CAS: 826-73-3; 6,7,8,9-Tetrahydro-5H-Benzo[7]Annulen-5-One

该化合物是属于氯酮类的有机化合物,其特征为双环结构,由苯环组成,与环己酮混合物结合,该化合物一般看起来无色可粉黄黄色液体或固态,视其纯度和温度而定.本祖贝罗酮因其独特的芳香特性而闻名,经常用于有机合成和生产各种化学化合物的中间体.其分子结构有助于其再活动,使它成为制药和农用化学合成的有用建筑块.此外,它可能展示出有趣的生物活动,尽管具体应用可能有所不同.与许多有机化合物一样,适当的处理和安全防范措施对于潜在的毒性和环境影响至关重要.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号35550-94-8 6,7,8,9-tetrahy... | CAS号2270-20-4 5-苯基戊酸 | CAS号70576-29-3 2-but-3-enylben... | CAS号1501-05-9 4-苯甲酰基丁酸 | CAS号313058-73-0 4-phenyl-1-(2,5... | CAS号83692-62-0 syn-11-chloro-1... | CAS号20371-41-9 5-Phenylpentano... | CAS号5759-58-0 2,4,6-三(甲基硫代)-1... | CAS号546051-88-1 2,4-bis(methylt... | CAS号21413-77-4 8-氯-1-苯并软木酮 | CAS号21413-70-7 (5Z)-5-hydroxyi... | CAS号22246-75-9 3,4,5,6-tetrahy... | CAS号21855-89-0 9-Phenyl-6,7-di... | CAS号19844-70-3 5H-Benz°Cyclohe... | CAS号25579-45-7 4-(6,7-Dihydro-... | CAS号251554-42-4 1-硝基-6,7,8,9-四氢... | CAS号7507-93-9 6,7,8,9-四氢-3-硝基...

合成工艺路线路线简述

  • 35550-94-8 = 826-73-3
    反应条件:1.1 Catalysts: Potassium Carbonate,Platinum Solvents: Water; 80 °C
    标题:Platinum Nanoparticles Supported On Polymeric Ionic Liquid Functionalized Magnetic Silica: Effective And Reusable Heterogeneous Catalysts For The Selective Oxidation Of Alcohols In Water
    作者:Vessally,Esmail; Et Al
    参考文献:Rsc Advances 日期:2016 卷标:6(108) 页码:106769-106777]

    2270-20-4 = 826-73-3
    反应条件:1.1 Solvents: 1,1,2,2-Tetrachloroethane; Rt -> 120 °C; 2 H,120 °C; 120 °C -> Rt1.2 Reagents: Water; Cooled
    标题:Synthesis Of 2,3-Benzosuberone
    作者:Gao,Panlong; Et Al
    参考文献:Jingxi Huagong 日期:2010 卷标:27(9) 页码:929-932]

    17910-25-7 = 826-73-3
    反应条件:1.1 Reagents: Zinc Nitrate Hexahydrate (Silica Gel - Bound)
    标题:Microwave Promoted Rapid Oxidative Deoximation Of Oximes Under Solvent-Free Conditions
    作者:Tamami,B.; Et Al
    参考文献:Synthetic Communications 日期:2000 卷标:30(22) 页码:4129-4135]

    = 826-73-3
    反应条件:1.1 Reagents: 4-Nitrophthalonitrile Solvents: Acetonitrile,Water; 48 H
    标题:Oxidative Cleavage Of Ketoximes To Ketones Using Photoexcited Nitroarenes
    作者:Gottemann,Lucas T.; Et Al
    参考文献:Chemrxiv 日期:2023 卷标:1 页码:1-13]

    40562-09-2 = 826-73-3
    反应条件:1.1 Reagents: Oxygen Catalysts: Tetrabutylammonium Chloride,Sodium Tetrafluoroborate,Bis(Acetonitrile)Tetrakis[μ-(2-Hydroxybenzoato-Ko:Ko′)]Dicopper Solvents: Tetrahydrofuran; Rt -> 60 °C; 24 H,60 °C
    标题:Reactions Catalyzed By A Binuclear Copper Complex: Selective Oxidation Of Alkenes To Carbonyls With O2
    作者:Liu,Yuxia; Et Al
    参考文献:Catalysis Science & Technology 日期:2017 卷标:7(23) 页码:5510-5514]

