CAS: 216393-55-4; Methyl 3,5-Difluorobenzoate

上下游产品

methanol 3,5-difluorobenzoic acid10H8F2°C10H8F2O 4-(4-methylpiperazin-1-yl)-6-(3,5-difluorophenyl)-1,3,5-triazin-2-amine dideutero(3,5-difluorophenyl)methanol

五氟苯甲酸甲酯置于fac-Tris(2-Phenylpyridinato-N,C2')Iridium(III),N,N-二异丙基乙胺体系中,用 氘代苯,乙腈 用作溶剂,以92 %的收率获得3,5--二氟苯甲酸甲酯
参考文献:分子雕刻:通过苯甲酸盐的光催化加氢脱氟加快获得各种氟化芳烃的多用途工具
标题:分子雕刻:通过苯甲酸盐的光催化加氢脱氟加快获得各种氟化芳烃的多用途工具
摘要:从高度氟化的苯甲酸酯开始,我们开发了氟化苯甲酸芳基酯的定向光催化加氢脱氟 (Hdf),并展示了它与其他 Hdf 策略的协同作用,以及 C-H 芳基化,脱羧偶联和脱羧质子化,以获得大多数氟化模式苯甲酸酯衍生物,并通过分子雕刻方法扩展苯衍生物.温和的反应条件和出色的区域选择性使该方法成为合成的理想选择.这种方法提供了从几种高度氟化的市售苯甲酸中获得 16 种具有不同氟化模式的苯甲酸酯衍生物的途径.我们为西格列汀,二氟尼柳和其他药学上重要的分子合成关键中间体或活性药物成分.重要的,我们提供了关于相对脱氟率和改变这些率的策略的重要见解.我们展示了 Hdf 和相关技术的协同使用,以快速提高这些简单的商用全氟芳烃的合成复杂性,从而形成复杂的部分氟化分子.
Doi:10.1021/acs.Joc.2C02332

专利信息

专利号:US-7132092-B2
优先权日:2002-02-08
标 题:Metallized mesoporous silicate and method of oxidation with the same
发明人：HAGIYA KOJI
权利人:SUMITOMO CHEMICAL CO
摘要:A metallized mesoporous silicate which is obtained by (i) reacting (a) either a metal peroxide obtained by the reaction of an aqueous hydrogen peroxide solution with at least one metal or metal compound selected from the group consisting of the following 1) to 4) 1) tungsten 2) molybdenum 3) vanadium 4) compounds comprising 4 a ) any of tungsten, molybdenum, and vanadium and 4 b ) at least one element selected from Groups 13 to 16 (excluding oxygen) or a solution of the metal peroxide with (b) a silicon compound in the presence of an alkylamine or a quaternary ammonium salt and separating the resultant silicate; and a process for producing the metallized mesoporous silicate. Also provided is a method of organic synthesis with the silicate.

专利号:US-7993494-B2
优先权日:2008-01-23
标题:Method for manufacturing triarylpyrazine derivative
发明人：INOUE HIDEKO; NOMURA HIROKO
权利人:SEMICONDUCTOR ENERGY LAB
摘要:A novel synthesis method of a triarylpyrazine derivative, in particular, a manufacturing method by which a triarylpyrazine derivative, in specific, a 2,3,5-triarylpyrazine derivative in which an aryl group at a 5-position includes a substituent having an electron-withdrawing property can be synthesized with high yield as compared to a conventional method is provided. By using a synthesis method in which a mixture including a 1-aryl-2-(methylsulfinyl)ethanone derivative, meso-1,2-diarylethylenediamine, and a dehydrogenation agent is irradiated with a microwave to be reacted, the above object is achieved.

专利号:US-2012178931-A1
优先权日:2009-08-31
标题 :Process for preparation of pyrimidinylacetonitrile derivatives and intermediates for synthesis thereof

专利号:EP-2474536-B1
优先权日:2009-08-31
标 题 :Process for preparation of pyrimidinylacetonitrile derivatives and intermediates for synthesis thereof
发明人：KAWAZOE KENTARO
权利人:IHARA CHEMICAL IND CO

专利号:EP-2474536-A1
优先权日:2009-08-31
标题 :Process for preparation of pyrimidinylacetonitrile derivatives and intermediates for synthesis thereof