CAS: 108-62-3; Metaldehyde

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CAS号75-07-0 乙醛 | CAS号58052-80-5 六氢三甲基-S-三嗪 | CAS号75-34-3 1,1-二氯乙烷标准溶液 | CAS号75-87-6 三氯乙醛 | CAS号123-63-7 三聚乙醛 | CAS号75-07-0 乙醛

乙醛置于硫酸体系中,用 水 用作溶剂,化学反应生成四聚乙醛
参考文献:Method Of Phenol And Carbonyl Production
标题:Method Of Phenol And Carbonyl Production
摘要:本发明描述了一种高产率和简化的方法,通过芳香族过氧化物的催化分解来制备酚和羰基化合物,如乙醛.合成过程通常包括在正气氛下和高温(80至100oc)下,在存在催化剂量(0.01-0.8质量百分比(%))的情况下,分解过氧化物,催化剂为具有以下结构的阴离子表面活性剂r-oso3M或r-op3Z2,其中"m"为na或k,"z"为na,K或含有十至十四个碳(c10-C14)的烷基基团,而"r"为由十至十四个碳(c10-C14)组成的烷基基团.

专利信息

专利号:US-11046978-B2
优先权日:2016-03-16
标 题:Synthesis of isoprenoids and derivatives
发明人：GONZALEZ RAMON; CLOMBURG JAMES M; CHEONG SEOKJUNG
权利人:UNIV RICE WILLIAM M
摘要:This disclosure generally relates to the use of enzyme combinations or recombinant microbes comprising same to make isoprenoid precursors, isoprenoids and derivatives thereof including prenylated aromatic compounds. Novel metabolic pathways exploiting Claisen, aldol, and acyioin condensations are used instead of the natural mevalonate (MVA) pathway or 1-deoxy-d-xylulose 5-phosphate (DXP) pathways for generating isoprenoid precursors such as isopentenyl pyrophosphate (IPP), dimethylallyl pyrophosphate (DMAPP), and geranyl pyrophosphate (GPP). These pathways have the potential for better carbon and or energy efficiency than native pathways. Both decarboxylative and non-carboxylative condensations are utilized, enabling product synthesis from a number of different starting compounds. These condensation reactions serve as a platform for the synthesis of isoprenoid precursors when utilized in combination with a variety of metabolic pathways and enzymes for carbon rearrangement and the addition/removal of functional groups. Isoprenoid alcohols are key intermediary products for the production of isoprenoid precursors in these novel synthetic metabolic pathways.

专利号:US-7888337-B2
优先权日:2007-08-31
标 题 :Synthesis of oseltamivir containing phosphonate congeners with anti-influenza activity
发明人：WONG CHI-HUEY; FANG JIM-MIN; SHIE JIUN-JIE; CHENG YIH-SHYUN EDMOND; JAN JIA-TSRONG
权利人:ACADEMIA SINICA
摘要:Novel phosphonate compounds are described. The compounds have activity as neuraminidase inhibitors against wild-type and H274Y mutant of H1N1 and H5N1 viruses. The present disclosure also provides an enantioselective synthetic route to known neuraminidase inhibitors oseltamivir and the anti-flu drug Tamiflu®, as well as novel phosphonate compounds, via D-xylose. Another efficient and flexible synthesis of Tamiflu and the highly potent neuraminidase inhibitor Tamiphosphor was also achieved in 11 steps and >20% overall yields from the readily available fermentation product (1S-cis)-3-bromo-3,5 -cyclohexadiene-1,2-diol. Most of the reaction intermediates were obtained as crystals without tedious purification procedures. The key transformations include an initial regio- and stereoselective bromoamidation of a bromoarene cis-dihydrodiol, as well as the final palladium-catalyzed carbonylation and phosphonylation.

