CAS: 2004-06-0; 6-Chloropurine Ribonucleoside

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专利信息

专利号:US-9102698-B2
优先权日:2007-03-14
标 题:Process for the synthesis of IB-MECA
发明人：BRUZINSKI PAUL; LIU XUEJUN; GIBB CAMERON; HERNANDEZ-ABAD PEDRO E
权利人:BRUZINSKI PAUL; LIU XUEJUN; GIBB CAMERON; HERNANDEZ-ABAD PEDRO E; CAN FITE BIOPHARMA LTD
摘要:The present disclosure provides a method for the synthesis of IB-MECA. More specifically, the present disclosure provides a simple and high yield method for Good Manufacturing Production (GMP) of IB-MECA. The method involves the reaction of 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine; reaction of the diol protected 6-halopurine with a nucleophile (e.g. methylamine); substitution of the halogen group with iodobenzylamine and removal of the diol protecting group.

专利号:EP-0155950-B1
优先权日:1983-09-02
标题 :Oligonucleotide polymeric support system
发明人：ARNOLD LYLE J JR
权利人:MOLECULAR BIOSYSTEMS INC
摘要:A versatile polymeric support system for the synthesis of oligonucleotides featuring a universal primer which allows chain elongation, in either the 3' or 5' direction, with any currently available DNA or RNA synthesis method, by a process which utilizes oxidatively cleaved primers to facilitate chain elongation and release. The support system is capable of withstanding mildly basic and acidic reaction conditions, while still permitting a convenient and quantitative release, either before or after removal of protecting groups from reactive groups, of synthesized oligonucleotides from a single polymeric support. Removal of the protecting groups before cleavage of the oligomer from the support permits the use of the immobilized oligomer as an affinity hybridization support for both isolation and detecting complementary polynucleic acids.

专利号:US-8026349-B2
优先权日:2004-08-20
标题 :Polynucleotide synthesis labeling chemistry
发明人：HARTSEL STEPHANIE A; KAISER ROBERT J; DELANEY MICHAEL O
权利人:DHARMACON INC
摘要:Methods and compositions for making nucleoside phosphoramidites and nucleic acids, including mono-, di-, and polynucleotides, comprising a linker covalently attached to a levulinyl moiety are provided. A levulinyl-protected linking moiety affords an orthogonal approach to modifying a polynucleotide during or after solid phase synthesis with a molecule of interest, for example, a conjugate or a dye.

专利号:US-5539097-A
优先权日:1983-09-02
标题 :Oligonucleotide polymeric support system
发明人：ARNOLD LYLE J JR
权利人:MOLECULAR BIOSYSTEMS INC
摘要:A versatile polymeric support system for the synthesis of oligonucleotides is provided featuring a universal primer which allows chain elongation, in either the 3' or 5' direction, with any currently available DNA or RNA synthesis method, by a process which utilizes oxidatively cleaved primers to facilitate chain elongation and release. The support system is capable of withstanding mildly basic and acidic reaction conditions, while still permitting a convenient and quantitative release, either before or after removal of protecting groups from reactive groups, of synthesized oligonucleotides from a single polymeric support. Removal of the protecting groups before cleavage of the oligomer from the support permits the use of the immobilized oligomer as an affinity hybridization support for both isolating and detecting complementary polynucleic acids.

专利号:US-5362866-A
优先权日:1983-09-02
标 题:Oligonucleotide polymeric support system with an oxidation cleavable link
发明人：ARNOLD LYLE J JR
权利人:MOLECULAR BIOSYSTEMS INC
摘要:A versatile polymeric support system for the synthesis of oligonucleotides is provided featuring a universal primer which allows chain elongation, in either the 3' or 5' direction, with any currently available DNA or RNA synthesis method, by a process which utilizes oxidatively cleaved primers to facilitate chain elongation and release. The support system is capable of withstanding mildly basic and acidic reaction conditions, while still permitting a convenient and quantitative release, either before or after removal of protecting groups from reactive groups, of synthesized oligonucleotides from a single polymeric support. Removal of the protecting groups before cleavage of the oligomer from the support permits the use of the immobilized oligomer as an affinity hybridization support for both isolating and detecting complementary polynucleic acids.

专利号:US-6645513-B2
优先权日:1998-10-26
标题 :Treatment of skin with adenosine or adenosine analog
发明人：DOBSON JR JAMES G; ETHIER MICHAEL F
权利人:UNIV MASSACHUSETTS
摘要:Methods for enhancing the condition of non-diseased skin by application of compositions containing adenosine or an adenosine analog are disclosed. Also disclosed are methods for increasing DNA synthesis or protein synthesis in dermal cells, and methods for increasing dermal cell size, by application of compositions containing adenosine.