CAS: 130-15-4; 1,4-Naphthoquinone

上下游产品

diazomethane phthalic anhydride naphthalene 1,4-Dihydroxynaphthalene -1H-pyrazole(1,4)-Naphthoquinono3,2-c-1H-pyrazole 2-chloroanthracene-9,10-dione 2-piperidino-1,4-naphthoquinone 1,4-Dihydroxynaphthalene

1-Acetoxy-4-(4-Bromobenzyl)Oxynaphthalene置于(1,1'-Bis(Diphenylphosphino)Ferrocene)Palladium(II) Dichloride,双氧水,氧气,Potassium Acetate,Sodium Hydroxide体系中,用 乙醇,N,N-二甲基甲酰胺 用作溶剂,化学反应 3.33H,反应生成1,4-萘醌
参考文献:H 2 O 2介导的硼酸酯探针对氧化还原循环分子的自催化脱保护的指数分子扩增
标题:H 2 O 2介导的硼酸酯探针对氧化还原循环分子的自催化脱保护的指数分子扩增
摘要:在本文中,描述了一种基于h 2 O 2介导的硼酸酯探针脱保护为氧化还原循环化合物的新分子自催化反应方案,在o 2和还原剂或酶的存在下产生指数信号增益.为此,设计了围绕萘醌/萘氢醌氧化还原活性核构建的新型化学传感探针,并被自消旋的硼酸酯保护基团掩盖.使用这些探针,可以通过使用uv / Visible或荧光光学检测或通过电化学监测获得具有特征性滞后和指数相的典型自催化动力学迹线.浓度低到0.5μ的检测米ħ 2 ö在相对较短的时间内(<1小时)即可获得2和0.5 N M的萘醌衍生物.通过与自动催化相关的两个交叉活化的催化环的动力学分析,确定了控制自动催化反应网络的关键参数,间接表明分析性能目前受到硼酸盐探针缓慢的非特异性自保护作用的限制.总的来说,目前的结果证明了这种新的指数分子扩增策略的潜力,由于其通用的性质和模块性,该方法对于与涉及h 2 O 2的各种生物测定方法的耦合是很有前途的. 或氧化
Doi:10.1002/chem.201900627

专利信息

专利号:US-6531591-B1
优先权日:1999-07-07
标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates
发明人：FENSHOLDT JEF
权利人:EXIQON AS
摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.

专利号:US-11912654-B2
优先权日:2021-09-03
标 题:Process for stereospecific synthesis of vitamin K2 and its novel intermediates
发明人：MEHTA DILIP; SHASHTRI MAYANK; RAJU BNS; SHAH ASHWIN; VORA PARIN; MAHALE UMAKANT
权利人:SYNERGIA LIFE SCIENCES PVT LTD
摘要:The present disclosure relates to a novel process for the synthesis of stereospecific compounds of Vitamin K2 group in general and Vitamin K2-7. The present disclosure further discloses novel intermediates useful in the synthesis of stereospecific Vitamin K2-7. Compounds of the Vitamin K2 group obtained are crystalline and exhibit well defined melting points.

专利号:WO-2023031841-A1
优先权日:2021-09-03
标题:A process for the stereospecific synthesis of vitamin k2 and its intermediates
发明人：MEHTA DILIP; SHASHTRI MAYANK; RAJU BNS; VORA PARIN; MAHALE UMAKANT
权利人:SYNERGIA LIFE SCIENCES PVT LTD
摘要:The present disclosure relates to a novel process for the synthesis of stereospecific compounds of Vitamin K2 group in general and Vitamin K2-7, in particular. It also discloses novel intermediates useful in the synthesis of stereospecific Vitamin K2-7. Compounds of the Vitamin K2 group obtained are crystalline and exhibit well defined melting points.

专利号:EP-1202998-B1
优先权日:1999-07-07
标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates
发明人：FENSHOLDT JEF
权利人:EXIQON AS
摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.

专利号:WO-2024013633-A1
优先权日:2022-07-11
标 题 :Process for the synthesis of vitamin k2
发明人：SHASTRI MAYANK; BAIKAR MRUNALI H; VORA PARIN K; BNS RAJU
权利人:SYNERGIA LIFE SCIENCES PVT LTD
摘要:The present disclosure relates to the synthesis of Vitamin K2 bearing varying prenyl side chains. The synthesis comprises the reaction of phenyl sulfone of tert-butyl dimethyl silyl (TBDMS) protected mono prenyl menadiol with prenyl halides bearing varying prenyl units in the presence of the phase transfer catalyst followed by reductive desulphonation to yield TBDMS ether of Vitamin K2. The TBDMS ether is then oxidized in the presence of chromium trioxide and periodic acid to yield the corresponding Vitamin K2.

专利号:US-6998484-B2
优先权日:2000-10-04
标 题:Synthesis of purine locked nucleic acid analogues
发明人：KOCH TROELS; JENSEN FLEMMING REISSIG
权利人:SANTARIS PHARMA AS
摘要:The present invention relates to a new method for the synthesis of purine LNA (Locked Nucleic Acid) analogues which provides a higher overall yield. The method comprising a regioselective 9-N purine glycosylation reaction followed by a one-pot nucleophilic aromatic substitution reaction of the 6-substituent in the purine ring and simultaneous nucleophile-induced intramolecular ring closure of the C-branched carbohydrate to form novel purine LNA analogues. The novel strategy is illustrated by the synthesis of the novel compound (1S,3R,4R,7S)-7-benzyloxy-1-methanesulfonylmethyl-3-(guanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane which is easily converted into (1S,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-3-((2-N-isobutyrylguanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane after isobutyryl protection of the 2-amino purine group and subsequent substitution of 1-methanesulfonyl with benzoate, debenzoylation and debenzylation.