    1075-16-7 = 826-73-3
    反应条件:1.1 Catalysts: Pseudomonas Putida
    标题:Bacterial Oxidation Of Benzocycloalkenes To Yield Monol,Diol And Triol Metabolites
    作者:Boyd,Derek R.; Et Al
    参考文献:Tetrahedron Letters 日期:1991 卷标:32(31) 页码:3887-90]

    70576-29-3 = 826-73-3
    反应条件:1.1 Reagents: Aniline,Benzoic Acid Catalysts: Triphenylphosphine,6,7,8,9-Tetrahydro-7-Methyl-5H-Benzocyclohepten-5-One,Di-μ-Chlorotetrakis[(1,2-η)-Cyclooctene]Dirhodium Solvents: Di-μ-Chlorobis[(1,2,5,6-η)-1,5-Cyclooctadiene]Dirhodium; 26 H,100 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; 10 Min,Rt
    标题:Cooperative Catalysis Approach To Intramolecular Hydroacylation
    作者:Beletskiy,Evgeny V.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2012 卷标:77(14) 页码:5884-5893]

    = 826-73-3
    反应条件:1.1 Reagents: Diisopropylethylamine,Water Catalysts: Rhodium,Bis[μ-[α,α,α′,α′-Tetramethyl-1,3-Benzenedipropanoato(2-)-Ko1,Ko′3:Ko3,K... Solvents: Chloroform; 18 H,40 °C
    标题:A Carbene Strategy For Progressive (Deutero)Hydrodefluorination Of Fluoroalkyl Ketones
    作者:Zhang,Xiaolong; Et Al
    参考文献:Angewandte Chemie 日期:2022 卷标:61(7)]

    5581-75-9 = 826-73-3
    反应条件:1.1 Solvents: 1,2-Dichlorobenzene; 1 Min,Rt -> 220 °C; 10 Min,220 °C
    标题:Efficient Synthesis Of 1-Tetralones From 4-Arylbutyric Acids By Combined Use Of Solid Acid Catalysts And Microwave Irradiation
    作者:Hiroki,Kazuaki; Et Al
    参考文献:Chemistry Letters 日期:2008 卷标:37(3) 页码:320-321]

    = 826-73-3
    反应条件:1.1 Catalysts: Trifluoromethanesulfonic Acid Solvents: Dichloromethane; 5 Min,0 °C1.2 Reagents: Water
    标题:On The Formation Of Seven-Membered Rings By Arene-Ynamide Cyclization
    作者:Brutiu,Bogdan R.; Et Al
    参考文献:Monatshefte Fuer Chemie 日期:2019 卷标:150(1) 页码:3-10]

    1501-05-9 = 826-73-3 [标题:Reaction Conditions
    标题:Novel Benzosuberone-Quinazolinone Derivatives: Synthesis And Antitumour Activity
    作者:Subhashini,N. J. P.; Et Al
    参考文献:Russian Journal Of General Chemistry 日期:2020 卷标:90(10) 页码:1960-1967]

    1501-05-9 = 826-73-3 [标题:Reaction Conditions
    标题:Successive Enveloping Of The Benzene Nucleus With Saturated Rings
    作者:Hellwinkel,Dieter; Et Al
    参考文献:Liebigs Annalen Der Chemie 日期:1985 卷标:(2) 页码:226-38]

    35550-94-8 = 826-73-3
    反应条件:1.1 Reagents: Oxygen Catalysts: Benzoic Acid,Platinum (Complex With Organosilica-Supported Imidazolium Ionic Liquid,Or Silic...),1H-Imidazolium,1,3-Bis[3-(Trimethoxysilyl)Propyl]-,Chloride (1:1) (Mesoporous Organosilica Supported Complexes With Platinum) Solvents: Water; 30 H,90 °C
    标题:Ultrasmall Platinum Nanoparticles Supported Inside The Nanospaces Of Periodic Mesoporous Organosilica With An Imidazolium Network: An Efficient Catalyst For The Aerobic Oxidation Of Unactivated Alcohols In Water
    作者:Karimi,Babak; Et Al
    参考文献:Chemcatchem 日期:2016 卷标:8(5) 页码:906-910]