专利号:US-5905136-A
优先权日:1994-12-21
标 题 :Polycondensation catalyzers for the synthesis of polyethylene terephtalate
发明人：PO RICCARDO; PELOSINI LUIGI
权利人:MONTEFIBRE SPA; INCA INTERNATIONAL SPA
摘要:PCT No. PCT/EP95/04883 Sec. 371 Date Jun. 19, 1997 Sec. 102(e) Date Jun. 19, 1997 PCT Filed Dec. 6, 1995 PCT Pub. No. WO96/19518 PCT Pub. Date Jun. 27, 1996The subject is a class of catalyzers to be used in the stage of polycondensation of the synthesis of poly(ethylene terephtalate), consisting of metal and non-metal derivatives in composition with sulfonic acids mixed with titanium compounds so that the final polymer contains a sulfur quantity of 5-60 ppm and a quantity of metals between 2 and 100 ppm.

专利号:US-10323010-B2
优先权日:2015-07-20
标题 :Methods of chemical synthesis of substituted 10H-phenothiazine-3,7-diamine compounds
发明人：STOREY JOHN MERVYN DAVID; LARCH CHRISTOPHER PAUL; KEMP STEVEN JOHN; CLUNAS SCOTT; NICOLL SARAH LOUISE; GIBBARD HELEN SARAH; SIMPSON MICHAEL; SINCLAIR JAMES PETER; MARSHALL COLIN
权利人:WISTA LAB LTD
摘要:The present invention pertains generally to the field of chemical synthesis, and more particularly to methods of chemical synthesis which include the step of preparing a substituted 10H-phenothiazine-3,7-diamine compound of Formula (1) by a step of selective alkylation by reductive amination, in which the corresponding unsubstituted diamine of Formula (4) is reacted with aldehyde/ketone, under reductive amination conditions. The present invention also relates to such methods which incorporate additional subsequent and/or preceding steps, for example, to prepare compounds of Formulae (2) and (3) from compounds of Formula (1), and to prepare compounds of Formula (4) from, for example, compounds of Formulae (5), (6), (7), (8), and (9). Compounds of Formula (1), Formula (2), and Formula (3) are useful, for example, in the treatment of diseases of protein aggregation, such as Alzheimer's disease.

专利号:WO-9102067-A1
优先权日:1989-07-27
标题:Regulation of nerve growth factor synthesis in the central nervous system
发明人：LINDHOLM DAN BJARNE; THOENEN HANS FRIEDRICH ERWIN; HENGERER BASTIAN
权利人:MAX PLANCK GESELLSCHAFT
摘要:The present invention relates to a method for regulating levels of nerve growth factor in the central nervous system, and is based on the discovery that in vivo synthesis of nerve growth factor may be regulated by various cytokines. In specific embodiments, intracerebroventricular injection of interleukin 1, fibroblast growth factor, or TGFβ1 increase synthesis of nerve growth factor and its mRNA. The methods of the present invention may be useful in the treatment of various neurologic diseases or disorders, including Alzheimer's disease.

专利号:US-4691008-A
优先权日:1984-03-27
标 题:Process for the low-racemization preparation of peptide intermediates of the synthesis of gonadorelin and gonadorelin analogs, and new intermediates for this process
发明人：UHMANN RAINER; RADSCHEIT KURT
权利人:HOECHST AG
摘要:The invention relates to a process for the preparation of peptides of the formula I U-A1-A213 A3-A4-A5-X (I) in which U denotes a urethane protective group, A1 denotes Trp or D-Trp, A2 denotes Ser, Ala or Thr, A3 denotes Tyr or Phe, A4 denotes Gly, the residue of a D-amino acid or the residue of a D-amino acid derivative, A5 denotes Leu, N-methyl-Leu, N-ethyl-Leu, Ser(But), Cys(But), Asp(OBut), Glu(OBut), Orn(Boc) or Lys(Boc) and X denotes OBut or A6-Pro-Y, where A6 represents Arg, Orn, Lys or homoarginine, and Y represents Gly-NH2, NH-NH-CO-NH2, (C1-C3)-alkylamino, cyclopropylamino, (C1-C3)-alkylamino which is substituted with hydroxyl or fluorine, or cycloalkylamino which is substituted with hydroxyl or fluorine, using tripeptides of the formula II, U-A1-A2-A3-OH, in which the residues are defined as above. The invention also relates to peptides of the formula II as intermediates in this process.