CAS: 1253282-31-3; Fmoc-Aph(Hor)-Oh

专利信息

专利号:US-12098218-B2
优先权日:2015-12-17
标题 :Process for the manufacture of degarelix and its intermediates
发明人：RICCI ANTONIO; ZANON JACOPO; CABRI WALTER; GURYANOV IVAN; ORLANDIN ANDREA; BIONDI BARBARA; FORMAGGIO FERNANDO; VISENTINI DARIO
权利人:FRESENIUS KABI IPSUM S R L
摘要:The present invention provides a manufacturing process for preparing a peptide, preferably a decapeptide, such as degarelix, by incorporating p-nitro-phenylalanin in the amino acid sequence preferably during stepwise solid phase synthesis, and converting these into the required amino acids Aph(Hor) and/or D-Aph(Cbm), preferably while attached to a solid phase. The invention further provides intermediates useful in the manufacturing process.

专利号:CN-103351428-A
优先权日:2013-08-05
标 题 :Synthesis of degarelix by a solid-phase fragmentation method

专利号:CN-112876541-B
优先权日:2019-11-29
标题:A kind of solid-phase synthesis method of degarelix

专利号:CN-102329373-A
优先权日:2011-09-29
标题 :Solid Phase Synthesis Process of Degarelix

专利号:CN-103351428-B
优先权日:2013-08-05
标题:A kind of solid phase fragment method synthesis Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-4Aph(Hor)-D-4Aph(Cbm)-Leu-Lys(iPr)-Pro-D-Ala-NH2