CAS: 15891-49-3; (S)-2-Acetamidohexanoic Acid

相似化合物

7682-15-7 7682-16-8 54896-21-8

上下游产品

CAS号56247-43-9 N-Acetyl-DL-nor... | CAS号327-57-1 L-正亮氨酸 | CAS号108-24-7 乙酸酐 | CAS号327-57-1 L-正亮氨酸

L-正亮氨酸,乙酸酐置于碳酸氢钠体系中,用 水 用作溶剂,化学反应 5.0H,以31%的收率获得乙酰-L-正亮氨酸
参考文献:通过生物启发的立体选择性γ-C-H键键渗法普遍获得修饰的α-氨基酸
标题:通过生物启发的立体选择性γ-C-H键键渗法普遍获得修饰的α-氨基酸
摘要:α‐氨基酸代表了宝贵的一类天然产物,被用作生物和化学合成的基础.由于可用的天然氨基酸数量有限,并且它们在蛋白质组学,诊断,药物递送和催化中的广泛应用,对开发制备修饰的类似物的方法的需求日益增加.在这里,我们表明使用了生物启发性的锰催化剂和h 2 O 2在温和的条件下,可通过γ-C-H键内酯化作用获得修饰的α-氨基酸.该系统可有效靶向α-取代的和非手性α,α-二取代的α-氨基酸的1°,2°和3°γ-C-H键,具有出色的位点选择性,非常好的非对映选择性和(如果适用)对映选择性.该方法可以被认为是完善的有机金属程序的替代方法.
Doi:10.1002/anie.202007899

专利信息

专利号:US-9644226-B2
优先权日:2012-08-22
标题 :Method for producing vectors containing a gene coding for an enzyme having reduced or deactivated feedback inhibition and the use thereof for producing amino acids and nucleotides
发明人：SCHENDZIELORZ GEORG; BINDER STEPHAN; EGGELING LOTHAR; BOTT MICHAEL
权利人:FORSCHUNGSZENTRUM JUELICH GMBH
摘要:A method for producing vectors containing a gene coding for an enzyme having reduced or deactivated feedback inhibition and to the use thereof for producing amino acids and nucleotide. Genes coding for feedback-inhibited enzymes are mutagenized in vitro, —ligated into vectors in a further step—the vectors are each transformed in a microorganism containing a metabolite sensor in a further step, which brings about the synthesis of a fluorescent protein at an increased metabolite concentration, —whereupon microorganisms exhibiting increased or maximum fluorescence are selected; and —the vectors that contain a gene coding for an enzyme having reduced or deactivated feedback inhibition are isolated from microorganisms having increased or maximum fluorescence.

专利号:CN-117843715-A
优先权日:2023-12-15
标题 :Liquid phase synthesis method of melanoputan-II