g protein; and providing guidelines for consumption including a recommendation of the amount of the composition to consume immediately following concurrent training.

    专利号:US-4803290-A
    优先权日:1987-05-29
    标 题 :Nonanol/nonene antimicrobial compositions
    发明人:BURKE BASIL A; NAIR MURALEEDHARAN
    权利人:PCRI INC
    摘要:Substituted 5'-nonanol/5'-nonene compounds which exhibit important antimicrobial and antifungal activity, compositions and methods of delivery against pathovars and pathogens, and methods of synthesis from commonly available reactants. The antimicrobial composition active ingredient is one or more substituted 1,2-alkylidenedioxybenzene compounds of the formula: where R3 is selected from 5'-nonanol and 5'-nonene, and R1 and R2 are selected from H and C1-C5 alkyl, alkenyl and alkynyl groups. The preferred compounds are 5-(5'-hydroxy- 5'- nonanyl)-1,1-methylenedioxybenzene and 4-(5'-non-4'-enyl)-1,2-methylenedioxybenzene. Compositions including these compounds exhibit antimicrobial activity against a variety of pathogens and pathovars, e.g., Xanthomonas campestris spp. bacteria, antifungal activity against a variety of fungi and bacteria, and are highly specific, e.g., having antifungal activity against wheat powdery mildew and cucumber downy mildew, but do not affect seed germination or have appreciable herbicidal or insecticidal activity. Methods and compositions for delivery of these agents against such pathogens, and methods of chemical synthesis of the compounds are disclosed.

    专利号:US-4876277-A
    优先权日:1987-05-29
    标题:Antimicrobial/antifungal compositions
    发明人:BURKE BASIL A; NAIR MURALEEDHARAN G
    权利人:PLANT CELL RES INST
    摘要:Substituted olefinic (allyl) benzene compounds which exhibit important antimicrobial (antibacterial and antifungal) activity, compositions and methods of delivery against pathovars and pathogens, and methods of synthesis from commonly available reactants. The antifungal composition active ingredient is one or more 4,5-substituted 2,3-alkylidenedioxy-1-olefinic benzenes of the formula: Formula I where R1 and R2 may be the same or different, and are selected from OH, and C1-C5 alkoxy (-OR) or thioalkyl (-SR) groups. R3 and R4 are selected from H and C1-C5 alkyl, alkenyl and alkynyl groups, and R5 is selected from C3-C7 alkyl, alkenyl and alkynyl groups. The preferred compounds are 4,5-substituted-2,3-methylenedioxy-1-allyl benzenes. Where R1=OCH3, R2=OH, R3 and R4=H and R5=allyl (2',3' propenyl) the compound may be called nor methyl-pseudo-dillapiole. Where R1=R2=OCH3, R3 and R4 are again H, and R5=allyl, the compound may be called pseudo-dillapiole. Compositions including these compounds exhibit antimicrobial activity against a variety of pathogens and pathovars, e.g., Xanthomonas campestris spp. bacteria, antifungal activity against a variety of fungi and bacteria, and are highly specific, e.g., antifungal activity against wheat powdery mildew, but do not affect seed germination or have herbicidal or insecticial activity. Methods and compositions for delivery of these agents against such pathogens, and methods of chemical synthesis of the compounds are disclosed.
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    主要参考文献


    1: Alajlouni AM, Al-Malahmeh AJ, Wesseling S, Kalli M, Vervoort J, Rietjens IMCM. Risk assessment of combined exposure to alkenylbenzenes through consumption of plant food supplements containing parsley and dill. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2017 Dec;34(12):2201-2211. doi: 10.1080/19440049.2017.1338837. Epub 2017 Jun 28. doi: 10.1016/j.fct.2016.01.018. Epub 2016 Jan 27. Review. doi: 10.4103/0973-1482.106529. doi: 10.1021/jf201945y. Epub 2011 Jun 30. German.

    合成参考文献


    摘要:Schafer, E. W., Jr., W. A. Bowles Jr., and J. Hurlbut. 1983. The acute oral toxicity and repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Archives of Environmental Contamination and Toxicology 12:355-382.
    摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 2004. Toxicity, Repellency of Phytotoxicity of 979 Chemicals to Birds, Mammals and Plants. Research Report No. 04-01. National Wildlife Research Center, Fort Collins, Colorado. 118 pp.
    摘要:LACOMME M, LE LORIER G, BARRIER J. [Acute intermittent porphyria and apiol absorption]. Bull Fed Soc Gynecol Obstet Lang Fr. 1954;6(3):278–81.
    参考文献:10.1021/acs.jnatprod.8b00878
    摘要:Samet AV, Shevchenko OG, Rusak VV, Chartov EM, Myshlyavtsev AB, Rusanov DA, Semenova MN, Semenov VV. Antioxidant Activity of Natural Allylpolyalkoxybenzene Plant Essential Oil Constituents. J Nat Prod. 2019 Jun 28;82(6):1451–8. doi: 10.1021/acs.jnatprod.8b00878.
    参考文献:10.1007/s11356-022-19733-7
    摘要:Rauf A, Akram M, Anwar H, Daniyal M, Munir N, Bawazeer S, Bawazeer S, Rebezov M, Bouyahya A, Shariati MA, Thiruvengadam M, Sarsembenova O, Mabkhot YN, Islam MN, Emran TB, Hodak S, Zengin G, Khan H. Therapeutic potential of herbal medicine for the management of hyperlipidemia: latest updates. Environmental Science and Pollution Research. 2022 Mar 22;29(27):40281–301. doi: 10.1007/s11356-022-19733-7.
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