合成目标产物 Trans-2-Nonenal 主要起始原料 1-Octene And Acrolein
(文献来源)合成步骤主要原料 1-Octene 和 Acrolein
(Z)-N-(N-Heptylidene)Methylamine N-Oxide置于氢氟酸体系中,用 乙腈,苯 用作溶剂,化学反应 0.5H,反应生成反式-2-壬烯醛 参考文献:Nitrone Cycloadditions. An Efficient Method For The Homologation Of Aldehydes To .Alpha.,.Beta.-Unsaturated Aldehydes 标题:Nitrone Cycloadditions. An Efficient Method For The Homologation Of Aldehydes To .Alpha.,.Beta.-Unsaturated Aldehydes 摘要: Doi:10.1021/jo00192A047
专利号:US-2005004225-A1 优先权日:2003-04-16 标题:Oxidoreductase inhibitors and methods of screening and using thereof 发明人:BALENDIRAN GANESARATNAM K 摘要:The present invention relates to 1) the design and synthesis of analogs to glutathione conjugates which bind to or interact with aldose reductase (AR) through unique conformations that are distinctly different from the substrates and inhibitors of AR which are members of sugar metabolism; 2) the screening of the analogs to identify those that interact with or inhibit or enhance the activity of AR; and 3) the use of AR ligands, AR inhibitors (AR antagonsits) or AR enhancer (AR agonists) in the detection of AR activity, the modulation of AR activity, and the treatment of conditions in a subject in need of modulating AR activity. Such conditions include but not limited to cardiovascular disease, diabetes, artheriosclerosis, cancer, neoplasm, obesity, cataract, retinopathy, keratopathy, nephropathy, neurosis, thrombosis, faulty union of corneal injury and neuropathy. Examples of the treatment include the use of fibrates as AR inhibitors to treat these conditions.
专利号:US-7838053-B2 优先权日:2004-03-11 标题:Barley for production of flavor-stable beverage 发明人:BREDDAM KLAUS; OLSEN OLE; SKADHAUGE BIRGITTE; LOK FINN; KNUDSEN SOEREN; BECH LENE MOELSKOV 权利人:CARLSBERG AS 摘要:According to the invention, there is provided null-LOX-1 barley and plant products produced thereof, such as malt manufactured by using barley kernels defective in synthesis of the fatty acid-converting enzyme lipoxygenase-1. Said enzyme accounts for the principal activity related to conversion of linoleic acid into 9-hydroperoxy octadecadienoic acid, a lipoxygenase pathway metabolite, which-through further enzymatic or spontaneous reactions-may lead to the appearance of trans-2-nonenal. The invention enables brewers to produce a beer devoid of detectable trans-2-nonenal-specific off flavors, even after prolonged storage of the beverage.
专利号:US-2025109161-A1 优先权日:2021-11-30 标 题 :Heme, compositions and method of synthesis thereof 发明人:LEONG TAI WEI DAVID; ANG WEE HAN; LEONG LAI PENG; THAM JING RUI 权利人:NAT UNIV SINGAPORE 摘要:The present disclosure concerns heme and methods of synthesis thereof. The present disclosure also concerns to compositions and products thereof. The heme composition comprises heme at about 0.05% w/w to about 1% w/w relative to the heme composition and an antioxidant at about 0.25% w/w to about 5% w/w relative to the heme composition, wherein the heme is derived from protoporphyrin IX extracted from a plant, algal, bacterial and/or animal source.
专利号:US-9363959-B2 优先权日:2008-12-30 标 题 :Barley with reduced lipoxygenase activity and beverage prepared therefrom 发明人:SKADHAUGE BIRGITTE; LOK FINN; BREDDAM KLAUS; OLSEN OLE; BECH LETTE MØLSKOV; KNUDSEN SØREN 权利人:SKADHAUGE BIRGITTE; LOK FINN; BREDDAM KLAUS; OLSEN OLE; BECH LETTE MØLSKOV; KNUDSEN SØREN; CARLSBERG BREWERIES AS; HEINEKEN SUPPLY CHAIN BV 摘要:According to the invention, there is provided barley with total loss of functional lipoxygenase (LOX)-1 and LOX-2 enzymes, and plant products produced thereof, such as malt manufactured by using barley kernels defective in the synthesis of the fatty acid-dioxygenating enzymes LOX-1 and LOX-2. Said enzymes account for the principal activities related to dioxygenation of linoleic acid into 9- and 13-hydroperoxy octadecadienoic acid, respectively. 9-Hydroperoxy octadecadienoic acid represents a LOX pathway metabolite, which—through further enzymatic or spontaneous reactions—may lead to the appearance of trans-2-nonenal (T2N). The invention enables brewers to produce a beer having insignificant levels of stale, T2N-specific off-flavors, even after prolonged storage of the beverage.
专利号:CN-118460568-A 优先权日:2024-05-28 标题 :Cucumber lipoxygenase CsLOX09 gene and application thereof in regulating and controlling synthesis of fruit aldehyde and corresponding alcohol aroma
专利号:US-2024016143-A1 优先权日:2020-10-29 标题:Open cell hydrogel networks and methods for making and using the same 发明人:NIEDERHAUSER WILLIAM R; SAWYER CHARLES; SAWYER WALLACE G; SAWYER WILLIAM W 权利人:UNIV FLORIDA 摘要:In one aspect, the disclosure relates to open cell hydrogel networks, methods of making the same and baits formed from the same, methods of loading the same with attractant molecules and compositions, and methods of catching fish and/or other aquatic organisms using the same. The open cell hydrogel networks disclosed herein can be configured to have different properties based on the specific polymers used for synthesis as well as any initiators, catalysts, and/or crosslinkers, thus allowing the fabrication of suitable baits for a variety of target species. In some aspects, the open cell hydrogel networks can be used as a filter or drug delivery device.
[参考文献]: Adriana Bravo, Et Al. Formation Of Alpha-Dicarbonyl Compounds In Beer During Storage Of Pilsner. J Agric Food Chem. 2008 Jun 11;56(11):4134-44. [参考文献]: Dagmar Kock, Et Al. A Male Sex Pheromone In A Scorpionfly. J Chem Ecol. 2007 Jun;33(6):1249-56. [参考文献]: Fabien Vincent, Et Al. Mining Biologically-Active Molecules For Inhibitors Of Fatty Acid Amide Hydrolase (Faah): Identification Of Phenmedipham And Amperozide As Faah Inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6793-6. [参考文献]: Gabriela Nava, Et Al. Characterization Of Taenia Solium Cysticerci Microsomal Glutathione S-Transferase Activity. Parasitol Res. 2007 Oct;101(5):1373-81. [参考文献]: Giangiacomo Beretta, Et Al. Glycyl-Histidyl-Lysine (Ghk) Is A Quencher Of Alpha,Beta-4-Hydroxy-Trans-2-Nonenal: A Comparison With Carnosine. Insights Into The Mechanism Of Reaction By Electrospray Ionization Mass Spectrometry, 1H Nmr, And Computational Techniques. Chem Res Toxicol. 2007 Sep;20(9):1309-14.
合成参考文献
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