专利号:US-8367841-B2 优先权日:2006-09-08 标 题 :Processes for the preparation of 1,2,4-oxadiazole benzoic acids 发明人:ALMSTEAD NEIL G; HWANG PETER SEONGWOO; PINES SEEMON; MOON YOUNG-CHOON; TAKASUGI JAMES J 权利人:PTC THERAPEUTICS INC; ALMSTEAD NEIL G; HWANG PETER SEONGWOO; PINES SEEMON; MOON YOUNG-CHOON; TAKASUGI JAMES J 摘要:Provided herein are processes for the preparation of compounds useful for the treatment, prevention or management of diseases associated with a nonsense mutation. More specifically, provided herein are processes for the synthesis of 1,2,4-oxadiazoles. In particular, provided herein are processes useful for the preparation of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid.
专利号:CN-113767094-B 优先权日:2018-12-21 标 题:Synthesis of 3-methyl-1, 2, 4-thiadiazole-5-carbohydrazide and methyl-d 3 deuterated form thereof
专利号:CN-116180112-A 优先权日:2023-03-21 标题:Method for electrochemical synthesis of aryl nitrile by using dialkyl aryl phosphate
参考标题:Methyl Esters Of 2-(N-Hydroxycarbamimidoyl)Benzoyl-Substituted α-Amino Acids As Promising Building Blocks In Peptidomimetic Synthesis: A Comparative Study 作者:Volodymyr A. Tkachuk,Olga V. Hordiyenko,Irina V. Omelchenko,Volodomir V. Medviediev,Axelle Arrault |发布日期:2018.12 摘要:Efficient And Simple Synthetic Protocol For The Synthesis Of A Number Methyl Esters Of 2-(N-Hydroxycarbamimidoyl)Benzoyl-Substituted (S)-α-Amino Acids Via Subsequent Coupling And Hydroxyamination Of 2-Cyanobenzamide Derivatives Has Been Developed. Comparative Analysis Of Three Pseudopeptide Series Based On 2-Cyano- And 2-Amidoxime-Substituted Benzoic Acid And Its Pyridine And Pyrazine Counterparts Has
合成参考文献
摘要:Rudzinski, D. M.; Leadbeater, N. E., Science of Synthesis Knowledge Updates, (2012) 1, 361. 摘要:Yan, G.; Zhang, Y.; Wang, Jianbo, Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 524. 摘要:Ouali, A.; Taillefer, M., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 2, 99.