CAS: 18125-46-7; (R)-2-Amino-3-(4-Fluorophenyl)Propanoic Acid

相似化合物

51-65-0 1132-68-9 169243-86-1

上下游产品

CAS号654054-42-9 (R)-2-amino-1-(... | CAS号51-65-0 4-氟-DL-苯丙氨酸 | CAS号103-81-1 2-苯乙酰胺 | CAS号7761-30-0 3-(4-氟苯基)-2-氧代丙酸 | CAS号654054-26-9 ((3aS,6R,7aR)-8... | CAS号69216-82-6 (R)-N-acetyl-p-... | CAS号1994-30-5 | CAS号380-71-2 diethyl 2-aceta... | CAS号17481-06-0 N-乙酰基-4-氟-DL-苯丙氨酸

对氟肉桂酸置于ammonium Hydroxide,硼烷铵络合物体系中,用 Aq. Buffer 用作溶剂,以49%的收率获得4-氟-D-苯丙氨酸
参考文献:苯丙氨酸氨裂解酶合成 D-和 L-苯丙氨酸衍生物:多酶级联过程
标题:苯丙氨酸氨裂解酶合成 D-和 L-苯丙氨酸衍生物:多酶级联过程
摘要:通过将苯丙氨酸解氨酶 (Pal) 胺化与化学酶脱外消旋(基于立体选择性氧化和非选择性还原).还开发了一种简单的高通量固相筛选方法来鉴定具有较高非天然d-苯丙氨酸形成率的 Pal.在化学酶级联中利用了最佳变体,从而提高了d配置产品的产量和 Ee 值.此外,该系统还扩展到制备低浓度的l-苯丙氨酸.Ee 值使用pal胺化.
Doi:10.1002/anie.201410670

专利信息

专利号:WO-2009080631-A2
优先权日:2007-12-21
标 题 :Chemo-enzymatic synthesis of a c-terminal aryl amide of an amino acid or peptide
发明人：QUAEDFLIEG PETER JAN LEONARD MARIO; NUIJENS TIMO; CUSAN CLAUDIA
权利人:DSM IP ASSETS BV; QUAEDFLIEG PETER JAN LEONARD MARIO; NUIJENS TIMO; CUSAN CLAUDIA
摘要:The present invention relates to a method for preparing an aryl amide, comprising reacting an aryl amine with a compound selected from N-protected amino acids and optionally N-protected peptides in the presence of a hydrolytic enzyme. The invention further relates to the use of a compound obtained in a method according to the invention in the manufacture of a diagnostic. In addition the invention relates to the use of a compound obtained in a method according to the invention as a substrate for a proteolytic enzyme.

专利号:US-2022243244-A1
优先权日:2019-10-10
标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
发明人：ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-11453699-B2
优先权日:2017-04-19
标 题:Antimicrobial compounds and/or modulators of microbial infections and methods of using the same
发明人：SCOTT WILLIAM LEONARD; O'DONNELL MARTIN JAMES; SAMARITONI JACK GENO
权利人:UNIV INDIANA RES & TECH CORP
摘要:Some embodiments include compounds that can inhibit the growth of bacterial and/or inhibit or reduce microbial infections caused by one or more microorganisms (e.g., Pseudomonas aeruginosa and Cryptococcus neoformans) and methods of using these compounds to treat microbial infection and outbreaks and/or to reduce the formation of biofilms. Other embodiments include synthesis of the compounds that can inhibit the growth of one or more microorganisms and/or inhibit or reduce microbial infections.

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-8541191-B2
优先权日:2008-08-29
标 题 :Hydrolases, nucleic acids encoding them and methods for biocatalytic synthesis of structured lipids
发明人：DAYTON CHRISTOPHER L G; HITCHMAN TIM; KLINE KATIE; LYON JONATHAN; WALL MARK A; BARTON NELSON R
权利人:DAYTON CHRISTOPHER L G; HITCHMAN TIM; KLINE KATIE; LYON JONATHAN; WALL MARK A; BARTON NELSON R; BUNGE OILS INC
摘要:Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity, e.g., lipases, saturases, palmitases and/or stearatases and methods for preparing low saturate or low trans fat oils, such as low saturate or low trans fat animal or vegetable oils, e.g., soy or canola oils.