    35550-94-8 = 826-73-3
    反应条件:1.1 Reagents: Tetrabutylammonium Bromide,Sodium Nitrite,Oxygen Catalysts: Tempo (Sba-15-Supported) Solvents: Acetic Acid; 3 H,60 °C
    标题:Green,Transition-Metal-Free Aerobic Oxidation Of Alcohols Using A Highly Durable Supported Organocatalyst
    作者:Karimi,Babak; Et Al
    参考文献:Angewandte Chemie 日期:2007 卷标:46(38) 页码:7210-7213]

    = 826-73-3
    反应条件:1.1 Reagents: Nickel Solvents: Ethanol; 2 H,Reflux
    标题:Ring Expansion Reaction Of α-Sulfonyl Cyclic Ketones Via Insertion Of Arynes Into C-C: A Facile And Mild Access To Medium- And Large-Sized Benzannulated Carbocycles
    作者:Zhang,Tiexin; Et Al
    参考文献:Tetrahedron Letters 日期:2009 卷标:50(12) 页码:1290-1294]

    2270-20-4 = 826-73-3
    反应条件:1.1 Solvents: 1,1,2,2-Tetrachloroethane; 2 H,120 °C; 120 °C -> Rt1.2 Reagents: Water; Cooled
    标题:Convenient Synthesis Of 1-Benzosuberone
    作者:Gao,Pan-Long
    参考文献:Anhui Nongye Kexue 日期:2010 卷标:38(19) 页码:9948-9949]

    155387-84-1 = 826-73-3
    反应条件:1.1 Reagents: Chromate(1-),Chlorotrioxo-,Zinc (2:1),(T-4)- Solvents: Dichloromethane
    标题:Chromium(Vi) Based Oxidants. Iv. Zinc Chlorochromate Nonahydrate Zn(Clcro3)2-9H2O As An Efficient And Mild Oxidizing Agent. Part 2
    作者:Firouzabadi,Habib; Et Al
    参考文献:Iranian Journal Of Chemistry & Chemical Engineering 日期:1993 卷标:12(1) 页码:32-8]

    155387-84-1 = 826-73-3
    反应条件:1.1 Reagents: Silver Bromate Catalysts: Aluminum Chloride Solvents: Acetonitrile
    标题:Lewis Acid Promoted Reactions. Iv. Oxidation Deprotection Of Trimethylsilyl Ethers With Silver And Sodium Bromates: Agbro3,Nabro3
    作者:Firouzabadi,H.; Et Al
    参考文献:Synthetic Communications 日期:1994 卷标:24(8) 页码:1065-77]

    = 826-73-3
    反应条件:1.1 Reagents: Chromate(1-),Chlorotrioxo-,Zinc (2:1),(T-4)- Solvents: Dichloromethane
    标题:Chromium(Vi) Based Oxidants. Iv. Zinc Chlorochromate Nonahydrate Zn(Clcro3)2-9H2O As An Efficient And Mild Oxidizing Agent. Part 2
    作者:Firouzabadi,Habib; Et Al
    参考文献:Iranian Journal Of Chemistry & Chemical Engineering 日期:1993 卷标:12(1) 页码:32-8]

    20371-41-9 = 826-73-3
    反应条件:1.1 Reagents: Aluminum Chloride Solvents: Carbon Disulfide
    标题:C Rings. Xxxv. Preparation Of Cyclohendecane From Benzosuberan
    作者:Plattner,Pl. A.
    参考文献:Helvetica Chimica Acta 日期:1944 卷标:27 页码:801-10]

    = 826-73-3
    反应条件:1.1 Reagents: Phosphonium,Tetrabutyl-,Diphenyl Phosphate (1:1) Catalysts: 2,4,5,6-Tetra(9H-Carbazol-9-Yl)Isophthalonitrile Solvents: Dichloromethane; 6 H,30 °C
    标题:Synthesis Of Benzo-Fused Cyclic Ketones Via Metal-Free Ring Expansion Of Cyclopropanols Enabled By Proton-Coupled Electron Transfer
    作者:Kikuchi,Tomohiro; Et Al
    参考文献:Organic Letters 日期:2021 卷标:23(12) 页码:4710-4714]

