专利号:US-9840468-B1 优先权日:2016-12-30 标 题:Methods for the preparation of 6-aminoisoquinoline 发明人:CHAMBOURNIER GILLES; DELONG MITCHELL A 权利人:AERIE PHARMACEUTICALS INC 摘要:Described are methods for the preparation of 6-aminoisoquinoline, a useful intermediate compound in the synthesis of kinase inhibitors.
专利号:US-7943723-B2 优先权日:2006-12-21 标 题:Process for the synthesis of ethers of aromatic acids 发明人:RITTER JOACHIM C 权利人:DU PONT 摘要:The inventions disclosed herein include processes for the preparation of an ether of an aromatic acid, processes for the preparation of products into which such an ether can be converted, the use of such processes, and the products obtained and obtainable by such processes. A key feature of the processes described is the use of a solvent comprising an alcohol ROH and an alcoholate RO − M + .
专利号:US-8207374-B2 优先权日:2006-12-21 标 题:Process for the synthesis of ethers of aromatic acids 发明人:RITTER JOACHIM C 权利人:RITTER JOACHIM C; DU PONT 摘要:Ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a copper (I) or copper (II) source and a diketone ligand that coordinates to copper.
专利号:US-2015293109-A1 优先权日:2012-10-29 标题 :Fluorescent Chemical Dye for Visualization of Neural Stem Cell Symmetric and Asymmetric Division 发明人:CHANG YOUNG-TAE; YUN SEONG-WOOK; HA HYUNG HO 权利人:UNIV SINGAPORE; AGENCY SCIENCE TECH & RES 摘要:A fluorescent rosamine dye having specificity for neural stem cells, specifically, proliferative neural stem cells, and represented by Structural Formula (I): wherein X is an anion, is described herein. Synthesis of the fluorescent rosamine dye and use of the fluorescent rosamine dye to detect symmetric and asymmetric division of neural stem cells are also described.
专利号:US-2011060118-A1 优先权日:2009-09-02 标 题:Process for the synthesis of fluorinated ethers of aromatic acids 发明人:RITTER JOACHIM C; MOLOY KENNETH GENE; POLLINO JOEL M; MAHAJAN DU SURBHI 权利人:DU PONT 摘要:Fluorinated ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a copper (I) or copper (II) source and a Schiff base ligand that coordinates to copper. The fluorinated ethers of aromatic acids made using the process described herein can be applied to, e.g., fibers, yarns, carpets, garments, films, molded parts, paper and cardboard, stone, and tile to impart soil, water and oil resistance. By incorporating the fluorinated ethers of aromatic acids, or diesters thereof, into polymer backbones, more lasting soil, water and oil resistance, as well as improved flame retardance, can be achieved.
专利号:US-7985825-B2 优先权日:2006-12-21 标 题 :Process for the synthesis of ethers of aromatic acids 发明人:RITTER JOACHIM C 权利人:DU PONT 摘要:Ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a halogenated aromatic acid such as is described by the structure of Formula II n nwherein each X is independently Cl, Br or I; the reaction mixture further comprising;n (i) a polar protic solvent, a polar aprotic solvent or an alcoholic solvent containing the alcoholate RO-M+ (wherein M is Na or K), wherein the polar protic solvent, polar aprotic solvent or alcoholic solvent is either ROH or is a solvent that is less acidic than ROH; (ii) a copper (I) or copper (II) source; and (iii) an amino acid ligand that coordinates to copper, wherein the ligand comprises an amino acid in which the amine nitrogen and the carboxyl carbon are separated by no more than two carbon atoms.
参考文献:10.1107/s1600536811011962 摘要:Win YF, Choong CS, Ha ST, Quah CK, Fun HK. (2-Chloro-4-nitro-benzoato)(methanol)triphenyl-tin(IV). Acta Crystallogr Sect E Struct Rep Online. 2011 May 01;67(Pt 5):m535.