CAS: 22929-52-8; Dihydrofuran-3(2H)-One

相似化合物

86087-23-2 86087-24-3 86087-23-2

上下游产品

CAS号453-20-3 3-羟基四氢呋喃 | CAS号29212-66-6 furan-3-ol | CAS号1708-29-8 2,5-二氢呋喃 | CAS号57595-23-0 4-氧代四氢呋喃-3-羧酸甲酯 | CAS号106183-61-3 Morpholine,4-(4... | CAS号106183-62-4 Morpholine,4-(2... | CAS号453-20-3 3-羟基四氢呋喃 | CAS号137344-86-6 3-乙炔基氧杂-3-醇

2,5-二氢呋喃置于一氧化二氮体系中,用 苯 用作溶剂,化学反应 12.0H,反应生成二氢-3(2H)-呋喃酮
参考文献:一氧化二氮将烯烃液相氧化为羰基化合物
标题:一氧化二氮将烯烃液相氧化为羰基化合物
摘要:在使用氧化亚氮(n 2 O)的液相非催化氧化中,对包括线性,环状,杂环烯烃及其衍生物在内的各种底物进行了测试.烯烃的结构和组成对反应选择性有重要影响.对于许多烯烃,N 2 O氧化为制备羰基化合物提供了一种选择方法.卡宾(或重氮甲烷)物质的生成是末端烯烃氧化的显着特征.
Doi:10.1002/adsc.200303155

专利信息

专利号:WO-9946268-A1
优先权日:1998-03-12
标题 :MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases)
发明人：ANDERSEN HENRIK SUNE; JONES TODD KEVIN; HOLSWORTH DANIEL DALE
权利人:NOVO NORDISK AS; ONTOGEN CORP
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-2002019412-A1
优先权日:1998-03-12
标题:Modulators of protein tyrosine phosphatases (ptpases)
发明人：ANDERSEN HENRIK SUNE; JONES TODD KEVIN; HOLSWORTH DANIEL DALE
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-5567830-A
优先权日:1994-02-14
标题 :Process for synthesis of acetylenic carbinols
发明人：UPASANI RAVINDRA B
权利人:COCENSYS INC
摘要:A method for the preparation of an acetylenic alcohol by reaction of 1,2-dibromoethylene with an alkyl, aryl an heteroaryl lithium in an inert solvent, followed by reaction with a carbonyl-containing compound to give an acetylenic alcohol is disclosed.

专利号:US-2024239799-A1
优先权日:2021-04-02
标 题:(s)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'h,6'h-spiro[piperidine-4,5'-pyrrolo [1,2-b]pyrazol]-4'-amine derivatives and similar compounds as shp2 inhibitors for the treatment of e.g. cancer
发明人：DI FABIO ROMANO; MONTALBETTI CHRISTIAN; PETROCCHI ALESSIA; GRILLO ALESSANDRO; RANDAZZO PIETRO; ROSSETTI ILARIA; CIAMMAICHELLA ALINA
权利人:C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING; IRBM S P A
摘要:The present invention relates to compounds of formula (I). The compounds of the formula (I) are e.g. (S)-1-(5-((pyridin-3-yl)thio) pyrazin-2-yl)-41H,6′H-spiro[piperidine-4,5′-pyrrolo[1,2-b]pyrazol]-41-amine derivatives and similar compounds. The present invention also relates to the compounds of formula (I) for use as Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitors in methods of treatment of e.g. cancer, cardiovascular diseases, immunological disorders, autoimmune disorders, fibrosis, ocular disorders, systemic lupus erythematosus, diabetes, neutropenia, and combinations thereof. The present invention also relates to pharmaceutical compositions containing said compounds and to their methods of synthesis.

专利号:US-2010317848-A1
优先权日:2006-12-31
标题:Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments

专利号:US-2680743-A
优先权日:1951-02-06
标 题 :Synthesis of pyridoxine
发明人：STEVENS PHILIP G
权利人:GEN ANILINE & FILM CORP