专利号:US-2025215464-A1 优先权日:2022-07-08 标题 :Engineered enzyme for preparing a hydroxylated indanone intermediate useful in the synthesis of belzutifan 发明人:CHEUNG-LEE WAI LING; DIROCCO DANIEL A; GIL AGNIESZKA; HIRAGA KAORI; KIM JUNGCHUL; KOLEV JOSHUA; KOSJEK BIRGIT; MALONEY KEVIN M; SALEHI MARZIJARANI NASTARAN; MCINTOSH JOHN; MCMULLEN JONATHAN P; MOORE JEFFREY C; MURPHY GRANT S; PAN WEILAN; VELASQUEZ VELEZ JUAN E; VERMA DEEPTAK; WINSTON MATTHEW S; XIAO LI; ZHANG VICTORIA 权利人:MERCK SHARP & DOHME LLC 摘要:The present disclosure provides enzymes derived from the fungi Fusarium oxysporum c8D (“FoPip4H enzymesâ€?) having improved properties as compared to a naturally occurring wild-type enzyme including the capability of hydroxylating certain substituted indanones to provide optically pure 3-hydroxyindanones. Also provided are polynucleotides encoding the FoPip4H enzymes, host cells capable of expressing the FoPip4H enzymes, and processes for using the FoPip4H enzymes to synthesize (R)-4-fluoro-3-hydroxy-7-(methylsulfonyl)-2, 3-dihydro-1H-inden-1-one, a useful intermediate in the synthesis of belzutifan.
专利号:US-10882813-B2 优先权日:2014-12-17 标 题:Method for the synthesis of ferric oraganic compounds 发明人:PULLAGURLA MANIK REDDY; NANDA KUMAR MECHERIL VALSAN; RANGISETTY JAGADEESH BABU; BHUDETI RAJESH; NAGARAPU RADHA 权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD 摘要:The present invention relates to an improved method for the synthesis of Ferric Citrate and also to provide an amorphous form of Ferric Citrate having an active surface area less than 14 sq.m/g.
专利号:US-4592814-A 优先权日:1983-05-23 标题:Electrochemical synthesis of humic acid and other partially oxidized carbonaceous materials 发明人:VAUGHAN RONALD J; BY BANK OF AMERICA NT SA ADMIN 权利人:CHEVRON RES 摘要:A continuous cyclic electrolytic/carbon oxidation process wherein ferrous ion is oxidized at the anode and hydrogen is generated at the cathode of an electrolytic cell. The ferric ions produced at the anode are thereafter reduced to ferrous ions by contact with a solid carbonaceous material and the ferrous ions recycled for electrochemical reoxidation. The process produces partially oxidized organic products from the combustion process in high yield.
专利号:US-4254091-A 优先权日:1977-05-13 标题 :Diamond synthesis 发明人:WOERMANN EDUARD; KNECHT BARBARA; ROSHENHAUER MATTHIAS 权利人:WOERMANN EDUARD; KNECHT BARBARA; ROSHENHAUER MATTHIAS 摘要:The synthesis of diamonds from salts of iron, manganese, calcium and magnesium is disclosed. Specifically, such synthesis, in a closed system, has involved carbonate and oxylate salts of the indicated metals. The reaction occurs at temperatures between 550° and 1600° C., higher temperatures requiring higher reaction pressures; specifically, the production of synthetic diamonds from ferrous carbonate is disclosed. The ferrous carbonate was packed into a platinum capsule which was sealed gas-tight, packed in unfired pyrophyllite, and heated for two hours at 900° C. while in a solid media press which applied a pressure of 40 kb (subsequently defined).
专利号:US-9174846-B2 优先权日:2009-09-18 标题 :Ferric phosphate and methods of preparation thereof 发明人:BECK LARRY W; SOLTANI MAHROKH; WANG LIYA 权利人:BECK LARRY W; SOLTANI MAHROKH; WANG LIYA; A123 SYSTEMS LLC 摘要:High-purity crystalline ferric phosphate material with desirable characteristics for use in synthesis of nano-sized LFP cathode material are described. The ferric phosphate dihydrate material has as disclosed herein has a molar ratio of phosphorous to iron is from about 1.001 to about 1.05, a surface area of from about 25 m 2 /g to about 65 m 2 /g, and is substantially free of metallic or magnetic impurities. Methods of synthesizing high-purity crystalline ferric phosphate material with desirable characteristics for use in synthesis of nano-sized LFP cathode material are also described. In some embodiments, one or more magnetic traps are used during the reaction process and/or after the formation of the final product to remove magnetic impurities. In some embodiments, a synthetic method of ferric phosphate using multiple steps is described, wherein the intermediate of the synthesis is isolated and purified to improve the purity of the ferric phosphate material. In some embodiments, an iron compound is added to an aqueous solution of phosphoric acid. The solution pH and temperature are controlled to ensure the complete dissolution of the iron compound. The desired iron phosphate crystalline material can be obtained with high purity and high crystalline phase purity by controlling the pH and temperature of the solution.
专利号:US-10961631-B2 优先权日:2016-04-29 标 题:Microwave assisted synthesis of metal oxyhydroxides 发明人:LEONARD KEVIN C; BARFOROUSH JOSEPH M; SEUFERLING TESS E; SONG KELLY R 权利人:UNIV KANSAS 摘要:A method for making a metal oxyhydroxide electrocatalytic material comprises titrating a precursor solution with a (bi)carbonate salt, the precursor solution comprising a first metal salt and a solvent, wherein the titration induces reactions between the (bi)carbonate salt and the first metal salt to provide first metal carbonate species in the titrated precursor solution; and exposing the titrated precursor solution to microwave radiation to decompose the first metal carbonate species to form the metal oxyhydroxide electrocatalytic material and carbon dioxide. Mixed metal oxyhydroxide electrocatalytic materials such as nickel-iron oxyhydroxide may be formed. Also provided are the materials themselves, electrocatalytic systems comprising the materials, and methods of using the materials and systems.
摘要:USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present 摘要:21 CFR 184.1307b; U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Available from, as of November 1, 2004: 摘要: 摘要:American Conference of Governmental Industrial Hygienists. Documentation of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, 1986., p. 328 摘要:American Conference of Governmental Industrial Hygienists TLVs and BEIs. Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. Cincinnati, OH, 2008, p. 35