    1075-16-7 = 826-73-3
    反应条件:1.1 Reagents: Pyridine,Tetrabutylammonium Tetrafluoroborate,Oxygen Catalysts: N-Hydroxyphthalimide Solvents: Acetonitrile,2,2,2-Trifluoroethanol; 6 H,25 - 30 °C
    标题:Selective Electrochemical Oxidation Of Aromatic Hydrocarbons And Preparation Of Mono/multi-Carbonyl Compounds
    作者:Li,Zhibin; Et Al
    参考文献:Science China: Chemistry 日期:2021 卷标:64(12) 页码:2134-2141]

    462-80-6 = 826-73-3
    反应条件:1.1 Reagents: Aluminum Chloride,Sodium Chloride
    标题:Reaction Of Arynes With Enamines: A New Ring Expansion Leading To Benzocycloheptenone
    作者:Keyton,Deanna J.; Et Al
    参考文献:Tetrahedron Letters 日期:1969 卷标:(47) 页码:4163-8]

    178100-79-3 = 826-73-3
    反应条件:1.1 Reagents: Antimonate(1-),Pentafluoro(Fluorosulfato-Ko)-,Hydrogen (1:1),(Oc-6-21)- Solvents: 1,1,1,3,3,3-Hexafluoro-2-Propanol; 10 Min,0 °C1.2 Ph 7
    标题:Friedel-Crafts Cyclization Of 1,1-Difluoroalk-1-Enes: Synthesis Of Benzene-Fused Cyclic Ketones Via α-Fluorocarbocations
    作者:Ichikawa,Junji; Et Al
    参考文献:Synthesis 日期:2005 卷标:(1) 页码:39-46]

    = 826-73-3
    反应条件:1.1 Reagents: Trifluoroacetic Acid Catalysts: 2,4,5,6-Tetra(9H-Carbazol-9-Yl)Isophthalonitrile Solvents: Dimethyl Sulfoxide; 7 H,Rt
    标题:Decarboxylative Intramolecular Arene Alkylation Using N-(Acyloxy)Phthalimides,An Organic Photocatalyst,And Visible Light
    作者:Sherwood,Trevor C. ; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2019 卷标:84(13) 页码:8360-8379]

    1501-05-9 = 826-73-3 [标题:Reaction Conditions
    标题:Design,Synthesis And In Vitro Anti-Tuberculosis Activity Of Benzo[6,7]Cyclohepta[1,2-B]Pyridine-1,2,3-Triazole Derivatives
    作者:Sajja,Yasodakrishna; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2017 卷标:27(23) 页码:5119-5121
5-苯基戊酰氯置于三氯化铝体系中,用 二硫化碳 作为反应溶剂,化学反应生成 1-苯并环庚酮
参考文献:Synthesis Of Dicyclopenta[ef,Kl]Heptalene (Azupyrene). Ii. Routes From 1,6,7,8,9,9A-Hexahydro-2H-Benzo[c,D]Azulen-6-One And 5-Phenylpentanoic Acid
标题:Synthesis Of Dicyclopenta[ef,Kl]Heptalene (Azupyrene). Ii. Routes From 1,6,7,8,9,9A-Hexahydro-2H-Benzo[c,D]Azulen-6-One And 5-Phenylpentanoic Acid
摘要:
DOI:10.1021/jo00948A002

海关参考信息

专利信息


专利号:US-5932743-A
优先权日:1997-08-21
标 题:Methods for the solid phase synthesis of substituted indole compounds
发明人：COLLINI MICHAEL D; ELLINGBOE JOHN W
权利人:AMERICAN HOME PROD
摘要:The present invention relates to novel substituted indole compounds of formula (I) having pharmacological activity, to processes for their preparation, to solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.

专利号:US-5567830-A
优先权日:1994-02-14
标题 :Process for synthesis of acetylenic carbinols
发明人：UPASANI RAVINDRA B
权利人:COCENSYS INC
摘要:A method for the preparation of an acetylenic alcohol by reaction of 1,2-dibromoethylene with an alkyl, aryl an heteroaryl lithium in an inert solvent, followed by reaction with a carbonyl-containing compound to give an acetylenic alcohol is disclosed.

