3-氨基-4,5-二氢-1-苯基吡唑置于盐酸体系中,化学反应生成 菲尼酮 参考文献:Pietra,Bollettino Scientifico Della Facolta Di Chimica Industriale Di Bologna,1953,Vol. 11,P. 78,80 标题:Pietra,Bollettino Scientifico Della Facolta Di Chimica Industriale Di Bologna,1953,Vol. 11,P. 78,80
专利号:US-11542269-B2 优先权日:2018-01-03 标 题:Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof 发明人:CHOI HYEONG-WOOK; FANG FRANCIS G 权利人:EISAI R&D MAN CO LTD 摘要:The invention provides methods utilizing Prins reaction in the preparation of compounds that may be useful as intermediates in the synthesis of halichondrin macrolides and analogs thereof. The invention also provides compounds that may be useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.
专利号:US-10913749-B2 优先权日:2015-05-07 标 题 :Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides 发明人:FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E 权利人:EISAI R&D MAN CO LTD 摘要:The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.
专利号:US-11136335-B2 优先权日:2016-06-30 标题:Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof 发明人:CHASE CHARLES E; CHOI HYEONG-WOOK; ENDO ATSUSHI; FANG FRANCIS G; KIM DAE-SHIK 权利人:EISAI R&D MAN CO LTD 摘要:The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.
专利号:US-4592867-A 优先权日:1984-10-19 标题:Synthesis method for reductant precursor 发明人:YU TERRY T; YEN MEI-RONG 权利人:ENERGY CONVERSION DEVICES INC 摘要:A synthesis method is provided for the synthesis of quinone compounds of the formula ##STR1## where n is 0-3, Y 1 is alkoxy, Y 2 is alkoxy, chloro, bromo or hydrogen and R' and R' each and independently are hydrogen, alkyl or phenyl. These compounds are useful as reductant precursors in tellurium imaging compositions.
专利号:US-2014378538-A1 优先权日:2011-12-14 标 题:Methods of responding to a biothreat 发明人:BANCEL STEPHANE 权利人:MODERMA THERAPEUTICS INC 摘要:The present disclosure provides for devices, in particular mobile devices, which may be used in the synthesis of modified nucleic acid molecules, in particular modified mRNA molecules. The device for making the modified nucleosides, modified nucleotides and modified nucleic acids (e.g., mRNA) disclosed herein may be mobile devices comprising at least one sample block for insertion of one or more sample vessels, a device base with electronic control units for the sample block, a voltage supply, and one or more reagent(s) for the synthesis of at least one nucleic acid.
专利号:US-5527824-A 优先权日:1985-07-22 标题 :Substituted Di-T-Butlyphenols useful for inhibiting leukotriene synthesis 发明人:SCHERRER ROBERT A 权利人:RIKER LABORATORIES INC 摘要:Substituted Di-T-Butylphenols useful for inhibiting the synthesis of leukotrienes are disclosed.
[参考文献]: Moon C, Et Al. Phenidone, A Dual Inhibitor Of Cyclooxygenases And Lipoxygenases, Ameliorates Rat Paralysis In Experimental Autoimmune Encephalomyelitis By Suppressing Its Target Enzymes. Brain Res. 2005;1035(2):206-210. [参考文献]: Petrakiev A, Et Al. Emission Spectral Analysis Using Photographic Plates Treated With A Phenidone Developer. Talanta. 1969;16(12):1583-1587. [参考文献]: Stern N, Et Al. The Lipoxygenase Inhibitor Phenidone Is A Potent Hypotensive Agent In The Spontaneously Hypertensive Rat. Am J Hypertens. 1993;6(1):52-58. [参考文献]: Ender Büyükgüzel, Et Al. The Influence Of Chronic Eicosanoid Biosynthesis Inhibition On Life History Of The Greater Waxmoth, Galleria Mellonella And Its Ectoparasitoid, Bracon Hebetor. J Insect Physiol. 2011 Apr;57(4):501-7. [参考文献]: G P Rossi, Et Al. Endothelin-1 Stimulates Aldosterone Synthesis In Conn'S Adenomas Via Both A And B Receptors Coupled With The Protein Kinase C- And Cyclooxygenase-Dependent Signaling Pathways. J Investig Med. 2000 Sep;48(5):343-50.
合成参考文献
参考文献:10.1155/2011/385780 摘要:Burnett BP, Bitto A, Altavilla D, Squadrito F, Levy RM, Pillai L. Flavocoxid inhibits phospholipase A2, peroxidase moieties of the cyclooxygenases (COX), and 5-lipoxygenase, modifies COX-2 gene expression, and acts as an antioxidant. Mediators Inflamm. 2011;2011():385780.