专利号:WO-9909007-A1
优先权日:1997-08-21
标题:Solid phase synthesis of 2,3-disubstituted indole compounds
发明人：COLLINI MICHAEL DAVID; ELLINGBOE JOHN WATSON
权利人:AMERICAN HOME PROD
摘要:The present invention relates to novel substituted indole compounds of formula (I) having pharmacological activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.

专利号:US-4876361-A
优先权日:1986-12-22
标 题:Process for the production of thiophenes from alpha-methylene ketones in the single-stage process and new ortho-fused thiophenes produced by means of the process
发明人：CZOGALLA CLAUS-D
权利人:VON DER HAAR CZOGALLA RITA
摘要:Described is a novel process which can be carried out as a single-stage synthesis for the production of substituted and/or b,d- ortho-fused thiophenes. Serving as starting compounds and alpha -methylene ketones which are reacted in an preferably alcoholic solvent with bromine whereafter the formed intermediate product after separation from the solvent is reacted directly with a sulphurising agent. Preferably under reflux conditions in a suitable solvent to form the end product. In this way also hitherto unknown ortho-fused thiophene compounds are synthesized more especially those with 5 or 9 rings condensed with one another.

专利号:CN-1602298-A
优先权日:2001-10-12
标 题:Process for the synthesis of oxygen-substituted benzocycloheptenes and their use as useful intermediates in the preparation of tissue-selective estrogens

专利号:US-4992574-A
优先权日:1987-11-06
标题:Benzocycloheptene derivatives
发明人：KLAUS MICHAEL; MOHR PETER
权利人:HOFFMANN LA ROCHE
摘要:A compound of the formula ##STR1## wherein R 1 is hydroxy, lower-alkoxy, amino, mono- or di-lower-alkylamino; n R 2 is hydrogen, alkyl, akoxy or halogen; n R 3 , R 4 , R 5 , R 6 , R 11 and R 12 independently are hydrogen or lower-alkyl; n R 3 and R 5 taken together are methylene or hydroxymethylene; n R 7 , R 8 , R 9 and R 10 independently are hydrogen or lower-alkyl; n R 11 and R 12 taken together are oxo or spiro-cyclo-lower alkyl; or R 11 is hydrogen and R 12 is hydroxy or acetoxy; and one of the residues R 13 and R 14 is hydrogen and the other is lower-alkyl or trifluoromethyl, as well as physiologically compatible salts of carboxylic acids of formula I, which can be used as medicaments, especially for the treatment of neoplasms, acne and psoriasis, are described. The compounds of the invention can be prepared by the synthesis of the C(R 13 )â•?C(R 14 ) double bond according to Wittig from a corresponding bicyclic component and a corresponding monocyclic component and optional subsequent transformation of functional grous.

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主要参考文献

参考标题:Iron-Catalyzed Synthesis Of 2H-Imidazoles From Oxime Acetates And Vinyl Azides Under Redox-Neutral Conditions
作者:Zhongzhi Zhu,Xiaodong Tang,Jianxiao Li,Xianwei Li,Wanqing Wu,Guohua Deng,Huanfeng Jiang |发布日期:2017.3.17
摘要:A Novel And Versatile Method For The Synthesis Of 2H-Imidazoles Via Iron-Catalyzed [3 + 2] Annulation From Readily Available Oxime Acetates With Vinyl Azides Has Been Developed. This Denitrogenative Process Involved N-O/n-N Bond Cleavages And Two C-N Bond Formations To Furnish 2,4-Substituted 2H-Imidazoles. This Protocol Was Performed Under Mild Reaction Conditions And Needed No Additives Or Ligands

合成参考文献


摘要:Okamoto, K.; Ohe, K., Science of Synthesis Knowledge Updates, (2020) 1, 89.
摘要:Scott, P. J. H., Science of Synthesis Knowledge Updates, (2013) 4, 287.
摘要:Jie, X.; Su, W., Science of Synthesis, (2022) , 2.
摘要:Buitrago Santanilla, A.; Leighton, J. L., Science of Synthesis: Stereoselective Synthesis, (2011) 2, 420.
摘要:Cheng, Q.; Shen, X., Science of Synthesis: Knowledge Updates, (2025) 2.
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